ES8105000A1 - Procedimiento para la preparacion de un derivado de acido 2-hidroxi-5-(1-hidroxi-2-(4-(2-oxo-1-bencimidazolinil)piperi- dino)etil)benzoico - Google Patents

Procedimiento para la preparacion de un derivado de acido 2-hidroxi-5-(1-hidroxi-2-(4-(2-oxo-1-bencimidazolinil)piperi- dino)etil)benzoico

Info

Publication number
ES8105000A1
ES8105000A1 ES490666A ES490666A ES8105000A1 ES 8105000 A1 ES8105000 A1 ES 8105000A1 ES 490666 A ES490666 A ES 490666A ES 490666 A ES490666 A ES 490666A ES 8105000 A1 ES8105000 A1 ES 8105000A1
Authority
ES
Spain
Prior art keywords
hydroxy
benzimidazolinyl
piperidino
oxo
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490666A
Other languages
English (en)
Other versions
ES490666A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ES490666A0 publication Critical patent/ES490666A0/es
Publication of ES8105000A1 publication Critical patent/ES8105000A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE ACIDO 2-HIDROXI-5-(1-HIDROXI-2-(4-(2-OXO-1-BENCIMIDAZOLINIL)-PIPERIDINO)ETIL) BENZOICO DE FORMULA (I), DONDE X PUEDE SER DISTINTOS TIPOS DE RADICALES, R1 ES HIDROGENO, METILO Y ETILO; R2 Y R3 SON HIDROGENO, Y CUANDO SE TOMAN JUNTOS FORMAN UN DOBLE ENLACE, O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE PRIMERAMENTE EN CONDENSAR, EN UN DISOLVENTE ANHIDRO, UN DERIVADO DE ACIDO 2-HIDROXI-5-(2-BROMOACETIL-BENZOICO DE FOMULA (II) CON UNA 4-(2-OXO-1-BENCIMIDAZOLINIL)PIPERIDINA DE FORMULA (III), CON LO CUAL SE OBTIENE UN DERIVADO DE 2-HIDROXI-5-(4-(2-OXO-1-BENCIMIDAZOLINIL PIPERIDINOACETIL BENZOICO. POSTERIORMENTE TIENE LUGAR LA REDUCCION DE LA SOLUCION Y EL AISLAMIENTO DEL COMPUESTO DESEADO. ESTOS DERIVADOS TIENEN APLICACIONES FARMACOLOGICAS. *FORMULA*
ES490666A 1979-05-04 1980-04-17 Procedimiento para la preparacion de un derivado de acido 2-hidroxi-5-(1-hidroxi-2-(4-(2-oxo-1-bencimidazolinil)piperi- dino)etil)benzoico Expired ES8105000A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/036,245 US4200755A (en) 1979-05-04 1979-05-04 2-Hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid derivatives

Publications (2)

Publication Number Publication Date
ES490666A0 ES490666A0 (es) 1981-05-16
ES8105000A1 true ES8105000A1 (es) 1981-05-16

Family

ID=21887509

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490666A Expired ES8105000A1 (es) 1979-05-04 1980-04-17 Procedimiento para la preparacion de un derivado de acido 2-hidroxi-5-(1-hidroxi-2-(4-(2-oxo-1-bencimidazolinil)piperi- dino)etil)benzoico

Country Status (21)

Country Link
US (1) US4200755A (es)
JP (1) JPS55153783A (es)
AT (1) AT375362B (es)
AU (1) AU530654B2 (es)
BE (1) BE883085A (es)
CA (1) CA1138874A (es)
CH (1) CH645373A5 (es)
DE (1) DE3013928A1 (es)
DK (1) DK193380A (es)
ES (1) ES8105000A1 (es)
FR (1) FR2455599A1 (es)
GB (1) GB2053194B (es)
IE (1) IE49646B1 (es)
IL (1) IL59580A (es)
IT (1) IT1146156B (es)
NL (1) NL8002070A (es)
NO (1) NO152559C (es)
NZ (1) NZ193084A (es)
PH (1) PH15418A (es)
SE (1) SE441447B (es)
ZA (1) ZA801429B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264613A (en) * 1979-08-01 1981-04-28 Science Union Et Cie, Societe Francaise De Recherche Medicale Piperidylbenzimidazolinone compounds
FR2469411A1 (fr) * 1979-11-15 1981-05-22 Science Union & Cie Nouveaux derives de la piperidylbenzimidazolinone, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
JPS58180481A (ja) * 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (es) * 1962-06-13
US3318900A (en) * 1964-05-06 1967-05-09 Janssen Pharmaceutica Nv Derivatives of benzimidazolinyl piperidine
US4080328A (en) * 1971-07-13 1978-03-21 Sumitomo Chemical Company, Limited N-substituted heterocyclic derivatives and preparation thereof
US3818017A (en) * 1973-01-04 1974-06-18 Janssen Pharmaceutica Nv 1-{8 1-(2-hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds
US3894030A (en) * 1973-01-04 1975-07-08 Janssen Pharmaceutica Nv 1-{8 1-(2-Hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds
US3929801A (en) * 1973-11-20 1975-12-30 Janssen Pharmaceutica Nv 2-Benzimidazolinones
JPS51125239A (en) * 1975-03-05 1976-11-01 Sumitomo Chem Co Ltd Process for preparing new bytyrophenone derivatives
JPS5227775A (en) * 1975-08-28 1977-03-02 Sumitomo Chem Co Ltd Preparation of novel acylhydrazone derivatives and their salts
JPS5359675A (en) * 1976-11-08 1978-05-29 Yoshitomi Pharmaceut Ind Ltd Aminoalcohol derivatives
GR69650B (es) * 1978-07-20 1982-07-07 Science Union & Cie

Also Published As

Publication number Publication date
NO801298L (no) 1980-11-05
ES490666A0 (es) 1981-05-16
AU5620280A (en) 1980-11-06
IL59580A0 (en) 1980-06-30
ATA232480A (de) 1983-12-15
BE883085A (fr) 1980-09-01
JPS55153783A (en) 1980-11-29
FR2455599B1 (es) 1983-09-23
CH645373A5 (de) 1984-09-28
IT8048188A0 (it) 1980-03-18
NO152559B (no) 1985-07-08
FR2455599A1 (fr) 1980-11-28
IE800442L (en) 1980-11-04
AU530654B2 (en) 1983-07-21
NO152559C (no) 1985-10-16
NL8002070A (nl) 1980-11-06
PH15418A (en) 1983-01-07
IT1146156B (it) 1986-11-12
GB2053194B (en) 1982-11-17
IE49646B1 (en) 1985-11-13
ZA801429B (en) 1980-12-31
SE8003245L (sv) 1980-11-05
IL59580A (en) 1984-05-31
CA1138874A (en) 1983-01-04
SE441447B (sv) 1985-10-07
AT375362B (de) 1984-07-25
DE3013928A1 (de) 1980-11-13
GB2053194A (en) 1981-02-04
DK193380A (da) 1980-11-05
NZ193084A (en) 1982-06-29
US4200755A (en) 1980-04-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020304