ES8204419A1 - Procedimiento de preparar prostaglandina cristalina y esta- ble - Google Patents
Procedimiento de preparar prostaglandina cristalina y esta- bleInfo
- Publication number
- ES8204419A1 ES8204419A1 ES504993A ES504993A ES8204419A1 ES 8204419 A1 ES8204419 A1 ES 8204419A1 ES 504993 A ES504993 A ES 504993A ES 504993 A ES504993 A ES 504993A ES 8204419 A1 ES8204419 A1 ES 8204419A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- solution
- prostaglandin
- water
- pgf2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PXGPLTODNUVGFL-BRIYLRKRSA-N (E,Z)-(1R,2R,3R,5S)-7-(3,5-Dihydroxy-2-((3S)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic acid Chemical compound CCCCC[C@H](O)C=C[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC=CCCCC(O)=O PXGPLTODNUVGFL-BRIYLRKRSA-N 0.000 title abstract 11
- PXGPLTODNUVGFL-UHFFFAOYSA-N prostaglandin F2alpha Natural products CCCCCC(O)C=CC1C(O)CC(O)C1CC=CCCCC(O)=O PXGPLTODNUVGFL-UHFFFAOYSA-N 0.000 title abstract 5
- 238000000746 purification Methods 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000008043 acidic salts Chemical class 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 230000008018 melting Effects 0.000 abstract 2
- 238000002844 melting Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 150000007519 polyprotic acids Polymers 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU192080A HU180161B (en) | 1980-08-01 | 1980-08-01 | Process for preparing crystalline,stable prostaglandin f down 2alpha with a melting point over 35 c from contaminated prostaglandin f down 2alpha containing 50-98% prostaglandin f down 2alpha |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES504993A0 ES504993A0 (es) | 1982-05-16 |
| ES8204419A1 true ES8204419A1 (es) | 1982-05-16 |
Family
ID=10956846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES504993A Expired ES8204419A1 (es) | 1980-08-01 | 1981-07-31 | Procedimiento de preparar prostaglandina cristalina y esta- ble |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5764664A (ru) |
| AT (1) | AT378767B (ru) |
| CH (1) | CH648826A5 (ru) |
| DE (1) | DE3129637A1 (ru) |
| DK (1) | DK156829C (ru) |
| ES (1) | ES8204419A1 (ru) |
| FR (1) | FR2487828A1 (ru) |
| GR (1) | GR74277B (ru) |
| HU (1) | HU180161B (ru) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS49100059A (ru) * | 1973-02-03 | 1974-09-20 | ||
| US3941886A (en) * | 1973-09-21 | 1976-03-02 | Alza Corporation | Pharmaceutical compositions containing crystalline racemic 9α, 11α, 15(S)-trihydroxy-5-cis, 13-trans-prostadienoic acid |
-
1980
- 1980-08-01 HU HU192080A patent/HU180161B/hu unknown
-
1981
- 1981-07-28 DE DE19813129637 patent/DE3129637A1/de active Granted
- 1981-07-30 FR FR8114832A patent/FR2487828A1/fr active Granted
- 1981-07-31 AT AT337681A patent/AT378767B/de not_active IP Right Cessation
- 1981-07-31 GR GR65683A patent/GR74277B/el unknown
- 1981-07-31 ES ES504993A patent/ES8204419A1/es not_active Expired
- 1981-07-31 CH CH497381A patent/CH648826A5/de not_active IP Right Cessation
- 1981-07-31 DK DK344081A patent/DK156829C/da not_active IP Right Cessation
- 1981-07-31 JP JP11943681A patent/JPS5764664A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AT378767B (de) | 1985-09-25 |
| DK156829C (da) | 1990-02-19 |
| HU180161B (en) | 1983-02-28 |
| GR74277B (ru) | 1984-06-21 |
| ES504993A0 (es) | 1982-05-16 |
| JPS5764664A (en) | 1982-04-19 |
| ATA337681A (de) | 1985-02-15 |
| DE3129637C2 (ru) | 1991-05-29 |
| DK344081A (da) | 1982-02-02 |
| CH648826A5 (de) | 1985-04-15 |
| FR2487828B1 (ru) | 1984-01-06 |
| DK156829B (da) | 1989-10-09 |
| DE3129637A1 (de) | 1982-05-13 |
| FR2487828A1 (fr) | 1982-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20010910 |