GB1355718A - 2-amino-5-chloro-thiazole derivatives - Google Patents

2-amino-5-chloro-thiazole derivatives

Info

Publication number
GB1355718A
GB1355718A GB2760271A GB2760271A GB1355718A GB 1355718 A GB1355718 A GB 1355718A GB 2760271 A GB2760271 A GB 2760271A GB 2760271 A GB2760271 A GB 2760271A GB 1355718 A GB1355718 A GB 1355718A
Authority
GB
United Kingdom
Prior art keywords
amino
chlorothiazole
general formula
reacting
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2760271A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melle Bezons SA
Original Assignee
Melle Bezons SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melle Bezons SA filed Critical Melle Bezons SA
Publication of GB1355718A publication Critical patent/GB1355718A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

1355718 2-Amino-5-chlorothiazole derivatives MELLE-BEZONS 11 June 1971 [11 June 1970] 27602/71 Heading C2C Novel 2-amino-5-chlorothiazole derivatives of the general formula wherein X is O or H 2 and each of R and R<SP>1</SP> is an alkyl, aralkyl, heterocyclic or (heterocyclo)alkyl group or R<SP>1</SP> may be a hydrogen atom or NRR<SP>1</SP> is a heterocyclic group, are prepared (a) when X is O, by reacting 2-chloracetamido-5-chlorothiazole with ammonia or an amine of the general formula R-NH-R<SP>1</SP>; (b) when X is O, by reacting 2-amino-5-chlorothiazole with a glycinyl chloride of the general formula RR<SP>1</SP>NCH 2 - COCl; (c) when X is H 2 , by reacting 2-amino-5- chlorothiazole with a 2-chloroethylamine of the general formula ClCH 2 CH 2 NRR<SP>1</SP>; and (d) when X is H 2 , by reacting N-[2-(2-chloroethyl)amino]- 5-chlorothiazole with an excess of ammonia or an amine of the general formula R-NH-R<SP>1</SP>. Pharmaceutical compositions having antiinflammatory, sedative, tranquillizing and analgesic activity comprise, as active ingredient, a 2-amino-5-chlorothiazole derivative of the first general formula above, in admixture with a pharmacologically acceptable carrier.
GB2760271A 1970-06-11 1971-06-11 2-amino-5-chloro-thiazole derivatives Expired GB1355718A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7021383A FR2092714B1 (en) 1970-06-11 1970-06-11

Publications (1)

Publication Number Publication Date
GB1355718A true GB1355718A (en) 1974-06-05

Family

ID=9056998

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2760271A Expired GB1355718A (en) 1970-06-11 1971-06-11 2-amino-5-chloro-thiazole derivatives

Country Status (5)

Country Link
JP (1) JPS504664B1 (en)
DE (1) DE2128941A1 (en)
ES (2) ES392093A1 (en)
FR (1) FR2092714B1 (en)
GB (1) GB1355718A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005070A2 (en) * 1978-04-24 1979-10-31 Pfizer Inc. N-(2-thiazolyl)amides and their use as anti-inflammatory and immunoregulatory agents

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS548367U (en) * 1977-06-20 1979-01-19
JPS5447361U (en) * 1977-09-08 1979-04-02
FR2572074B1 (en) * 1984-10-18 1987-07-17 Sanofi Sa THIADIAZOLE DERIVATIVES ACTIVE IN THE CENTRAL NERVOUS SYSTEM, PROCESS FOR OBTAINING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2612187B1 (en) * 1987-03-12 1989-07-21 Sanofi Sa THIAZOLE DERIVATIVES ACTIVE IN THE CHOLINERGIC SYSTEM, THEIR PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2618780B1 (en) * 1987-07-29 1989-12-08 Irceba THIAZOLE DERIVATIVES BELONGING TO THE FAMILY OF 2-PIPERAZINOACETAMIDO-4-METHYLTHIAZOLES, METHOD OF PREPARATION AND THERAPEUTIC USE
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
CA2503844A1 (en) * 2002-10-30 2004-05-21 Merck & Co., Inc. Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7428A (en) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0005070A2 (en) * 1978-04-24 1979-10-31 Pfizer Inc. N-(2-thiazolyl)amides and their use as anti-inflammatory and immunoregulatory agents
EP0005070A3 (en) * 1978-04-24 1979-11-28 Pfizer Inc. N-(2-thiazolyl)amides and their use as anti-inflammatory and immunoregulatory agents

Also Published As

Publication number Publication date
FR2092714A1 (en) 1972-01-28
ES392094A1 (en) 1974-08-01
ES392093A1 (en) 1974-10-01
JPS504664B1 (en) 1975-02-22
FR2092714B1 (en) 1974-03-22
DE2128941A1 (en) 1971-12-16

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees