ES8207142A1 - Procedimiento para preparar derivados de piridoxina - Google Patents
Procedimiento para preparar derivados de piridoxinaInfo
- Publication number
- ES8207142A1 ES8207142A1 ES506375A ES506375A ES8207142A1 ES 8207142 A1 ES8207142 A1 ES 8207142A1 ES 506375 A ES506375 A ES 506375A ES 506375 A ES506375 A ES 506375A ES 8207142 A1 ES8207142 A1 ES 8207142A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pyridoxine
- piridoxine
- derivatives
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- CZFIJMPIIQHVJD-UHFFFAOYSA-N (2,2,8-trimethyl-4h-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol Chemical compound C1OC(C)(C)OC2=C1C(CO)=CN=C2C CZFIJMPIIQHVJD-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 235000008160 pyridoxine Nutrition 0.000 abstract 1
- 239000011677 pyridoxine Substances 0.000 abstract 1
- 150000003227 pyridoxines Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
- C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDOXINA DE FORMULA (I), EN LA QUE R1 ES EL RESTO DE UNO DE VARIOS ACIDOS. CONSISTE EN LA REACCION DE IOSPROPOLINEN-PIRIDOXINA CON EL HALURO DEL ACIDO, EN PRESENCIA DE UNA BASE COMO ACEPTOR DE ACIDO, TAL COMO UNA AMINA TERCIARIA, SEGUIDA DE LA HIDROLISIS DEL ESTER FORMADO, MEDIANTE CALENTAMIENTO A REFLUJO DE ESTE HIDROALCOHOLICO CONSTITUIDO POR AGUA Y UN ALCOHOL ALIFATICO INFERIOR EN LA RELACION DE 1:2 A 1:5. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTIINFLAMATORIAS, ANTIFLOGISTICAS Y ANALGESICAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT25473/80A IT1133963B (it) | 1980-10-21 | 1980-10-21 | Derivati piridossinici ad attivita' terapeutica,procedimento per la loro preparazione e relative composizioni farmaceutiche |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES506375A0 ES506375A0 (es) | 1982-09-01 |
| ES8207142A1 true ES8207142A1 (es) | 1982-09-01 |
Family
ID=11216796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES506375A Expired ES8207142A1 (es) | 1980-10-21 | 1981-10-20 | Procedimiento para preparar derivados de piridoxina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4412996A (es) |
| EP (1) | EP0050385B1 (es) |
| JP (1) | JPS5795962A (es) |
| AR (1) | AR230747A1 (es) |
| AT (1) | ATE17850T1 (es) |
| AU (1) | AU551422B2 (es) |
| BE (1) | BE890798A (es) |
| CA (1) | CA1190922A (es) |
| DE (1) | DE3173724D1 (es) |
| DK (1) | DK462181A (es) |
| ES (1) | ES8207142A1 (es) |
| FR (1) | FR2492375B1 (es) |
| IT (1) | IT1133963B (es) |
| MX (1) | MX154715A (es) |
| NO (1) | NO159855C (es) |
| PT (1) | PT73844B (es) |
| YU (1) | YU42439B (es) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3717636A (en) * | 1970-01-21 | 1973-02-20 | A Esanu | Salts of pyridoxine mono-esters |
| ES411535A1 (es) * | 1973-02-12 | 1976-01-01 | Farmabion S A | Un procedimiento para la preparacion de esteres del 1-(p- cloro-benzoil)-5-metoxi-2 metilindol-3-acetico, con feno- les. |
| SE428560B (sv) * | 1974-07-22 | 1983-07-11 | Merck & Co Inc | Forfarande for framstellning av 5-(2,4-difluorofenyl)salicylsyra. |
| JPS52156862A (en) * | 1976-06-22 | 1977-12-27 | Hisamitsu Pharmaceut Co Inc | Novel indoleacetic acid ester derivatives |
| CH601228A5 (en) * | 1977-06-17 | 1978-06-30 | Hisamitsu Pharmaceutical Co | Antiinflammatory indomethacin esters active topically and orally |
| IT1097601B (it) * | 1978-07-31 | 1985-08-31 | Crinos Industria Farmaco | Derivati della piridosina ad attivita' farmacologica |
| US4233304A (en) * | 1978-07-31 | 1980-11-11 | Crinos Industria Farmacobiologica S.P.A. | Pyridoxine derivatives |
-
1980
- 1980-10-21 IT IT25473/80A patent/IT1133963B/it active
-
1981
- 1981-10-08 EP EP81201119A patent/EP0050385B1/en not_active Expired
- 1981-10-08 AT AT81201119T patent/ATE17850T1/de not_active IP Right Cessation
- 1981-10-08 DE DE8181201119T patent/DE3173724D1/de not_active Expired
- 1981-10-16 MX MX189679A patent/MX154715A/es unknown
- 1981-10-19 PT PT73844A patent/PT73844B/pt not_active IP Right Cessation
- 1981-10-19 AR AR287139A patent/AR230747A1/es active
- 1981-10-19 FR FR8119578A patent/FR2492375B1/fr not_active Expired
- 1981-10-20 CA CA000388324A patent/CA1190922A/en not_active Expired
- 1981-10-20 BE BE0/206296A patent/BE890798A/fr not_active IP Right Cessation
- 1981-10-20 NO NO813537A patent/NO159855C/no unknown
- 1981-10-20 ES ES506375A patent/ES8207142A1/es not_active Expired
- 1981-10-20 AU AU76622/81A patent/AU551422B2/en not_active Ceased
- 1981-10-20 DK DK462181A patent/DK462181A/da not_active Application Discontinuation
- 1981-10-20 JP JP56166500A patent/JPS5795962A/ja active Granted
- 1981-10-20 US US06/313,311 patent/US4412996A/en not_active Expired - Lifetime
- 1981-10-21 YU YU2519/81A patent/YU42439B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4412996A (en) | 1983-11-01 |
| JPS5795962A (en) | 1982-06-15 |
| AU551422B2 (en) | 1986-05-01 |
| YU251981A (en) | 1984-02-29 |
| NO159855B (no) | 1988-11-07 |
| AR230747A1 (es) | 1984-06-29 |
| IT1133963B (it) | 1986-07-24 |
| IT8025473A0 (it) | 1980-10-21 |
| CA1190922A (en) | 1985-07-23 |
| EP0050385A1 (en) | 1982-04-28 |
| FR2492375A1 (fr) | 1982-04-23 |
| ES506375A0 (es) | 1982-09-01 |
| MX154715A (es) | 1987-12-03 |
| EP0050385B1 (en) | 1986-02-05 |
| ATE17850T1 (de) | 1986-02-15 |
| BE890798A (fr) | 1982-02-15 |
| FR2492375B1 (fr) | 1986-10-10 |
| JPH0343268B2 (es) | 1991-07-01 |
| AU7662281A (en) | 1982-09-09 |
| YU42439B (en) | 1988-08-31 |
| DK462181A (da) | 1982-04-22 |
| PT73844A (en) | 1981-11-01 |
| DE3173724D1 (en) | 1986-03-20 |
| PT73844B (en) | 1983-01-25 |
| NO813537L (no) | 1982-04-22 |
| NO159855C (no) | 1989-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990503 |