ES8106901A1 - Procedimiento para la preparacion de nuevas carboxamidas vinilogas. - Google Patents

Procedimiento para la preparacion de nuevas carboxamidas vinilogas.

Info

Publication number
ES8106901A1
ES8106901A1 ES493852A ES493852A ES8106901A1 ES 8106901 A1 ES8106901 A1 ES 8106901A1 ES 493852 A ES493852 A ES 493852A ES 493852 A ES493852 A ES 493852A ES 8106901 A1 ES8106901 A1 ES 8106901A1
Authority
ES
Spain
Prior art keywords
carbon atoms
methyl
hydrogen
alkyls
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493852A
Other languages
English (en)
Other versions
ES493852A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES493852A0 publication Critical patent/ES493852A0/es
Publication of ES8106901A1 publication Critical patent/ES8106901A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pens And Brushes (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Furan Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE CARBOXAMIDAS VINILOGAS, DE FORMULA GENERAL (I), DONDE AR SIGNIFICA UN RADICAL FENILO O PIRIDINILO; R SIGNIFICA HIDROGENO, CLORO O EL GRUPO METILO; R1 SIGNIFICA HIDROGENO O EL GRUPO METILO; R2 SIGNIFICA HIDROGENO, UN RADICAL ALCOHILO, ALGQUENILO O CICLOALQUILO; R Y R2 PUEDEN FORMAR, CONJUNTAMENTE CON EL ATOMO DE NITROGENO, UN ANILLO HETEROCICLICO. CONSISTE EN HACER REACCIONAR UN COMPUESTO 2-ACIL-BENZO[B]TIOFEN-3-OL, O UN ENOL-ETER, CON AMINAS DE FORMULA GENERAL (II), O CON SALES DE AMINO DE FORMULA GENERAL (III), O CON UREAS DE FORMULA GENERAL (IV), DONDE AR, R, R1 Y R2 TIENEN LOS SIGNIFICADOS YA INDICADOS; R3 SIGNIFICA UN GRUPO ALCOHILO, ALQUENILO O UN GRUPO FENILALCOHILO, Y B ELEVADO A - SIGNIFICA EL ANION DE UN ACIDO INORGANICO U ORGANICO, MONOBASICO O POLIBASICO, EN UN DISOLVENTE O EN UN EXCESO DEL COMPUESTO DE AMINAS DE FORMULA GENERAL (II) A TEMPERATURA COMPRENDIDA ENTRE -20G Y +60GC. DE USO EN PREPARADOS FARMACEUTICOS CON EFECTOS ANTICONVULSIVOS. *FORMULA* U
ES493852A 1979-07-31 1980-07-30 Procedimiento para la preparacion de nuevas carboxamidas vinilogas. Expired ES8106901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792931010 DE2931010A1 (de) 1979-07-31 1979-07-31 Neue vinyloge carboxamide, diese enthaltende arzneimittel und verfahren zur herstellung

Publications (2)

Publication Number Publication Date
ES493852A0 ES493852A0 (es) 1981-09-01
ES8106901A1 true ES8106901A1 (es) 1981-09-01

Family

ID=6077239

Family Applications (5)

Application Number Title Priority Date Filing Date
ES493852A Expired ES8106901A1 (es) 1979-07-31 1980-07-30 Procedimiento para la preparacion de nuevas carboxamidas vinilogas.
ES502015A Expired ES8202814A1 (es) 1979-07-31 1981-05-08 Procedimiento para la preparacion de nuevas carboxamidas vi-nilogas
ES502013A Expired ES8202812A1 (es) 1979-07-31 1981-05-08 Procedimiento para la preparacion de nuevas carboxamidas vi-nilogas
ES502014A Expired ES8202813A1 (es) 1979-07-31 1981-05-08 Procedimiento para la preparacion de nuevas carboxamidas vi-nilogas
ES502016A Expired ES8202815A1 (es) 1979-07-31 1981-05-08 Procedimiento para la preparacion de nuevas carboxamidas vi-nilogas

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES502015A Expired ES8202814A1 (es) 1979-07-31 1981-05-08 Procedimiento para la preparacion de nuevas carboxamidas vi-nilogas
ES502013A Expired ES8202812A1 (es) 1979-07-31 1981-05-08 Procedimiento para la preparacion de nuevas carboxamidas vi-nilogas
ES502014A Expired ES8202813A1 (es) 1979-07-31 1981-05-08 Procedimiento para la preparacion de nuevas carboxamidas vi-nilogas
ES502016A Expired ES8202815A1 (es) 1979-07-31 1981-05-08 Procedimiento para la preparacion de nuevas carboxamidas vi-nilogas

Country Status (15)

Country Link
US (1) US4288437A (es)
EP (1) EP0025489B1 (es)
JP (1) JPS5622778A (es)
AT (1) ATE4210T1 (es)
AU (1) AU538685B2 (es)
DE (2) DE2931010A1 (es)
DK (1) DK151962C (es)
ES (5) ES8106901A1 (es)
FI (1) FI71140C (es)
HK (1) HK50685A (es)
IE (1) IE50076B1 (es)
IL (1) IL60708A (es)
NO (1) NO151501C (es)
SG (1) SG385G (es)
ZA (1) ZA804643B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3212752A1 (de) * 1982-04-06 1983-10-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue vinyloge carboxamide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JP2002525295A (ja) * 1998-09-25 2002-08-13 バイロファーマ・インコーポレイテッド ウイルス感染および関連疾患の治療または予防法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2356824A (en) * 1941-05-01 1944-08-29 Du Pont Organic dyestuffs of the thionaphthenone series, and process of making the same
DE2258036A1 (de) * 1972-11-27 1974-05-30 Goedecke Ag Verfahren zur herstellung von benzo eckige klammer auf b eckige klammer zu thiophen-derivaten
LU76757A1 (es) * 1977-02-11 1978-10-18

Also Published As

Publication number Publication date
IE801596L (en) 1981-01-31
DE2931010A1 (de) 1981-02-26
AU538685B2 (en) 1984-08-23
DK326180A (da) 1981-02-01
ES502013A0 (es) 1982-03-01
ES502016A0 (es) 1982-03-01
EP0025489A1 (de) 1981-03-25
ES502015A0 (es) 1982-03-01
ZA804643B (en) 1982-04-28
EP0025489B1 (de) 1983-07-20
FI802366A (fi) 1981-02-01
ES8202814A1 (es) 1982-03-01
NO151501C (no) 1985-04-24
NO802292L (no) 1981-02-02
JPH0120155B2 (es) 1989-04-14
DK151962B (da) 1988-01-18
ES8202815A1 (es) 1982-03-01
US4288437A (en) 1981-09-08
ES502014A0 (es) 1982-03-01
IE50076B1 (en) 1986-02-05
ATE4210T1 (de) 1983-08-15
DE3064255D1 (en) 1983-08-25
FI71140B (fi) 1986-08-14
AU6093080A (en) 1981-02-05
DK151962C (da) 1988-06-20
SG385G (en) 1985-11-15
ES8202813A1 (es) 1982-03-01
ES493852A0 (es) 1981-09-01
JPS5622778A (en) 1981-03-03
HK50685A (en) 1985-07-12
ES8202812A1 (es) 1982-03-01
FI71140C (fi) 1986-11-24
IL60708A (en) 1984-05-31
NO151501B (no) 1985-01-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505