ES485104A1 - Procedimiento para preparar derivados de ciclosporina - Google Patents
Procedimiento para preparar derivados de ciclosporinaInfo
- Publication number
- ES485104A1 ES485104A1 ES485104A ES485104A ES485104A1 ES 485104 A1 ES485104 A1 ES 485104A1 ES 485104 A ES485104 A ES 485104A ES 485104 A ES485104 A ES 485104A ES 485104 A1 ES485104 A1 ES 485104A1
- Authority
- ES
- Spain
- Prior art keywords
- production
- cyclosporin
- pharmaceutical compositions
- compositions containing
- cyclosporin derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- ZMKGDQSIRSGUDJ-VSROPUKISA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-33-[(e,1r,2r)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 Chemical compound CCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-VSROPUKISA-N 0.000 abstract 4
- ZMKGDQSIRSGUDJ-UHFFFAOYSA-N NVa2 cyclosporine Natural products CCCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(C(C)C)NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O ZMKGDQSIRSGUDJ-UHFFFAOYSA-N 0.000 abstract 4
- 108010019249 cyclosporin G Proteins 0.000 abstract 4
- TYFOVYYNQGNDKH-KCLVVAEESA-N (3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-30-ethyl-33-[(1r)-1-hydroxy-2-methylhexyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26, Chemical compound CCCCC(C)[C@@H](O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](CC)NC1=O TYFOVYYNQGNDKH-KCLVVAEESA-N 0.000 abstract 1
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- 241001149964 Tolypocladium Species 0.000 abstract 1
- 229960001265 ciclosporin Drugs 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000050 nutritive effect Effects 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/885—Trichoderma
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1077678A CH637124A5 (en) | 1978-10-18 | 1978-10-18 | Antibiotic, its preparation and use |
| CH269679A CH639961A5 (en) | 1979-03-22 | 1979-03-22 | Dihydocyclosporin G, its preparation and use as a medicine |
| CH748079A CH642954A5 (en) | 1979-08-15 | 1979-08-15 | Isocyclosporin G, its preparation and medicaments containing it |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES485104A1 true ES485104A1 (es) | 1980-05-16 |
Family
ID=27173855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485104A Expired ES485104A1 (es) | 1978-10-18 | 1979-10-17 | Procedimiento para preparar derivados de ciclosporina |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4288431A (OSRAM) |
| AU (1) | AU530379B2 (OSRAM) |
| CA (1) | CA1129359A (OSRAM) |
| CY (1) | CY1286A (OSRAM) |
| DE (1) | DE2941080A1 (OSRAM) |
| DK (1) | DK148752C (OSRAM) |
| ES (1) | ES485104A1 (OSRAM) |
| FI (1) | FI60032C (OSRAM) |
| FR (1) | FR2439182A1 (OSRAM) |
| GB (1) | GB2033398B (OSRAM) |
| HK (1) | HK48685A (OSRAM) |
| IE (1) | IE49084B1 (OSRAM) |
| IL (1) | IL58465A (OSRAM) |
| IT (1) | IT1164109B (OSRAM) |
| KE (1) | KE3517A (OSRAM) |
| MY (1) | MY8500618A (OSRAM) |
| NL (1) | NL7907609A (OSRAM) |
| NZ (1) | NZ191865A (OSRAM) |
| PH (1) | PH14086A (OSRAM) |
| PT (1) | PT70324A (OSRAM) |
| SE (1) | SE448386B (OSRAM) |
| SG (1) | SG14685G (OSRAM) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2065273A1 (es) * | 1993-05-25 | 1995-02-01 | Biogal Gyogyszergyar | Procedimiento para la purificacion de ciclosporina a. |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4396542A (en) * | 1980-02-14 | 1983-08-02 | Sandoz Ltd. | Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production |
| AU548156B2 (en) * | 1980-02-14 | 1985-11-28 | Novartis Ag | Cyclo sporin |
| US4384996A (en) * | 1981-01-09 | 1983-05-24 | Sandoz Ltd. | Novel cyclosporins |
| EP0170623B1 (en) * | 1984-08-02 | 1990-11-28 | Sandoz Ag | Novel pharmaceutical use of (nva)2-cyclosporine |
| GB8422253D0 (en) * | 1984-09-04 | 1984-10-10 | Sandoz Ltd | Organic compounds |
| US4727035A (en) * | 1984-11-14 | 1988-02-23 | Mahoney Walter C | Immunoassay for cyclosporin |
| US4814323A (en) * | 1986-03-25 | 1989-03-21 | Andrieu J M | Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus |
| US5427960A (en) * | 1987-03-27 | 1995-06-27 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies |
| US5239057A (en) * | 1987-03-27 | 1993-08-24 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
| US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| DE3888357T2 (de) * | 1987-06-22 | 1994-09-15 | Merck & Co Inc | Cyclosporin-Derivate, die eine modifizierte Aminosäure auf Stellung 8 tragen. |
| GB8717300D0 (en) * | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
| US5227467A (en) * | 1987-08-03 | 1993-07-13 | Merck & Co., Inc. | Immunosuppressive fluorinated cyclosporin analogs |
| US4839342A (en) * | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
| DE3851152T2 (de) * | 1987-09-03 | 1995-01-26 | Univ Georgia | Cyclosporin-augenmittel. |
| US5236899A (en) * | 1987-11-16 | 1993-08-17 | Merck & Co., Inc. | 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance |
| US4914188A (en) * | 1987-11-16 | 1990-04-03 | Merck & Co., Inc. | Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin |
| HU201577B (en) * | 1988-12-20 | 1990-11-28 | Gyogyszerkutato Intezet | Process for producing cyclosporin antibiotics |
| US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
| US5540931A (en) * | 1989-03-03 | 1996-07-30 | Charles W. Hewitt | Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants |
| FR2649120B1 (fr) * | 1989-06-30 | 1994-01-28 | Cayla | Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede |
| GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| ATE127528T1 (de) * | 1991-04-06 | 1995-09-15 | Dresden Arzneimittel | Verfahren zur fermentativen herstellung und isolierung von cyclosporin a sowie neue cyclosporin- bildende stämme. |
| EP0668774A1 (en) * | 1991-05-03 | 1995-08-30 | Seragen, Inc. | Interleukin receptor targeted molecules for treatment of inflammatory arthritis |
| GB9203886D0 (en) * | 1992-02-24 | 1992-04-08 | Sandoz Ltd | Improvements in or relating to organic compounds |
| DE19611094C2 (de) | 1996-03-21 | 1999-06-17 | Dresden Arzneimittel | Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens |
| US5747330A (en) * | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
| JP4261049B2 (ja) | 1997-10-08 | 2009-04-30 | アイソテクニカ インコーポレイテッド | 重水素化シクロスポリンアナログおよび免疫調節剤としてのそれらの使用 |
| US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| ES2255275T3 (es) | 1998-07-01 | 2006-06-16 | Debiopharm S.A. | Nueva ciclosporina con perfil de actividad mejorado. |
| US7176001B1 (en) * | 2000-02-29 | 2007-02-13 | Biocon Limited | Manufacture and purification of cyclosporin A |
| US7033604B2 (en) | 2001-07-06 | 2006-04-25 | Sucampo Ag | Composition for topical administration |
| CN100334106C (zh) * | 2001-10-19 | 2007-08-29 | 伊索泰克尼卡股份有限公司 | 环孢菌素类似物的合成 |
| EP1458405A1 (en) * | 2001-11-21 | 2004-09-22 | Sucampo AG | Use of fk506 and analogues for treating allergic diseases |
| CA2518265A1 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
| JP2008514701A (ja) * | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキン類似体およびそれらの薬学的使用 |
| WO2006041631A2 (en) * | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| WO2008036244A1 (en) * | 2006-09-18 | 2008-03-27 | The Burham Institute For Medical Research | Use of cyclosporin a to sensitize resistant cancer cells to death receptor ligands |
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| EP2391376A4 (en) * | 2009-01-30 | 2012-08-01 | Enanta Pharm Inc | ANALOGUES OF CYCLOSPORIN FOR PREVENTING OR TREATING HEPATITIS C INFECTION |
| US8481483B2 (en) * | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8367053B2 (en) * | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8349312B2 (en) * | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| US8685917B2 (en) * | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8623814B2 (en) * | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
| CN107496902B (zh) | 2010-12-15 | 2022-01-18 | 康卓维尔制药公司 | 在氨基酸1和3位修改的环孢菌素类似分子 |
| WO2012145426A1 (en) | 2011-04-18 | 2012-10-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat cancer using cyclosporine and cyclosporine derivatives |
| EP2705856A1 (en) | 2012-09-07 | 2014-03-12 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. | Compounds for the treatment of neurodegenerative disorders |
| US8906853B2 (en) | 2012-11-28 | 2014-12-09 | Enanta Pharmaceuticals, Inc. | [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection |
| MX2016002458A (es) | 2013-08-26 | 2016-08-08 | Enanta Pharm Inc | Análogos novedosos de ciclosporina para prevenir o tratar la infección por hepatitis c. |
| US9669095B2 (en) | 2014-11-03 | 2017-06-06 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
| WO2016112321A1 (en) * | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2455859C2 (de) * | 1973-12-06 | 1983-12-15 | Sandoz-Patent-GmbH, 7850 Lörrach | Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung |
| CH614931A5 (OSRAM) * | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
-
1979
- 1979-10-09 SE SE7908350A patent/SE448386B/sv not_active IP Right Cessation
- 1979-10-10 DE DE19792941080 patent/DE2941080A1/de active Granted
- 1979-10-10 DK DK428179A patent/DK148752C/da not_active IP Right Cessation
- 1979-10-10 FI FI793142A patent/FI60032C/fi not_active IP Right Cessation
- 1979-10-12 US US06/084,100 patent/US4288431A/en not_active Expired - Lifetime
- 1979-10-15 GB GB7935689A patent/GB2033398B/en not_active Expired
- 1979-10-15 CY CY1286A patent/CY1286A/en unknown
- 1979-10-15 NL NL7907609A patent/NL7907609A/nl not_active Application Discontinuation
- 1979-10-16 IT IT7950577A patent/IT1164109B/it active
- 1979-10-16 NZ NZ191865A patent/NZ191865A/en unknown
- 1979-10-16 PT PT70324A patent/PT70324A/pt not_active IP Right Cessation
- 1979-10-16 IL IL7958465A patent/IL58465A/xx unknown
- 1979-10-16 IE IE1967/79A patent/IE49084B1/en not_active IP Right Cessation
- 1979-10-17 CA CA337,826A patent/CA1129359A/en not_active Expired
- 1979-10-17 FR FR7925780A patent/FR2439182A1/fr active Granted
- 1979-10-17 ES ES485104A patent/ES485104A1/es not_active Expired
- 1979-10-17 PH PH23188A patent/PH14086A/en unknown
- 1979-10-18 AU AU51911/79A patent/AU530379B2/en not_active Ceased
-
1985
- 1985-02-27 SG SG146/85A patent/SG14685G/en unknown
- 1985-03-22 KE KE3517A patent/KE3517A/xx unknown
- 1985-06-20 HK HK486/85A patent/HK48685A/xx not_active IP Right Cessation
- 1985-12-30 MY MY618/85A patent/MY8500618A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2065273A1 (es) * | 1993-05-25 | 1995-02-01 | Biogal Gyogyszergyar | Procedimiento para la purificacion de ciclosporina a. |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2033398B (en) | 1982-09-08 |
| IT7950577A0 (it) | 1979-10-16 |
| FI793142A7 (fi) | 1980-04-19 |
| CY1286A (en) | 1985-07-05 |
| AU530379B2 (en) | 1983-07-14 |
| FR2439182B1 (OSRAM) | 1984-02-10 |
| IL58465A (en) | 1982-04-30 |
| FI60032B (fi) | 1981-07-31 |
| GB2033398A (en) | 1980-05-21 |
| IE791967L (en) | 1980-04-18 |
| PT70324A (fr) | 1979-11-01 |
| FI60032C (fi) | 1981-11-10 |
| IT1164109B (it) | 1987-04-08 |
| SE448386B (sv) | 1987-02-16 |
| NZ191865A (en) | 1984-05-31 |
| IL58465A0 (en) | 1980-01-31 |
| DE2941080C2 (OSRAM) | 1990-03-29 |
| DK428179A (da) | 1980-04-19 |
| US4288431A (en) | 1981-09-08 |
| SE7908350L (sv) | 1980-04-19 |
| IE49084B1 (en) | 1985-07-24 |
| DK148752B (da) | 1985-09-16 |
| DK148752C (da) | 1986-02-10 |
| AU5191179A (en) | 1980-04-24 |
| KE3517A (en) | 1985-04-19 |
| NL7907609A (nl) | 1980-04-22 |
| CA1129359A (en) | 1982-08-10 |
| HK48685A (en) | 1985-06-28 |
| SG14685G (en) | 1985-08-16 |
| MY8500618A (en) | 1985-12-31 |
| DE2941080A1 (de) | 1980-05-08 |
| PH14086A (en) | 1981-02-10 |
| FR2439182A1 (fr) | 1980-05-16 |
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Effective date: 20000201 |