IT1143190B - Derivati di acido 2-idrossi-5-(1-idrossi-2-piperaziniletil)-benzoico e procedimento per la loro preparazione - Google Patents

Derivati di acido 2-idrossi-5-(1-idrossi-2-piperaziniletil)-benzoico e procedimento per la loro preparazione

Info

Publication number
IT1143190B
IT1143190B IT48267/80A IT4826780A IT1143190B IT 1143190 B IT1143190 B IT 1143190B IT 48267/80 A IT48267/80 A IT 48267/80A IT 4826780 A IT4826780 A IT 4826780A IT 1143190 B IT1143190 B IT 1143190B
Authority
IT
Italy
Prior art keywords
hydroxy
piperazinylethyl
procedure
preparation
benzoic acid
Prior art date
Application number
IT48267/80A
Other languages
English (en)
Other versions
IT8048267A0 (it
Inventor
Martin J Grisar
George P Claxton
Original Assignee
Merrell Inc Richard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Inc Richard filed Critical Merrell Inc Richard
Publication of IT8048267A0 publication Critical patent/IT8048267A0/it
Application granted granted Critical
Publication of IT1143190B publication Critical patent/IT1143190B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT48267/80A 1979-05-04 1980-03-26 Derivati di acido 2-idrossi-5-(1-idrossi-2-piperaziniletil)-benzoico e procedimento per la loro preparazione IT1143190B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/036,244 US4255575A (en) 1979-05-04 1979-05-04 2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives

Publications (2)

Publication Number Publication Date
IT8048267A0 IT8048267A0 (it) 1980-03-26
IT1143190B true IT1143190B (it) 1986-10-22

Family

ID=21887503

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48267/80A IT1143190B (it) 1979-05-04 1980-03-26 Derivati di acido 2-idrossi-5-(1-idrossi-2-piperaziniletil)-benzoico e procedimento per la loro preparazione

Country Status (21)

Country Link
US (1) US4255575A (it)
JP (1) JPS55147262A (it)
AT (1) AT376426B (it)
AU (1) AU531738B2 (it)
BE (1) BE883086A (it)
CA (1) CA1138457A (it)
CH (1) CH645368A5 (it)
DE (1) DE3014813A1 (it)
DK (1) DK159435C (it)
ES (1) ES8104995A1 (it)
FR (1) FR2455590A1 (it)
GB (1) GB2053897B (it)
IE (1) IE49549B1 (it)
IL (1) IL59596A (it)
IT (1) IT1143190B (it)
NL (1) NL8002071A (it)
NO (1) NO152698C (it)
NZ (1) NZ193107A (it)
PH (1) PH17089A (it)
SE (1) SE447109B (it)
ZA (1) ZA801453B (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3400168A1 (de) * 1984-01-04 1985-07-11 Bayer Ag, 5090 Leverkusen 5-halogenalkyl-1,3,4-thiadiazol-2-yloxyacetamide
US4616017A (en) * 1984-06-04 1986-10-07 Merck & Co., Inc. Aminohydroxypropoxy substituted aryl compounds
DE3505425A1 (de) * 1985-02-16 1986-08-21 Bayer Ag, 5090 Leverkusen 5-chlor-1,3,4-thiadiazol-2-yloxy-acetamide
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
US4956302A (en) * 1987-09-11 1990-09-11 Abbott Laboratories Lateral flow chromatographic binding assay device
DE3812755A1 (de) * 1988-04-16 1989-10-26 Merck Patent Gmbh Salicylsaeurederivate
KR100484386B1 (ko) * 2000-10-04 2005-04-22 경동제약 주식회사 알킬2-[2,3,5-트리플루오로-4-(4-메틸-1-피페라지닐)]벤조일-3(s)-(1-히드록시프로피-2-닐아미노)아크릴레이트의 제조방법
US20080131954A1 (en) * 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317479A (en) * 1970-11-10 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
CA1113937A (en) * 1977-04-05 1981-12-08 Frederic P. Hauck Substituted piperidinylpropanols

Also Published As

Publication number Publication date
ZA801453B (en) 1980-12-31
NO152698B (no) 1985-07-29
DE3014813A1 (de) 1980-11-13
JPS6321666B2 (it) 1988-05-09
CH645368A5 (de) 1984-09-28
NO801297L (no) 1980-11-05
DK159435B (da) 1990-10-15
BE883086A (fr) 1980-09-01
AT376426B (de) 1984-11-26
DK193680A (da) 1980-11-05
US4255575A (en) 1981-03-10
NO152698C (no) 1985-11-20
FR2455590B1 (it) 1983-10-14
ATA232580A (de) 1984-04-15
SE447109B (sv) 1986-10-27
CA1138457A (en) 1982-12-28
IE49549B1 (en) 1985-10-30
GB2053897B (en) 1982-10-20
ES490667A0 (es) 1981-05-16
SE8003244L (sv) 1980-11-05
DK159435C (da) 1991-03-25
PH17089A (en) 1984-05-29
AU5707680A (en) 1980-11-06
AU531738B2 (en) 1983-09-01
IT8048267A0 (it) 1980-03-26
FR2455590A1 (fr) 1980-11-28
IL59596A (en) 1984-01-31
IE800481L (en) 1980-11-04
NL8002071A (nl) 1980-11-06
GB2053897A (en) 1981-02-11
NZ193107A (en) 1982-12-21
JPS55147262A (en) 1980-11-17
ES8104995A1 (es) 1981-05-16
IL59596A0 (en) 1980-06-30

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Effective date: 19990331