ES8104995A1 - Procedimiento para la preparacion de un derivado de 2-hidro-xi-5-(1-hidroxi-2-piperaciniletil)benzoico - Google Patents

Procedimiento para la preparacion de un derivado de 2-hidro-xi-5-(1-hidroxi-2-piperaciniletil)benzoico

Info

Publication number
ES8104995A1
ES8104995A1 ES490667A ES490667A ES8104995A1 ES 8104995 A1 ES8104995 A1 ES 8104995A1 ES 490667 A ES490667 A ES 490667A ES 490667 A ES490667 A ES 490667A ES 8104995 A1 ES8104995 A1 ES 8104995A1
Authority
ES
Spain
Prior art keywords
hydroxy
piperazinylethyl
benzoic acid
acid derivatives
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490667A
Other languages
English (en)
Other versions
ES490667A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ES8104995A1 publication Critical patent/ES8104995A1/es
Publication of ES490667A0 publication Critical patent/ES490667A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DE ACIDO 2-HIDROXI-5-(1-HIDROXI-5-(1-HIDROXI-2-PIPERACINILETIL)BENZOICO DE FORMULA (I), O UNA DE SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES, DONDE R2 Y X PUEDEN SER DISTINTOS TIPOS DE RADICALES; R1 ES HIDROGENO, METILO O ETILO. CONSISTE EN CONDENSAR EN UN DISOLVENTE ANHIDRO UN ACIDO 2-HIDROXI-5-(2-BROMOACETIL)BENZOICO DE FORMULA (II) CON UNA 1-(SUSTITUIDA)PIPERACINA DE FORMULA (II), CON LO QUE SE OBTIENE EL COMPUESTO (IV) QUE SE REDUCE CATALITICAMENTE Y SE AISLA EL DERIVADO DESEADO. ESTOS COMPUESTOS POSEEN ACTIVIDAD BLOQUEADORA RECEPTORA ALFA Y BETA-ADRENERGICA Y SON UTILES EN EL TRATAMIENTO O EN LA PROFILAXIS DE DESORDENES CARDIOVASCULARES. *FORMULA*
ES490667A 1979-05-04 1980-04-17 Procedimiento para la preparacion de un derivado de 2-hidro-xi-5-(1-hidroxi-2-piperaciniletil)benzoico Granted ES490667A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/036,244 US4255575A (en) 1979-05-04 1979-05-04 2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives

Publications (2)

Publication Number Publication Date
ES8104995A1 true ES8104995A1 (es) 1981-05-16
ES490667A0 ES490667A0 (es) 1981-05-16

Family

ID=21887503

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490667A Granted ES490667A0 (es) 1979-05-04 1980-04-17 Procedimiento para la preparacion de un derivado de 2-hidro-xi-5-(1-hidroxi-2-piperaciniletil)benzoico

Country Status (21)

Country Link
US (1) US4255575A (es)
JP (1) JPS55147262A (es)
AT (1) AT376426B (es)
AU (1) AU531738B2 (es)
BE (1) BE883086A (es)
CA (1) CA1138457A (es)
CH (1) CH645368A5 (es)
DE (1) DE3014813A1 (es)
DK (1) DK159435C (es)
ES (1) ES490667A0 (es)
FR (1) FR2455590A1 (es)
GB (1) GB2053897B (es)
IE (1) IE49549B1 (es)
IL (1) IL59596A (es)
IT (1) IT1143190B (es)
NL (1) NL8002071A (es)
NO (1) NO152698C (es)
NZ (1) NZ193107A (es)
PH (1) PH17089A (es)
SE (1) SE447109B (es)
ZA (1) ZA801453B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3400168A1 (de) * 1984-01-04 1985-07-11 Bayer Ag, 5090 Leverkusen 5-halogenalkyl-1,3,4-thiadiazol-2-yloxyacetamide
US4616017A (en) * 1984-06-04 1986-10-07 Merck & Co., Inc. Aminohydroxypropoxy substituted aryl compounds
DE3505425A1 (de) * 1985-02-16 1986-08-21 Bayer Ag, 5090 Leverkusen 5-chlor-1,3,4-thiadiazol-2-yloxy-acetamide
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
US4956302A (en) 1987-09-11 1990-09-11 Abbott Laboratories Lateral flow chromatographic binding assay device
DE3812755A1 (de) * 1988-04-16 1989-10-26 Merck Patent Gmbh Salicylsaeurederivate
KR100484386B1 (ko) * 2000-10-04 2005-04-22 경동제약 주식회사 알킬2-[2,3,5-트리플루오로-4-(4-메틸-1-피페라지닐)]벤조일-3(ｓ)-(1-히드록시프로피-2-닐아미노)아크릴레이트의 제조방법
US20080131954A1 (en) * 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317479A (en) * 1970-11-10 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
CA1113937A (en) * 1977-04-05 1981-12-08 Frederic P. Hauck Substituted piperidinylpropanols

Also Published As

Publication number Publication date
GB2053897B (en) 1982-10-20
FR2455590B1 (es) 1983-10-14
NO152698B (no) 1985-07-29
DK193680A (da) 1980-11-05
JPS55147262A (en) 1980-11-17
ZA801453B (en) 1980-12-31
AU5707680A (en) 1980-11-06
US4255575A (en) 1981-03-10
FR2455590A1 (fr) 1980-11-28
DK159435C (da) 1991-03-25
BE883086A (fr) 1980-09-01
IE800481L (en) 1980-11-04
GB2053897A (en) 1981-02-11
AT376426B (de) 1984-11-26
DK159435B (da) 1990-10-15
NL8002071A (nl) 1980-11-06
NO152698C (no) 1985-11-20
NZ193107A (en) 1982-12-21
CA1138457A (en) 1982-12-28
ES490667A0 (es) 1981-05-16
ATA232580A (de) 1984-04-15
DE3014813A1 (de) 1980-11-13
JPS6321666B2 (es) 1988-05-09
CH645368A5 (de) 1984-09-28
IL59596A0 (en) 1980-06-30
IT1143190B (it) 1986-10-22
SE8003244L (sv) 1980-11-05
IL59596A (en) 1984-01-31
SE447109B (sv) 1986-10-27
AU531738B2 (en) 1983-09-01
IE49549B1 (en) 1985-10-30
PH17089A (en) 1984-05-29
IT8048267A0 (it) 1980-03-26
NO801297L (no) 1980-11-05

Similar Documents

Publication Publication Date Title
AR240929A1 (es) "n-piridinsulfonil-n'-piridinil-y-triazinil-ureas procedimiento parasu preparacion, intermediarios para uso exclusivo en dicho procedimiento, y composiciones que contienen dichas ureas"
DZ253A1 (fr) Nouveau dérivés du 1,2,4, triazole, leur préparation et leur utilisation comme agents fongicides.
AR240922A1 (es) "procedimiento para preparar acilureidoalquil-bencensulfo-nilureas".
TR20075A (tr) Aktif-madde olarak x-siyano 3-fenoksibenzil-2-(4-klorofenil)-isovalerat'in optikce aktif bir isomerini muhtevi ensektisid
MX9202639A (es) Nuevos derivados del acido 2,4,6-triyodo-isoftalico y composiciones de contraste que los contienen.
IT1116741B (it) Nitrofenoli sostituiti,procedimento per la loro preparazione e composizioni tintorie
ES8104995A1 (es) Procedimiento para la preparacion de un derivado de 2-hidro-xi-5-(1-hidroxi-2-piperaciniletil)benzoico
MY100900A (en) Substituted phenylsulfonyloxybenzimidazolecarbamates, processes for their preparation and their use as medicaments.
AR223695A1 (es) Nuevos derivados n-fenil-n'benzoilurea,procedimientos para prepararlo y composiciones insecticidas que los contienen
AR228011A1 (es) Procedimiento para la preparacion de derivados sustituidos de 2,5,5,8a-tetrametil-1,2,3,4,4a,5,6,7,8,8a-decahidronaftaleno-1-spiro-2'-(4',6',7'-sustituido-2',3'-dihidrobenzofurano)
AR240809A1 (es) Compuestos de imidazolidinonas e imidazolidintionas, composicion herbicida que los comprende y procedimiento para su preparacion
TR21627A (tr) Yeni azolilbutanoller,bunlari hazirlamaya mahsus usuller ve bunlarin bitki koruma maddeleri olarak kullanimi
AR231988A1 (es) Nuevos compuestos s-alquil(c-c)-s-alquilo(c-c)ramificado-alquil(c-c)fosfonotritioatos,composicion que los contiene,y metodo para prepararlos;y nuevos haluros s-alquil ramificado-alquilfosfono-diioico y metodo para prepararlos
AR240400A1 (es) Procedimiento para obtener nuevas composiciones sinergicas para uso veterinario.
IT1172352B (it) Composti poliazoici,loro preparazione e loro impiego come coloranti
IL51688A0 (en) Polycyclic nitrogen-containing compounds and their use as crop protection agents
TR21769A (tr) Yeni suebstituee edilmis 1-fenil-3-benzoil-(tio)uereler,hazirlanmalari icin yoentemler ve zararhlarla muecadele vasitalari olarak kullanilmalari
ES8105000A1 (es) Procedimiento para la preparacion de un derivado de acido 2-hidroxi-5-(1-hidroxi-2-(4-(2-oxo-1-bencimidazolinil)piperi- dino)etil)benzoico
IT8449267A0 (it) Composti bisazoici,loro preparazione e loro impiego come coloranti
ES526026A0 (es) Un procedimiento para preparar nuevos derivados de acido -aril- -piridilalcanoico
AR225346A1 (es) Procedimiento para preparar sales de 4'-(9-acridinilamino)metansulfon-c-anisidida
IT1214672B (it) Composti monoazoici,loro preparazione e loro impiego come coloranti re attivi
IT1197547B (it) Composti monoazoici,loro preparazione e loro impiego come coloranti
AR229873A1 (es) Procedimiento para la preparacion de nuevos 3-2-hidroxi-fenil-4-sustituido-4 o 5-sustituido cicloalcanoles y derivados de los mismos,utiles como agentes analgesicos y como agentes antiemeticos y compuestos intermedios utilizados
IT8321046A0 (it) Disposizione ad uso delle apparecchiature per l'avanzamento dei tronchi.

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020304