DE2926850A1 - Verfahren zur herstellung einer sterilen injizierbaren physiologisch annehmbaren loesung eines roentgenkontrastmittels und loesungen des roentgenkontrastmittels und eines puffers - Google Patents

Verfahren zur herstellung einer sterilen injizierbaren physiologisch annehmbaren loesung eines roentgenkontrastmittels und loesungen des roentgenkontrastmittels und eines puffers

Info

Publication number
DE2926850A1
DE2926850A1 DE2926850A DE2926850A DE2926850A1 DE 2926850 A1 DE2926850 A1 DE 2926850A1 DE 2926850 A DE2926850 A DE 2926850A DE 2926850 A DE2926850 A DE 2926850A DE 2926850 A1 DE2926850 A1 DE 2926850A1
Authority
DE
Germany
Prior art keywords
ray contrast
buffer
solutions
producing
physiologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2926850A
Other languages
English (en)
Other versions
DE2926850C2 (de
Inventor
Fridtjov Bernhard Rakli
Michael James Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nyegaard & Co Oslo AS
Nyegaard and Co AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co Oslo AS, Nyegaard and Co AS filed Critical Nyegaard & Co Oslo AS
Publication of DE2926850A1 publication Critical patent/DE2926850A1/de
Application granted granted Critical
Publication of DE2926850C2 publication Critical patent/DE2926850C2/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/90—In vivo diagnostic or in vivo test agent which contains an additional ingredient to reduce the toxicity or side effects of the active ingredient

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DE2926850A 1978-07-04 1979-07-03 Verfahren zur Herstellung einer sterilen injizierbaren physiologisch annehmbaren Lösung eines nicht ionischen m-Carboxamido-o-jodo-N-(β-hydroxyalkyl)-anilin-Röntgenkontrastmittels und Lösungen des Röntgenkontrastmittels und eines Puffers Expired DE2926850C2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7828764 1978-07-04
KR1019790002214A KR830001643B1 (ko) 1978-07-04 1979-07-03 X-선 조영제의 생리적으로 허용되는 멸균 주사용 용액을 제조하는 방법

Publications (2)

Publication Number Publication Date
DE2926850A1 true DE2926850A1 (de) 1980-03-06
DE2926850C2 DE2926850C2 (de) 1985-01-24

Family

ID=26268114

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2926850A Expired DE2926850C2 (de) 1978-07-04 1979-07-03 Verfahren zur Herstellung einer sterilen injizierbaren physiologisch annehmbaren Lösung eines nicht ionischen m-Carboxamido-o-jodo-N-(β-hydroxyalkyl)-anilin-Röntgenkontrastmittels und Lösungen des Röntgenkontrastmittels und eines Puffers

Country Status (22)

Country Link
US (2) US4278654A (de)
JP (1) JPS5531068A (de)
KR (1) KR830001643B1 (de)
AR (1) AR222337A1 (de)
AT (1) AT371998B (de)
AU (1) AU523295B2 (de)
BE (1) BE877443A (de)
CA (1) CA1132901A (de)
CH (1) CH649469A5 (de)
DE (1) DE2926850C2 (de)
DK (1) DK155714C (de)
ES (1) ES482131A0 (de)
FI (1) FI75492C (de)
FR (1) FR2435253A1 (de)
HK (1) HK59984A (de)
IT (1) IT1193761B (de)
NL (1) NL183121C (de)
NZ (1) NZ190907A (de)
PT (1) PT69869A (de)
SE (1) SE445971B (de)
SG (1) SG5784G (de)
ZA (1) ZA793313B (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4316722A1 (de) * 1993-05-19 1994-11-24 Fresenius Ag Parenteral verabreichbare, unter Hitzesterilisationsbedingungen stabile O/W-Emulsion eines Röntgenkontrastmittels
DE19648650A1 (de) * 1996-01-29 1997-08-07 Schering Ag Puffersysteme zur Stabilisierung pharmazeutischer Zubereitungen

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
US5035877A (en) * 1985-08-09 1991-07-30 Cook Imaging Corporation Non-ionic contrast media from ionic contrast media
WO1987000757A1 (en) * 1985-08-09 1987-02-12 Cook Imaging, Inc. Non-ionic polyol contrast media from ionic contrast media
US4718463A (en) * 1985-12-20 1988-01-12 Mallinckrodt, Inc. Method of producing prefilled sterile plastic syringes
US5284645A (en) * 1987-08-05 1994-02-08 Alliance Pharmaceutical Corp. Fluorocarbon emulsions containing amino acid based anti-inflamatory agents and buffer systems
US5847009A (en) * 1986-01-14 1998-12-08 Alliance Pharmaceutical Corp. Prophylaxis in the parenteral administration of particulate dispersions in fluorocarbon emulsions
US4863714A (en) * 1987-02-05 1989-09-05 Cook Imaging Corporation Sterilization of compositions of limited stability
IL94718A (en) * 1989-07-05 1994-10-21 Schering Ag Non-ionic carboxamide contrast agent and method of preparation
US5698739A (en) * 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US5191120A (en) * 1989-12-13 1993-03-02 Mallinckrodt Medical, Inc. Process for preparing nonionic X-ray contrast agents
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
DE4111939A1 (de) * 1991-04-12 1992-10-22 Fresenius Ag Parenteral verabreichbare, hitzesterilisierbare o/w-emulsion eines roentgenkontrastmittels
US5169864A (en) * 1991-11-15 1992-12-08 Baxter International Inc. Unbuffered premixed ranitidine formulation
HUP9901355A3 (en) 1996-01-25 2000-06-28 Schering Ag For using amino acids and - compounds for additives of x-ray contrast matter solucions, and making drugs and diagnostics
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
US7250153B2 (en) * 2002-12-12 2007-07-31 Biophysica Research, Inc. Contrast media formulations having improved biological tolerance
CA2793277C (en) * 2010-03-23 2018-09-04 Ge Healthcare As Preparation of stabilised x-ray diagnostic composition
EP2854531A4 (de) * 2012-05-30 2016-03-23 Verrow Pharmaceuticals Inc Stabilisierte formulierungen mit iodhaltigen kontrastmitteln und cyclodextrinen

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3190E (fr) * 1904-09-30 Jules Cesar Napoleon Fouilloy Collier d'attache pour protecteur antidérapant de pneumatiques
NL127881C (de) * 1963-03-25
GB1069437A (en) * 1963-10-23 1967-05-17 Nyegaard & Co As Injectable x-ray contrast media
US3733397A (en) * 1966-12-02 1973-05-15 Pharmacia Ab Method for the x-ray visualization of body cavities and a preparation for carrying out the method
SE315975B (de) * 1967-12-28 1969-10-13 Pharmacia Ab
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
GB1321591A (en) * 1969-06-27 1973-06-27 Nyegaard & Co As Non-ionic iodinated x-ray contrast agents
CH583562A5 (de) * 1973-07-17 1977-01-14 Bracco Ind Chimica Spa
GB1495679A (en) * 1974-06-17 1977-12-21 Mallinckrodt Inc Substituted isophthalamic acids
US3953497A (en) * 1974-07-29 1976-04-27 Mallinckrodt, Inc. 2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts, acyl halides and esters thereof
GB1514920A (en) * 1974-10-09 1978-06-21 Reckitt & Colmann Prod Ltd Dispensing container for medicinal foams
FI760068A (de) * 1975-02-03 1976-08-04 Schering Ag
DE2505218A1 (de) * 1975-02-05 1976-08-19 Schering Ag Neue orale roentgenkontrastmittel und verfahren zu ihrer herstellung
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
US4256729A (en) * 1979-03-23 1981-03-17 Mallinckrodt, Inc. N,N'-Bis-(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-keto-L-gulonamido)isophthalamide and radiological compositions containing same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4316722A1 (de) * 1993-05-19 1994-11-24 Fresenius Ag Parenteral verabreichbare, unter Hitzesterilisationsbedingungen stabile O/W-Emulsion eines Röntgenkontrastmittels
DE19648650A1 (de) * 1996-01-29 1997-08-07 Schering Ag Puffersysteme zur Stabilisierung pharmazeutischer Zubereitungen
DE19648650C2 (de) * 1996-01-29 1998-07-02 Schering Ag Puffersysteme und deren Verwendung zur Stabilisierung pharmazeutischer Zubereitung

Also Published As

Publication number Publication date
IT7949618A0 (it) 1979-07-03
AU523295B2 (en) 1982-07-22
CA1132901A (en) 1982-10-05
HK59984A (en) 1984-08-10
IT1193761B (it) 1988-08-24
ES8200082A1 (es) 1980-12-16
SG5784G (en) 1985-02-01
NL183121C (nl) 1988-08-01
US4396597A (en) 1983-08-02
AU4861579A (en) 1980-02-07
DK155714C (da) 1989-10-30
DK280979A (da) 1980-01-05
DE2926850C2 (de) 1985-01-24
DK155714B (da) 1989-05-08
FR2435253B1 (de) 1984-03-16
FR2435253A1 (fr) 1980-04-04
FI792101A (fi) 1980-01-05
NL7905166A (nl) 1980-01-08
CH649469A5 (de) 1985-05-31
NL183121B (nl) 1988-03-01
SE7905830L (sv) 1980-01-05
ZA793313B (en) 1980-08-27
KR830000911A (ko) 1983-04-28
PT69869A (en) 1979-08-01
SE445971B (sv) 1986-08-04
KR830001643B1 (ko) 1983-08-22
NZ190907A (en) 1981-10-19
FI75492B (fi) 1988-03-31
US4278654A (en) 1981-07-14
AT371998B (de) 1983-08-25
ES482131A0 (es) 1980-12-16
JPS5531068A (en) 1980-03-05
FI75492C (fi) 1988-07-11
ATA464479A (de) 1983-01-15
AR222337A1 (es) 1981-05-15
JPS6210209B2 (de) 1987-03-05
BE877443A (fr) 1980-01-03

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Legal Events

Date Code Title Description
OD Request for examination
8128 New person/name/address of the agent

Representative=s name: ZUMSTEIN SEN., F., DR. ASSMANN, E., DIPL.-CHEM. DR

D2 Grant after examination
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: NYCOMED A/S, OSLO, NO

8328 Change in the person/name/address of the agent

Free format text: ZUMSTEIN, F., DIPL.-CHEM. DR.RER.NAT. ASSMANN, E., DIPL.-CHEM. DR.RER.NAT. KLINGSEISEN, F., DIPL.-ING., PAT.-ANWAELTE, 8000 MUENCHEN