ES8106274A1 - Un procedimiento para la preparacion de etanaminas. - Google Patents

Un procedimiento para la preparacion de etanaminas.

Info

Publication number
ES8106274A1
ES8106274A1 ES492489A ES492489A ES8106274A1 ES 8106274 A1 ES8106274 A1 ES 8106274A1 ES 492489 A ES492489 A ES 492489A ES 492489 A ES492489 A ES 492489A ES 8106274 A1 ES8106274 A1 ES 8106274A1
Authority
ES
Spain
Prior art keywords
group
hydrogen
atom
chlorine
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492489A
Other languages
English (en)
Other versions
ES492489A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8106274A1 publication Critical patent/ES8106274A1/es
Publication of ES492489A0 publication Critical patent/ES492489A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/17—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to acyclic carbon atoms and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/32—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to acyclic carbon atoms and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/42—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrolysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ETANAMINAS DE FORMULA GENERAL (I), QUE PUEDE ESTAR EN FORMA DE UN SOLO ISOMERO, O EN FORMA DE UNA MEZCLA DE ESTEREOISOMEROS, O BIEN DONDE TAL COMPUESTO DE FORMULA GENERAL (I) TIENE DOS CENTROS DE ASIMETRIA Y SE PROPORCIONA COMO UN DIASTEREOISOMERO SEPARADO; DONDE R1 ES UN ATOMO DE H,F,CL,BR, O UN GRUPO TRIFLUOROMETILO, HIDROXIMETILO, HIDROXILO O AMINO; R2 ES UN ATOMO DE H,F,CL,BR O UN GRUPO DE HIDROXILO; R3 ES UN ATOMO DE H,CL,BR, O UN GRUPO HIDROXILO; R4 Y R5 SON O UN ATOMO DE H O UN GRUPO METILO; R6 ES UN ATOMO DE H,F,CL, O UN GRUPO METILO, METOXILO O HIDROXI; X ES UN ATOMO DE O, O UN ENLACE, *FORMULA* CONSISTENTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) CON OTRO DE FORMULA GENERAL (III), DONDE A ES -CH-CH2, -CHOH-CH2-NH2, O -CO-CHO Y B ES NH2-CR5R4-, O R4-CO-, SIENDO LOS DEMAS RADICALES ANALOGOS A LOS YA INDICADOS. EN EL CASO DE SER A DISTINTO DE -CH-CH2, SE DEBE REDUCIR EL COMPUESTO ANTERIORMENTE OBTENIDO.
ES492489A 1979-06-16 1980-06-16 Un procedimiento para la preparacion de etanaminas. Granted ES492489A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7921038 1979-06-16

Publications (2)

Publication Number Publication Date
ES8106274A1 true ES8106274A1 (es) 1981-08-01
ES492489A0 ES492489A0 (es) 1981-08-01

Family

ID=10505899

Family Applications (2)

Application Number Title Priority Date Filing Date
ES492489A Granted ES492489A0 (es) 1979-06-16 1980-06-16 Un procedimiento para la preparacion de etanaminas.
ES499604A Granted ES499604A0 (es) 1979-06-16 1981-02-19 Un procedimiento para la preparacion de etanaminas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES499604A Granted ES499604A0 (es) 1979-06-16 1981-02-19 Un procedimiento para la preparacion de etanaminas

Country Status (14)

Country Link
US (1) US4338333A (es)
EP (1) EP0023385B1 (es)
JP (1) JPS565444A (es)
AT (1) ATE1994T1 (es)
AU (1) AU533432B2 (es)
CA (1) CA1150297A (es)
DE (1) DE3061334D1 (es)
DK (1) DK256580A (es)
ES (2) ES492489A0 (es)
IE (1) IE49908B1 (es)
IL (1) IL60288A0 (es)
MY (1) MY8500997A (es)
NZ (1) NZ193988A (es)
ZA (1) ZA803576B (es)

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GB8415377D0 (en) * 1984-06-15 1984-07-18 Beecham Group Plc Compounds
IN165525B (es) 1984-07-23 1989-11-04 Shinetsu Chemical Co
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DE3631009A1 (de) * 1986-09-12 1988-03-24 Bayer Ag Arylethanolamine, verfahren zu ihrer herstellung und ihre verwendung zur leistungsfoerderung
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US9784726B2 (en) 2013-01-08 2017-10-10 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

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Also Published As

Publication number Publication date
US4338333A (en) 1982-07-06
DE3061334D1 (en) 1983-01-20
IE801223L (en) 1980-12-16
ZA803576B (en) 1981-06-24
ES8202533A1 (es) 1982-02-01
AU533432B2 (en) 1983-11-24
AU5930780A (en) 1981-01-08
NZ193988A (en) 1984-11-09
IE49908B1 (en) 1986-01-08
JPS565444A (en) 1981-01-20
MY8500997A (en) 1985-12-31
DK256580A (da) 1980-12-17
IL60288A0 (en) 1980-09-16
EP0023385B1 (en) 1982-12-15
ES492489A0 (es) 1981-08-01
ATE1994T1 (de) 1982-12-15
EP0023385A1 (en) 1981-02-04
CA1150297A (en) 1983-07-19
JPS6326744B2 (es) 1988-05-31
ES499604A0 (es) 1982-02-01

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Legal Events

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FD1A Patent lapsed

Effective date: 19990301