ES8105682A1 - Un procedimiento para preparar complejos de platino - Google Patents

Un procedimiento para preparar complejos de platino

Info

Publication number
ES8105682A1
ES8105682A1 ES494267A ES494267A ES8105682A1 ES 8105682 A1 ES8105682 A1 ES 8105682A1 ES 494267 A ES494267 A ES 494267A ES 494267 A ES494267 A ES 494267A ES 8105682 A1 ES8105682 A1 ES 8105682A1
Authority
ES
Spain
Prior art keywords
platinum complexes
preparing platinum
cis
preparing
k2pti4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494267A
Other languages
English (en)
Other versions
ES494267A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MPD Technology Corp
Original Assignee
MPD Technology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MPD Technology Corp filed Critical MPD Technology Corp
Publication of ES8105682A1 publication Critical patent/ES8105682A1/es
Publication of ES494267A0 publication Critical patent/ES494267A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G55/00—Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
    • C01G55/002—Compounds containing, besides ruthenium, rhodium, palladium, osmium, iridium, or platinum, two or more other elements, with the exception of oxygen or hydrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/32—Thermal properties
    • C01P2006/37—Stability against thermal decomposition
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/60—Optical properties, e.g. expressed in CIELAB-values
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
    • C01P2006/80—Compositional purity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE CIS-DIAMINODICLOROPLATINO (II) Y DE LOS COMPUESTOS INTERMEDIOS PRODUCIDOS. A UNA DISPERSION ACUOSA DE M2PTI4, DONDE M ES SODIO O POTASIO, SE AÑADE LENTAMENTE Y CON AGITACION UNA DISOLUCION ACUOSA DE HIDROXIDO AMONICO, DE MODO QUE EL PH NO EXCEDA DE 7,5, MANTENIENDO LA TEMPERATURA ENTRE 40 Y 60 GC POR AUMENTO GRADUAL DE LA MISMA DENTRO DE ESTE INTERVALO. EL CIS-DIAMINOYODOPLATINO (II)OBTENIDO SE PUEDE SEPARAR Y PURIFICAR, O TRATAR CON UNA DISOLUCION ACUOSA DE NITRATO DE PLATA A TEMPERATURA AMBIENTE Y POSTERIOR CALENTAMIENTO A 50 GC PARA OBTENER EL NITRATO DE CIS-DIAMINODIACUOPLATINO (II), QUE SE PUEDE SEPARAR Y PURIFICAR DESPUES DE ELIMINAR EL ION AG+ PRECIPITANDO CON CLORURO ALCALINO. A UNA DISOLUCION ACUOSA DE ESTE NITRATO DEL COMPLEJO SE AÑADE RAPIDAMENTE CLORURO ALCALINO Y SE CALIENTA A 65-75 GC HASTA QUE SE COMPLETA LA REACCION. EL PRODUCTO SE RECRISTALIZA EN MEDIO CLORHIDRICO EL M2PTI4 SE OBTIENE POR TRATAMIENTO CON IK DE UNA DISOLUCION ACUOSA DE M2PTCL4. EL CIS-DIAMINODICLOROPLATINO (II) SE APLICA EN LA TERAPEUTICA DEL CANCER. T
ES494267A 1979-08-16 1980-08-14 Un procedimiento para preparar complejos de platino Granted ES494267A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/065,553 US4273755A (en) 1979-08-16 1979-08-16 Preparation of platinum complexes

Publications (2)

Publication Number Publication Date
ES8105682A1 true ES8105682A1 (es) 1981-06-16
ES494267A0 ES494267A0 (es) 1981-06-16

Family

ID=22063515

Family Applications (1)

Application Number Title Priority Date Filing Date
ES494267A Granted ES494267A0 (es) 1979-08-16 1980-08-14 Un procedimiento para preparar complejos de platino

Country Status (14)

Country Link
US (1) US4273755A (es)
EP (1) EP0030782B1 (es)
JP (1) JPS5654233A (es)
AR (1) AR227647A1 (es)
AT (1) ATE5874T1 (es)
AU (1) AU6092280A (es)
CA (1) CA1156429A (es)
DE (1) DE3066179D1 (es)
DK (1) DK353980A (es)
ES (1) ES494267A0 (es)
FI (1) FI802521A (es)
IN (1) IN154936B (es)
NO (1) NO802440L (es)
ZA (1) ZA804601B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335087A (en) * 1979-08-16 1982-06-15 Mpd Technology Corporation Process for preparing cis-Pt(NH3)2 Cl2
US4302446A (en) * 1979-10-02 1981-11-24 Bristol-Myers Company Pharmaceutical compositions
US4645666A (en) * 1982-06-08 1987-02-24 The Regents Of The University Of California Vaccine for bluetongue disease employing platinum compounds
IT1153974B (it) * 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
DE3305248A1 (de) * 1983-02-16 1984-08-16 Degussa Ag, 6000 Frankfurt Verfahren zur herstellung von reinem cis-platin-(ii)-diammin-dichlorid
US4699978A (en) * 1985-01-18 1987-10-13 The Trustees Of Columbia University In The City Of New York Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US4946689A (en) * 1988-11-23 1990-08-07 Bristol-Myers Company Concentrated, stabilized cis-diamminedinitratoplatinum solutions for conversion to cisplatin
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
US20100034874A1 (en) * 2006-12-08 2010-02-11 Katayama Chemical Industries Co., Ltd. Liposome encapsulating ammine-platinum complex at high concentration, and method for production of the liposome
CZ302618B6 (cs) 2009-09-10 2011-08-03 Univerzita Palackého Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, zpusoby jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii
RU2538895C2 (ru) * 2013-02-18 2015-01-10 Федеральное государственное бюджетное учреждение науки Институт неорганической химии им. А.В. Николаева Сибирского отделения Российской академии наук (ИНХ СО РАН) Способ получения цис-дихлородиамминплатины (ii)
CN103739631A (zh) * 2014-01-22 2014-04-23 上海金和生物技术有限公司 一种抗肿瘤药物卡铂的制备方法
WO2016142199A1 (de) 2015-03-06 2016-09-15 Umicore Ag & Co. Kg Metallorganische verbindung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053587A (en) * 1973-04-13 1977-10-11 Research Corporation Method of treating viral infections
US4079121A (en) * 1974-12-13 1978-03-14 Mobil Oil Corporation Complexes of beta platinum chloride and ammonia
ES472342A1 (es) 1978-08-04 1979-03-16 Espanola Farma Therapeut Procedimiento para la obtencion de un derivado diamonico

Also Published As

Publication number Publication date
JPS5654233A (en) 1981-05-14
DE3066179D1 (en) 1984-02-23
CA1156429A (en) 1983-11-08
EP0030782A1 (en) 1981-06-24
NO802440L (no) 1981-02-17
FI802521A (fi) 1981-02-17
ZA804601B (en) 1981-07-29
IN154936B (es) 1984-12-22
ATE5874T1 (de) 1984-02-15
ES494267A0 (es) 1981-06-16
AR227647A1 (es) 1982-11-30
AU6092280A (en) 1981-02-19
EP0030782B1 (en) 1984-01-18
DK353980A (da) 1981-02-17
US4273755A (en) 1981-06-16

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