ES525684A0 - Procedimiento para preparar derivados de prolina - Google Patents

Procedimiento para preparar derivados de prolina

Info

Publication number
ES525684A0
ES525684A0 ES525684A ES525684A ES525684A0 ES 525684 A0 ES525684 A0 ES 525684A0 ES 525684 A ES525684 A ES 525684A ES 525684 A ES525684 A ES 525684A ES 525684 A0 ES525684 A0 ES 525684A0
Authority
ES
Spain
Prior art keywords
amino
hydrogen
aryl
carbonyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES525684A
Other languages
English (en)
Other versions
ES8506271A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES8506271A1 publication Critical patent/ES8506271A1/es
Publication of ES525684A0 publication Critical patent/ES525684A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/80—Antihypertensive peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
ES525684A 1982-01-22 1983-09-16 Procedimiento para preparar derivados de prolina Granted ES525684A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8201832 1982-01-22

Publications (2)

Publication Number Publication Date
ES8506271A1 ES8506271A1 (es) 1985-07-01
ES525684A0 true ES525684A0 (es) 1985-07-01

Family

ID=10527812

Family Applications (2)

Application Number Title Priority Date Filing Date
ES525685A Granted ES525685A0 (es) 1982-01-22 1983-09-16 Procedimiento para preparar derivados de prolina
ES525684A Granted ES525684A0 (es) 1982-01-22 1983-09-16 Procedimiento para preparar derivados de prolina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES525685A Granted ES525685A0 (es) 1982-01-22 1983-09-16 Procedimiento para preparar derivados de prolina

Country Status (17)

Country Link
US (1) US4528282A (es)
EP (1) EP0084941B1 (es)
JP (1) JPS58134075A (es)
AT (1) ATE25850T1 (es)
AU (1) AU563149B2 (es)
DE (1) DE3370159D1 (es)
DK (1) DK23883A (es)
ES (2) ES525685A0 (es)
FI (1) FI830186L (es)
GR (1) GR77061B (es)
HU (1) HU189637B (es)
IE (1) IE54551B1 (es)
IL (1) IL67705A0 (es)
NO (1) NO830203L (es)
NZ (1) NZ203063A (es)
PT (1) PT76130A (es)
ZA (1) ZA83273B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61502818A (ja) * 1984-07-30 1986-12-04 シェリング・コ−ポレ−ション シス、エンド−オクタヒドロシクロペンタ〔ｂ〕ピロ−ル−２−カルボキシレ−トの新規製造方法
FR2573765B1 (fr) * 1984-11-23 1988-06-10 Solvay Procede pour la synthese de peptides
HU192914B (en) * 1985-02-11 1987-07-28 Richter Gedeon Vegyeszet Process for producing new 3-/substituted amino/-5-phenyl-2/3h/-furanone derivatives and pharmaceutically acceptable salts
ES2051702T3 (es) * 1986-04-01 1994-07-01 Wako Pure Chem Ind Ltd Derivados peptidicos y metodo para medir la actividad de sustancias fisiologicamente activas usandolos como sustratos.
AT395012B (de) * 1986-06-27 1992-08-25 Richter Gedeon Vegyeszet Verfahren zur herstellung von n-(1(s)|thoxycarbonyl-3-phenyl-propyl)-(s)-alanyl-(s)prolin und von dessen saeureadditionssalzen
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
ES2231879T3 (es) * 1996-08-16 2005-05-16 Warner-Lambert Company Llc Inhibidores de metaloproteinasas de la matriz de acido butirico.
JP2002531576A (ja) 1998-12-10 2002-09-24 エフ．ホフマン−ラ ロシュ アーゲー プロコラーゲンｃ−プロテイナーゼ阻害剤
PT1595866T (pt) * 2003-01-31 2016-09-14 Sanwa Kagaku Kenkyusho Co Cianopirrolidinas úteis para o tratamento entre outras de síndrome metabólica

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4303583A (en) * 1979-08-13 1981-12-01 American Home Products Corporation 1H,5H-[1,4]Thiazepino[4,3-a]indole-1,5-diones
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4350633A (en) * 1980-07-01 1982-09-21 American Home Products Corporation N-(2-Substituted-1-oxoalkyl)-2,3-dihydro-1H-indole-2-carboxylic acid derivatives
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
FR2492381A1 (fr) * 1980-10-21 1982-04-23 Science Union & Cie Nouveaux acides aza bicyclo alcane carboxyliques substitues leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
US4390700A (en) * 1980-11-10 1983-06-28 Ciba-Geigy Corporation 1-Carboxyazaalkanoyl-tetrahydroquinoline-2-carboxylic acids
US4425355A (en) * 1981-02-17 1984-01-10 Warner-Lambert Company Substituted acyl derivatives of chair form of octahydro-1H-indole-2-carboxylic acids
US4402969A (en) * 1981-03-23 1983-09-06 Merck & Co., Inc. Antihypertensive proline derivatives
US4374246A (en) * 1981-06-18 1983-02-15 Norwich Eaton Pharmaceuticals, Inc. 1-N-[(1-Carboxy-3-phenylpropyl)glycyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4370494A (en) * 1982-01-15 1983-01-25 Norwich Eaton Pharmaceuticals, Inc. Converting enzyme inhibitors

Also Published As

Publication number Publication date
GR77061B (es) 1984-09-05
ES8506272A1 (es) 1985-07-01
FI830186A0 (fi) 1983-01-20
IL67705A0 (en) 1983-05-15
ATE25850T1 (de) 1987-03-15
DK23883D0 (da) 1983-01-21
AU1034183A (en) 1983-07-28
DE3370159D1 (en) 1987-04-16
IE54551B1 (en) 1989-11-22
DK23883A (da) 1983-07-23
JPS58134075A (ja) 1983-08-10
AU563149B2 (en) 1987-07-02
ES525685A0 (es) 1985-07-01
FI830186L (fi) 1983-07-23
HU189637B (en) 1986-07-28
US4528282A (en) 1985-07-09
NZ203063A (en) 1985-12-13
EP0084941B1 (en) 1987-03-11
PT76130A (en) 1983-02-01
ES8506271A1 (es) 1985-07-01
IE830056L (en) 1983-07-22
EP0084941A1 (en) 1983-08-03
NO830203L (no) 1983-07-25
ZA83273B (en) 1983-10-26

Similar Documents

Publication Publication Date Title
IL117805A0 (en) Carbonyl piperazinyl and piperidinyl compounds
DK1265606T3 (da) Celleadhæsionsinhibitorer
KR950032114A (ko) 프롤린 아미드 유도체
PT928788E (pt) Compostos farmaceuticamente activos
ATE120955T1 (de) Benzyliden-malononitril-derivate zur hemmung von proliferativen prozessen in säugetierzellen.
HUT60271A (en) Process for producing tricyclic compounds, functioning as enzyme inhibitior and comprising amino or nitro group and pharmaceutical compositions comprising same as active ingredient
ES525685A0 (es) Procedimiento para preparar derivados de prolina
ES2053525T3 (es) Acidos hidroxamicos.
ATE150301T1 (de) Aminoalkanesulfonsäurederivate und pharmazeutische zusammensetzungen davon zur prävention oder behandlung von herzerkrankungen
KR880007461A (ko) 헤테로 사이클-치환 디포스포네이트화합물 및 이의 약제학적 조성물
AU1166988A (en) New peptide derivatives having a polycyclic nitrogenous structure, process for the preparation thereof and pharmaceutical compositions containing them
ES8505948A1 (es) Un derivado de amida.
ES8607332A1 (es) Procedimiento para preparar sales de derivados de oxazafos- forina
IT1241452B (it) Derivati oligopeptidici dell'ipoxantina dotati di attivita' immunomodulante e composizioni farmaceutiche che li contengono
EP0617009A4 (en) NEW AMINO ACID DERIVATIVE.
ES8307734A1 (es) "procedimiento de producir derivados amidicos".
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.