ES8200082A1 - Procedimiento para esterilizar un agente de contraste de ra-yos x de m-carboxamido-o-yodo-n-(b-hidroxialcohil)-anilina. - Google Patents

Procedimiento para esterilizar un agente de contraste de ra-yos x de m-carboxamido-o-yodo-n-(b-hidroxialcohil)-anilina.

Info

Publication number
ES8200082A1
ES8200082A1 ES79482131A ES482131A ES8200082A1 ES 8200082 A1 ES8200082 A1 ES 8200082A1 ES 79482131 A ES79482131 A ES 79482131A ES 482131 A ES482131 A ES 482131A ES 8200082 A1 ES8200082 A1 ES 8200082A1
Authority
ES
Spain
Prior art keywords
ray contrast
contrast agent
physiologically acceptable
solutions
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES79482131A
Other languages
English (en)
Other versions
ES482131A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nyegaard and Co AS
Original Assignee
Nyegaard and Co AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard and Co AS filed Critical Nyegaard and Co AS
Publication of ES8200082A1 publication Critical patent/ES8200082A1/es
Publication of ES482131A0 publication Critical patent/ES482131A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/90—In vivo diagnostic or in vivo test agent which contains an additional ingredient to reduce the toxicity or side effects of the active ingredient

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA ESTERILIZAR UN AGENTE DE CONSTRASTE DE RAYOS X DE M-CARBOXAMIDO-O-YODO-N-(B-HIROXIALCOHIL)-ANILINA. CONSISTE EN CALENTAR UNA SOLUCION DEL AGENTE DE CONTRASTE DE M-CARBOXAMIDO-O-YODO-N-(B-HIDROXIALCOHIL)-ANILINA, A UNA TEMPERATURA DE 100 A 160 C BAJO PRESION EN PRESENCIA DE UN SISTEMA TAMPON CUYO PH DISMINUYE AL AUMENTAR LA TEMPERATURA. DICHA SOLUCION TIENE INICIALMENTE UN PH DE 6,8 A 8,0. LA CONCENTRACION DEL AGENTE DE CONTRASTE DE RAYOS X EN LA SOLUCION A TRATAR EN AUTOCLAVE ES DE 100 A 450 MG. POR MIL. EL PKA DEL SISTEMA TAMPON ES MENOR O IGUAL A 9,5. LA CONCENTRACION DEL TAMPON EN LA SOLUCION NO ES MAYOR DE 50 MOLA
ES482131A 1978-07-04 1979-07-03 Procedimiento para esterilizar un agente de contraste de ra-yos x de m-carboxamido-o-yodo-n-(b-hidroxialcohil)-anilina. Granted ES482131A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7828764 1978-07-04
KR1019790002214A KR830001643B1 (ko) 1978-07-04 1979-07-03 X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법

Publications (2)

Publication Number Publication Date
ES8200082A1 true ES8200082A1 (es) 1980-12-16
ES482131A0 ES482131A0 (es) 1980-12-16

Family

ID=26268114

Family Applications (1)

Application Number Title Priority Date Filing Date
ES482131A Granted ES482131A0 (es) 1978-07-04 1979-07-03 Procedimiento para esterilizar un agente de contraste de ra-yos x de m-carboxamido-o-yodo-n-(b-hidroxialcohil)-anilina.

Country Status (22)

Country Link
US (2) US4278654A (es)
JP (1) JPS5531068A (es)
KR (1) KR830001643B1 (es)
AR (1) AR222337A1 (es)
AT (1) AT371998B (es)
AU (1) AU523295B2 (es)
BE (1) BE877443A (es)
CA (1) CA1132901A (es)
CH (1) CH649469A5 (es)
DE (1) DE2926850C2 (es)
DK (1) DK155714C (es)
ES (1) ES482131A0 (es)
FI (1) FI75492C (es)
FR (1) FR2435253A1 (es)
HK (1) HK59984A (es)
IT (1) IT1193761B (es)
NL (1) NL183121C (es)
NZ (1) NZ190907A (es)
PT (1) PT69869A (es)
SE (1) SE445971B (es)
SG (1) SG5784G (es)
ZA (1) ZA793313B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
DE3689330T2 (de) * 1985-08-09 1994-05-19 Cook Imaging Corp Nichtionische polyolkontrastmittel aus ionischen kontrastmitteln.
US4718463A (en) * 1985-12-20 1988-01-12 Mallinckrodt, Inc. Method of producing prefilled sterile plastic syringes
US5284645A (en) * 1987-08-05 1994-02-08 Alliance Pharmaceutical Corp. Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems
US5847009A (en) * 1986-01-14 1998-12-08 Alliance Pharmaceutical Corp. Prophylaxis in the parenteral administration of particulate dispersions in fluorocarbon emulsions
US4863714A (en) * 1987-02-05 1989-09-05 Cook Imaging Corporation Sterilization of compositions of limited stability
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5191120A (en) * 1989-12-13 1993-03-02 Mallinckrodt Medical, Inc. Process for preparing nonionic X-ray contrast agents
DE4111939A1 (de) * 1991-04-12 1992-10-22 Fresenius Ag Parenteral verabreichbare, hitzesterilisierbare o/w-emulsion eines roentgenkontrastmittels
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
DE4316722A1 (de) * 1993-05-19 1994-11-24 Fresenius Ag Parenteral verabreichbare, unter Hitzesterilisationsbedingungen stabile O/W-Emulsion eines Röntgenkontrastmittels
CN1209751A (zh) 1996-01-25 1999-03-03 舍林股份公司 血管内使用的改进的浓缩注射液和输注液
DE19648650C2 (de) * 1996-01-29 1998-07-02 Schering Ag Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
US7250153B2 (en) * 2002-12-12 2007-07-31 Biophysica Research, Inc. Contrast media formulations having improved biological tolerance
KR101915821B1 (ko) * 2010-03-23 2018-11-06 지이 헬스케어 에이에스 안정화된 ｘ―선 진단용 조성물의 제조
WO2013180777A1 (en) * 2012-05-30 2013-12-05 Verrow Pharmaceuticals, Inc. Stabilized formulations containing iodinated contrast agents and cyclodextrins

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3190E (fr) * 1904-09-30 Jules Cesar Napoleon Fouilloy Collier d'attache pour protecteur antidérapant de pneumatiques
NL127881C (es) * 1963-03-25
GB1069437A (en) * 1963-10-23 1967-05-17 Nyegaard & Co As Injectable x-ray contrast media
US3733397A (en) * 1966-12-02 1973-05-15 Pharmacia Ab Method for the x-ray visualization of body cavities and a preparation for carrying out the method
SE315975B (es) * 1967-12-28 1969-10-13 Pharmacia Ab
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
GB1321591A (en) * 1969-06-27 1973-06-27 Nyegaard & Co As Non-ionic iodinated x-ray contrast agents
CH583562A5 (es) * 1973-07-17 1977-01-14 Bracco Ind Chimica Spa
GB1495679A (en) * 1974-06-17 1977-12-21 Mallinckrodt Inc Substituted isophthalamic acids
US3953497A (en) * 1974-07-29 1976-04-27 Mallinckrodt, Inc. 2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts, acyl halides and esters thereof
GB1514920A (en) * 1974-10-09 1978-06-21 Reckitt & Colmann Prod Ltd Dispensing container for medicinal foams
FI760068A (es) * 1975-02-03 1976-08-04 Schering Ag
DE2505218A1 (de) * 1975-02-05 1976-08-19 Schering Ag Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same

Also Published As

Publication number Publication date
US4396597A (en) 1983-08-02
CA1132901A (en) 1982-10-05
US4278654A (en) 1981-07-14
SE7905830L (sv) 1980-01-05
ZA793313B (en) 1980-08-27
HK59984A (en) 1984-08-10
AR222337A1 (es) 1981-05-15
FI75492B (fi) 1988-03-31
DK155714C (da) 1989-10-30
AU4861579A (en) 1980-02-07
DK155714B (da) 1989-05-08
FI792101A (fi) 1980-01-05
AT371998B (de) 1983-08-25
NZ190907A (en) 1981-10-19
SE445971B (sv) 1986-08-04
JPS5531068A (en) 1980-03-05
FR2435253B1 (es) 1984-03-16
IT1193761B (it) 1988-08-24
DE2926850C2 (de) 1985-01-24
DK280979A (da) 1980-01-05
DE2926850A1 (de) 1980-03-06
FR2435253A1 (fr) 1980-04-04
BE877443A (fr) 1980-01-03
KR830001643B1 (ko) 1983-08-22
AU523295B2 (en) 1982-07-22
IT7949618A0 (it) 1979-07-03
ATA464479A (de) 1983-01-15
SG5784G (en) 1985-02-01
NL183121C (nl) 1988-08-01
NL7905166A (nl) 1980-01-08
FI75492C (fi) 1988-07-11
JPS6210209B2 (es) 1987-03-05
CH649469A5 (de) 1985-05-31
NL183121B (nl) 1988-03-01
KR830000911A (ko) 1983-04-28
ES482131A0 (es) 1980-12-16
PT69869A (en) 1979-08-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20001218