ES542290A0 - Un procedimiento para la preparacion de derivados de adenosina v-6 monosustituidos. - Google Patents
Un procedimiento para la preparacion de derivados de adenosina v-6 monosustituidos.Info
- Publication number
- ES542290A0 ES542290A0 ES85542290A ES542290A ES542290A0 ES 542290 A0 ES542290 A0 ES 542290A0 ES 85542290 A ES85542290 A ES 85542290A ES 542290 A ES542290 A ES 542290A ES 542290 A0 ES542290 A0 ES 542290A0
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- lower alkyl
- ribofuranosyl
- purine
- beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003835 adenosine derivatives Chemical class 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- MRWXACSTFXYYMV-UHFFFAOYSA-N Nebularine Natural products OC1C(O)C(CO)OC1N1C2=NC=NC=C2N=C1 MRWXACSTFXYYMV-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 monosubstituted adenosine Chemical class 0.000 abstract 3
- 230000000747 cardiac effect Effects 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60143584A | 1984-04-18 | 1984-04-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8707544A1 ES8707544A1 (es) | 1987-08-01 |
ES542290A0 true ES542290A0 (es) | 1987-08-01 |
Family
ID=24407470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES542290A Expired ES8707544A1 (es) | 1984-04-18 | 1985-04-16 | Un procedimiento para la preparacion de derivados de adenosina v-6 monosustituidos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5043325A (es) |
EP (4) | EP0305643B1 (es) |
JP (1) | JPH0655756B2 (es) |
AT (2) | ATE50777T1 (es) |
AU (1) | AU582359B2 (es) |
CA (4) | CA1279063C (es) |
DE (2) | DE3587717T2 (es) |
ES (1) | ES8707544A1 (es) |
IE (3) | IE60213B1 (es) |
WO (1) | WO1985004882A1 (es) |
ZA (1) | ZA852746B (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5310731A (en) * | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
AU575438B2 (en) * | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
AU8274187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
US5063233A (en) * | 1986-11-14 | 1991-11-05 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists |
US4954504A (en) * | 1986-11-14 | 1990-09-04 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity |
US4968697A (en) * | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
US5034381A (en) * | 1988-01-07 | 1991-07-23 | Ciba-Geigy Corporation | 2-(substituted amino) adenosines as antihypertensives |
ZA902280B (en) * | 1989-03-29 | 1990-12-28 | Merrell Dow Pharma | Selective adenosine receptor agents |
US5256650A (en) * | 1989-03-29 | 1993-10-26 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine receptor agents |
US5391739A (en) * | 1989-03-29 | 1995-02-21 | Merrell Dow Pharmaceuticals Inc. | Selective adenosine receptor agents |
US5017578A (en) * | 1989-06-09 | 1991-05-21 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents |
US5155098A (en) * | 1989-06-09 | 1992-10-13 | Hoechst-Roussel Pharmaceuticals Inc. | N-heteroaryl-purin-6-amines, and pharmaceutical compositions and methods employing them |
GB9011623D0 (en) * | 1990-05-24 | 1990-07-11 | Efamol Holdings | Synthesis of nucleotide and nucleoside derivatives |
US5430138A (en) * | 1990-07-27 | 1995-07-04 | Chiron Corporation | Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable |
US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
DK0550631T3 (da) * | 1990-09-25 | 1997-01-20 | Rhone Poulenc Rorer Int | Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi |
DK62592D0 (es) * | 1992-05-14 | 1992-05-14 | Novo Nordisk As | |
DK62692D0 (es) * | 1992-05-14 | 1992-05-14 | Novo Nordisk As | |
DK155292D0 (da) * | 1992-12-23 | 1992-12-23 | Novo Nordisk As | Kemiske forbindelser, deres fremstilling og anvendelse |
GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
US5589467A (en) * | 1993-09-17 | 1996-12-31 | Novo Nordisk A/S | 2,5',N6-trisubstituted adenosine derivatives |
US5683989A (en) * | 1993-12-17 | 1997-11-04 | Novo Nordisk A/S | Treatment of ischemias by administration of 2,N6 -substituted adenosines |
US6376472B1 (en) | 1996-07-08 | 2002-04-23 | Aventis Pharmaceuticals, Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
US6495528B1 (en) | 1998-06-23 | 2002-12-17 | Smithkline Beecham Corporation | 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives |
AR049384A1 (es) * | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2881164A (en) * | 1955-07-18 | 1959-04-07 | American Cyanamid Co | Ribofuranosyl derivatives of 6-aralkylamino and 6-heterocyclicalkylaminopurines |
DE1670077C3 (de) * | 1966-05-07 | 1975-04-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Adenosin-Derivate und Verfahren zu ihrer Herstellung |
NL128629C (es) * | 1966-05-07 | |||
DE1670235A1 (de) * | 1967-06-08 | 1971-01-28 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung von Adenosin-Derivaten |
SE329623B (es) * | 1967-06-08 | 1970-10-19 | C F Boehringer Soehne Gmbh | |
DE1670265A1 (de) * | 1967-08-25 | 1971-01-28 | Boehringer Mannheim Gmbh | 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung |
DE1913816A1 (de) * | 1969-03-19 | 1971-01-14 | Boehringer Mannheim Gmbh | N(6)-Alkyl-adenosinderivate und Verfahren zu ihrer Herstellung |
DE2007273A1 (de) * | 1970-02-18 | 1971-08-26 | Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof | N(6) Aralkyl adenosin Derivate und Verfahren zur Herstellung derselben |
US4224438A (en) * | 1970-07-14 | 1980-09-23 | Boehringer Mannheim Gmbh | Adenosine-5'-carboxylic acid amides |
DE2052596A1 (de) * | 1970-10-27 | 1972-05-04 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neuartige Verwendung von N(6)-substituierten Adenosin-Derivaten |
US4029884A (en) * | 1971-03-18 | 1977-06-14 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
DE2139107A1 (de) * | 1971-08-04 | 1973-02-15 | Merck Patent Gmbh | Heterocyclisch substituierte adenosinverbindungen |
BE788958A (fr) * | 1971-09-18 | 1973-03-19 | Schering Ag | Derives d'adenosine et leur procede de preparation |
US4090021A (en) * | 1971-10-08 | 1978-05-16 | Schering Aktiengesellschaft | Process for the production of N6 -substituted adenosine nucleotides and products resulting therefrom |
JPS4926295A (es) * | 1972-07-06 | 1974-03-08 | ||
DE2238923A1 (de) * | 1972-08-08 | 1974-02-14 | Boehringer Mannheim Gmbh | Acylierte n(6)-aralkyl-adenosinderivate und verfahren zur herstellung derselben |
US3966916A (en) * | 1972-09-09 | 1976-06-29 | Boehringer Mannheim G.M.B.H. | N(6)-disubstituted adenoisine compounds and therapeutic compositions |
JPS5022040A (es) * | 1973-06-27 | 1975-03-08 | ||
US4081534A (en) * | 1973-09-11 | 1978-03-28 | Burroughs Wellcome Co. | Amino purine nucleosides as autoimmune suppressant agents |
DE2426682A1 (de) * | 1974-06-01 | 1975-12-11 | Boehringer Mannheim Gmbh | Neue n(6)-disubstituierte adenosinderivate und verfahren zur herstellung derselben |
US4167565A (en) * | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
US4189485A (en) * | 1977-08-23 | 1980-02-19 | Takeda Chemical Industries, Ltd. | Purine derivatives |
JPS57130997A (en) * | 1981-01-30 | 1982-08-13 | Searle & Co | N6-substituted adenosine |
JPS57140716A (en) * | 1981-02-24 | 1982-08-31 | Yamasa Shoyu Co Ltd | Antiallergic agent |
US4514405A (en) * | 1981-09-17 | 1985-04-30 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Use of adenosine derivatives as anticonvulsants |
US4495180A (en) * | 1982-06-21 | 1985-01-22 | Merck & Co., Inc. | Prodrugs of Ara-A an antiviral agent |
CA1239397A (en) * | 1983-08-01 | 1988-07-19 | James A. Bristol | N.sup.6-substituted adenosines |
DE3406533A1 (de) * | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
AU579412B2 (en) * | 1984-10-26 | 1988-11-24 | Warner-Lambert Company | N` - substituted adenosines |
-
1985
- 1985-04-11 EP EP88106818A patent/EP0305643B1/en not_active Expired - Lifetime
- 1985-04-11 WO PCT/US1985/000633 patent/WO1985004882A1/en active IP Right Grant
- 1985-04-11 EP EP88106817A patent/EP0300145A3/en not_active Withdrawn
- 1985-04-11 AT AT85902253T patent/ATE50777T1/de active
- 1985-04-11 AU AU42195/85A patent/AU582359B2/en not_active Ceased
- 1985-04-11 EP EP85902253A patent/EP0180614B1/en not_active Expired - Lifetime
- 1985-04-11 JP JP60501780A patent/JPH0655756B2/ja not_active Expired - Lifetime
- 1985-04-11 DE DE88106818T patent/DE3587717T2/de not_active Expired - Fee Related
- 1985-04-11 DE DE8585902253T patent/DE3576344D1/de not_active Expired - Fee Related
- 1985-04-11 EP EP88106816A patent/EP0300144A3/en not_active Withdrawn
- 1985-04-12 ZA ZA852746A patent/ZA852746B/xx unknown
- 1985-04-16 IE IE96585A patent/IE60213B1/en not_active IP Right Cessation
- 1985-04-16 IE IE930270A patent/IE930270L/xx unknown
- 1985-04-16 ES ES542290A patent/ES8707544A1/es not_active Expired
- 1985-04-16 IE IE930269A patent/IE930269L/xx unknown
- 1985-12-04 CA CA000479012A patent/CA1279063C/en not_active Expired - Fee Related
-
1986
- 1986-02-13 US US06/829,285 patent/US5043325A/en not_active Expired - Fee Related
-
1988
- 1988-04-28 AT AT88106818T patent/ATE99695T1/de active
-
1990
- 1990-09-28 CA CA000615876A patent/CA1293721C/en not_active Expired - Fee Related
- 1990-09-28 CA CA000615877A patent/CA1293722C/en not_active Expired - Fee Related
- 1990-09-28 CA CA000615878A patent/CA1305135C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0300145A2 (en) | 1989-01-25 |
ZA852746B (en) | 1985-12-24 |
JPS61501914A (ja) | 1986-09-04 |
AU582359B2 (en) | 1989-03-23 |
DE3587717D1 (de) | 1994-02-17 |
EP0305643A3 (en) | 1989-08-30 |
IE60213B1 (en) | 1994-06-15 |
EP0180614B1 (en) | 1990-03-07 |
EP0305643B1 (en) | 1994-01-05 |
CA1279063C (en) | 1991-01-15 |
US5043325A (en) | 1991-08-27 |
CA1293721C (en) | 1991-12-31 |
ATE99695T1 (de) | 1994-01-15 |
ATE50777T1 (de) | 1990-03-15 |
AU4219585A (en) | 1985-11-15 |
EP0300144A3 (en) | 1989-09-27 |
JPH0655756B2 (ja) | 1994-07-27 |
CA1305135C (en) | 1992-07-14 |
EP0300145A3 (en) | 1989-08-30 |
WO1985004882A1 (en) | 1985-11-07 |
DE3587717T2 (de) | 1994-04-28 |
DE3576344D1 (de) | 1990-04-12 |
EP0305643A2 (en) | 1989-03-08 |
EP0300144A2 (en) | 1989-01-25 |
IE930269L (en) | 1985-10-18 |
ES8707544A1 (es) | 1987-08-01 |
IE850965L (en) | 1985-10-17 |
EP0180614A1 (en) | 1986-05-14 |
IE930270L (en) | 1985-10-18 |
CA1293722C (en) | 1991-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES542290A0 (es) | Un procedimiento para la preparacion de derivados de adenosina v-6 monosustituidos. | |
MY118612A (en) | Pyrazine compounds | |
LV10608A (lv) | N-acetonilbenzamidi un to pielietojums par fungicidiem | |
KR890700598A (ko) | 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도 | |
ATE82117T1 (de) | Topische zusammensetzung. | |
DK452687D0 (da) | Dihydropyridinforbindelser, isomere, isomerblandinger, optiske antipoder og racemater deraf, deres fremstilling og anvendelse som laegemidler | |
FR2576022B1 (fr) | Nouveaux derives de la pristinamycine ii b, leur preparation et les compositions pharmaceutiques qui les contiennent | |
DE68911371T2 (de) | 2,2-Disubstituierte Benzopyran-Leukotrien-D4-Antagonisten. | |
AU556932B2 (en) | Dipetide with heterocyclic groiup | |
ES539654A0 (es) | Un procedimiento para la preparacion de nuevos derivados de triazina | |
IL74556A (en) | Derivatives of 1,5-diaryl-1,2,4-thiadiazine 1-oxide,their preparation and pharmaceutical compositions containing them | |
ES2046181T3 (es) | Procedimiento de preparacion de derivados de cianoacetamida con actividad fungicida. | |
GR3001123T3 (en) | Antiarrhythmic agents | |
DK470888D0 (da) | Imidazobenzodiazepinderivater, deres fresmtilling samt laegemidler med indholdd deraf | |
ES8404370A1 (es) | Procedimiento para preparar fosfatos de oximas aciclicos y heterociclicos con actividad insecticida, acaricida y nematocida. | |
IL59424A (en) | 1,3,4-oxadiazolylmethylthiol phosphates,their manufacture and pesticidal compositions containing them | |
MX9304249A (es) | Derivados de n-acildihidroquinolina, metodo para su produccion y composiciones herbicidas que los contienen. | |
PT80161A (en) | A n-(6-substituted pyridine-2-carbonyl)-3-substituted histidine derivative a method of preparing the same and its use as an anti-tumor agent | |
ES2038672T3 (es) | Antagonistas h1 purinicos de la histamina, su preparacion y composiciones farmaceuticas que los contienen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19940228 |