ES8206180A1 - Un metodo para producir una composicion farmaceutica solida de un medicamento en microdosis. - Google Patents

Un metodo para producir una composicion farmaceutica solida de un medicamento en microdosis.

Info

Publication number
ES8206180A1
ES8206180A1 ES501122A ES501122A ES8206180A1 ES 8206180 A1 ES8206180 A1 ES 8206180A1 ES 501122 A ES501122 A ES 501122A ES 501122 A ES501122 A ES 501122A ES 8206180 A1 ES8206180 A1 ES 8206180A1
Authority
ES
Spain
Prior art keywords
microdose
solid
drug preparation
drug
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES501122A
Other languages
English (en)
Other versions
ES501122A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES8206180A1 publication Critical patent/ES8206180A1/es
Publication of ES501122A0 publication Critical patent/ES501122A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

METODO PARA PRODUCIR UNA COMPOSICION FARMACEUTICA SOLEDA DE UN MEDICAMENTO EN MICRODOSIS RECUBIERTO POR UNA CERA. SE DISPERSA UN MEDICAMENTO EN MICRODOSIS TAL COMO FUMARATO DE FORMOTEROL O B-METILDIGOXINA, DIRECTAMENTE EN UNA CERA FUNDIDA, TAL COMO UN ACEITE HIDROGENADO, Y SE ENFRIA LA DISPERSION BAJO AGITACION. LA CERA PUEDE ESTAR DISUELTA EN UN DISOLVENTE Y POSTERIORMENTE SE SEPARA DICHO DISOLVENTE. LA COMPOSICION ANTERIOR SE SOMETE A UNA GRANULACION O FORMACION EN POLVO MEDIANTE CONGELACION POR PULVERIZACION, SECADO A VACIO O SECADO POR PULVERIZACION, Y POSTERIORMENTE SE LE AÑADE UN EXCIPIENTE. POR ULTIMO SE FORMULA LA COMPOSICION RESULTANTE EN UNA COMPOSICION SOLIDA.
ES501122A 1980-04-07 1981-04-06 Un metodo para producir una composicion farmaceutica solida de un medicamento en microdosis. Granted ES501122A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4600280A JPS56140915A (en) 1980-04-07 1980-04-07 Pharmaceutical preparation for solid drug

Publications (2)

Publication Number Publication Date
ES8206180A1 true ES8206180A1 (es) 1982-06-01
ES501122A0 ES501122A0 (es) 1982-06-01

Family

ID=12734865

Family Applications (1)

Application Number Title Priority Date Filing Date
ES501122A Granted ES501122A0 (es) 1980-04-07 1981-04-06 Un metodo para producir una composicion farmaceutica solida de un medicamento en microdosis.

Country Status (5)

Country Link
US (1) US4380534A (es)
EP (1) EP0037740B1 (es)
JP (1) JPS56140915A (es)
DE (1) DE3172956D1 (es)
ES (1) ES501122A0 (es)

Families Citing this family (40)

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DK62184D0 (da) * 1984-02-10 1984-02-10 Benzon As Alfred Diffusionsovertrukket polydepotpraeparat
US4804548A (en) * 1984-10-05 1989-02-14 Warner-Lambert Company Novel sweetener delivery systems
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US4828857A (en) * 1984-10-05 1989-05-09 Warner-Lambert Company Novel sweetener delivery systems
SE8405611D0 (sv) * 1984-11-09 1984-11-09 Astra Laekemedel Ab Process for stabilization of bacampicillin hydrochloride
GB8501015D0 (en) * 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
PH25150A (en) * 1986-06-05 1991-03-13 Ciba Geigy Ag Novel pharmaceutical preparation for topical application
JPS63151353A (ja) * 1986-12-15 1988-06-23 Oogawara Kakoki Kk ワツクスコ−テイングマイクロカプセルの製造方法
US4937081A (en) * 1988-01-14 1990-06-26 Daicel Chemical Industries Ltd. Process for producing porous, spherical particles
US5372823A (en) * 1989-03-16 1994-12-13 Bristol-Myers Squibb Company Direct compression cholestyramine tablet and solvent-free coating thereof
US4956182A (en) * 1989-03-16 1990-09-11 Bristol-Myers Company Direct compression cholestyramine tablet and solvent-free coating therefor
ES2042292T3 (es) * 1989-03-17 1993-12-01 Pitman-Moore, Inc. Dispositivo de administracion de proteinas macromoleculares por liberacion controlada.
US5213810A (en) * 1990-03-30 1993-05-25 American Cyanamid Company Stable compositions for parenteral administration and method of making same
IE65045B1 (en) * 1990-04-28 1995-10-04 Takeda Chemical Industries Ltd Granulated preparations and method of producing the same
IE61651B1 (en) * 1990-07-04 1994-11-16 Zambon Spa Programmed release oral solid pharmaceutical dosage form
US5714167A (en) * 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5434304A (en) * 1990-09-26 1995-07-18 Aktiebolaget Astra Process for preparing formoterol and related compounds
AU650953B2 (en) * 1991-03-21 1994-07-07 Novartis Ag Inhaler
US6866839B2 (en) * 1991-04-05 2005-03-15 Sepracor Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US5795564A (en) * 1991-04-05 1998-08-18 Sepracor, Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US6299863B1 (en) 1992-04-03 2001-10-09 Sepracor Inc. Aerosol formulations containing micronized optically pure (R,R) formoterol for bronchodilating therapy
US5135954A (en) * 1991-05-24 1992-08-04 The Regents Of The University Of California Use of formoterol for treatment of tissue injury
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
US5690959A (en) * 1993-05-29 1997-11-25 Smithkline Beecham Corporation Pharmaceutical thermal infusion process
IL109770A0 (en) * 1993-05-29 1994-11-28 Smithkline Beecham Corp Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby
KR100354702B1 (ko) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5458888A (en) * 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
IL113816A (en) † 1994-06-08 1998-12-06 Akzo Nobel Nv Pharmaceutical preparations containing desogestral, their preparation and use
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5827537A (en) * 1995-05-04 1998-10-27 Smithkline Beecham Corporation Pharmaceutical thermal infusion process
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
FR2854802B1 (fr) * 2003-05-12 2005-06-24 Galderma Res & Dev Procede de preparation d'une formulation contenant un principe actif microdose
KR20100117603A (ko) * 2008-02-13 2010-11-03 바이엘 쉐링 파마 악티엔게젤샤프트 안정화 효과를 갖는 약물 전달 시스템
WO2009101021A2 (en) * 2008-02-13 2009-08-20 Bayer Schering Pharma Aktiengesellschaft Estradiol-containing drug delivery system
UY32836A (es) * 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
WO2012120365A1 (en) 2011-03-07 2012-09-13 Aurobindo Pharma Limited Stable pharmaceutical composition comprising ethinyl estradiol
FR3017775A1 (fr) * 2014-02-21 2015-08-28 Denis Et Fils Sas Cire a greffer pulverulente.

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2698822A (en) * 1951-04-28 1955-01-04 Fougera & Co Inc E Cardiac glycoside buccal composition
US2805977A (en) * 1955-01-04 1957-09-10 Smith Kline French Lab Sustained release pharmaceutical preparation
US2902407A (en) * 1955-06-14 1959-09-01 Commercial Solvents Corp Wax-coated penicillin product
US2875130A (en) * 1956-11-20 1959-02-24 Smith Kline French Lab Method of preparing sustained release particles and the product of the method
DE1078283B (de) * 1958-06-12 1960-03-24 Bayer Ag Verfahren zur Umhuellung oder Einbettung von pharmazeutischen Wirkstoffen
DE1417326A1 (de) * 1958-08-08 1968-10-24 Bayer Ag Verfahren zur Herstellung von oral anzuwendenden Arzneimittelzubereitungen mit protrahierter Wirkung
DE1080265B (de) * 1958-09-30 1960-04-21 Bayer Ag Verfahren zur Herstellung von oral anzuwendenden Arzneimittel-zubereitungen mit protrahierter Wirkung aus Wirkstoffen und Schutzstoffen
US3037911A (en) * 1959-09-04 1962-06-05 Merck & Co Inc Chewable, palatable, vitamin b preparations
US3035985A (en) * 1959-09-30 1962-05-22 Merck & Co Inc Chewable fatty coating of iron particles
US3080292A (en) * 1960-07-12 1963-03-05 Hoffmann La Roche Stable pleasant-tasting vitamin b containing beadlets
US3108046A (en) * 1960-11-25 1963-10-22 Smith Kline French Lab Method of preparing high dosage sustained release tablet and product of this method
US3078216A (en) * 1961-04-11 1963-02-19 American Cyanamid Co Prolonged release oral pharmaceutical preparations
US3279998A (en) * 1962-06-22 1966-10-18 Smith Kline French Lab Method of preparing sustained release tablets
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
US3803310A (en) * 1969-06-10 1974-04-09 Boehringer Sohn Ingelheim Cardiac-active pharmaceutical compositions containing a cardenolide glycoside
US3538215A (en) * 1969-06-13 1970-11-03 Allied Chem Stabilized antibiotic in liquid ruminant feed supplement
US3856699A (en) * 1969-08-08 1974-12-24 Fuji Photo Film Co Ltd Process for producing capsules having walls of a waxy material
US3655864A (en) * 1970-09-21 1972-04-11 Smith Kline French Lab Glyceryl tristerate and higher fatty acid mixture for improving digestive absorption
GB1415256A (en) * 1972-02-05 1975-11-26 Yamanouchi Pharma Co Ltd Alpha-aminomethylbenzyl alcohol derivatives
US3780170A (en) * 1972-07-03 1973-12-18 Warner Lambert Co Tasteless methenamine mandelate
GB1413186A (en) * 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US4151273A (en) * 1974-10-31 1979-04-24 The Regents Of The University Of California Increasing the absorption rate of insoluble drugs
JPS5231981A (en) * 1975-08-18 1977-03-10 Takeda Chem Ind Ltd Microcapsule preparation method
JPS52120976A (en) * 1976-04-06 1977-10-11 Fuji Photo Film Co Ltd Manufacture of capsule having wall of waxy material
US4202888A (en) * 1976-07-12 1980-05-13 Kali-Chemie Pharma Gmbh. Readily enterally absorbable pharmaceutical compositions of cardiac glycosides and preparation thereof
US4147768A (en) * 1976-09-13 1979-04-03 Interx Research Corporation Enteric coated digoxin and therapeutic use thereof
US4230702A (en) * 1978-01-09 1980-10-28 Kali-Chemie Pharma Gmbh Readily enterally absorbable pharmaceutical compositions of per se poorly enterally absorbable pharmacologically active agents
GB2016922B (en) * 1978-02-17 1982-08-18 Delandale Lab Ltd Sustained release lithium carbonate tables

Also Published As

Publication number Publication date
US4380534A (en) 1983-04-19
JPS56140915A (en) 1981-11-04
DE3172956D1 (en) 1986-01-02
ES501122A0 (es) 1982-06-01
EP0037740B1 (en) 1985-11-21
EP0037740A2 (en) 1981-10-14
EP0037740A3 (en) 1982-05-12

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