ES483898A1 - Procedimiento para la preparacion de aminoalcohilguanidinas sustituidas - Google Patents
Procedimiento para la preparacion de aminoalcohilguanidinas sustituidasInfo
- Publication number
- ES483898A1 ES483898A1 ES483898A ES483898A ES483898A1 ES 483898 A1 ES483898 A1 ES 483898A1 ES 483898 A ES483898 A ES 483898A ES 483898 A ES483898 A ES 483898A ES 483898 A1 ES483898 A1 ES 483898A1
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- methylindolyl
- indolyl
- substituted aminoalkyl
- disclosed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Abstract
Procedimiento para la preparación de aminoalcohilguanidinas sustituidas de la fórmula-01: **(Formula-01)** en que Alk es un grupo alcohileno C2-C5, eventualmente sustituido con un grupo hidroxi, y Ar significa un radical fenilo, naftilo, tetrahidronaftilo, indanilo o indenilo, no sustituido o sustituido con grupos alcohilo C1-C6, grupos alquenilo C2-C6, grupos alquinilo C2-C6, grupos alquenoxi C2- C6, radicales fenilo, átomos de halógeno, grupos amino, grupos acilo C2-C6 alifáticos, grupos amino-carbonilo, grupos ureido, grupos acilamino C1-C6 alifáticos, grupos cicloalcohilo C3-C8, o con grupos cicloalquenilo C4-C8, o significa un radical heterocíclico, monocíclico o bicíclico o bien tricíclico condensado, que eventualmente está sustituido como se ha indicado antes, constando el radical heterocíclico en cada caso de anillos que tienen cada uno 5 a 6 miembros, y pudiendo contener 1 a 4 heteroátomos, y sus sales, caracterizado porque se hace reaccionar una amina de la fórmula-02 (II): **(Fórmula-02)** en que Ar y Alk tienen los significados indicados, con un compuesto de la fórmula-03 (III): ***(Fórmula-03)** en que E es un grupo amino, que también puede contener un grupo protector de acilo, o significa un grupo alcohilmercapto C1-C6 o un grupo alcoxi C1-C6, o conjuntamente con NH2 puede también formar el grupo =NH.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7835819 | 1978-09-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES483898A1 true ES483898A1 (es) | 1980-09-01 |
Family
ID=10499477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES483898A Expired ES483898A1 (es) | 1978-09-06 | 1979-09-05 | Procedimiento para la preparacion de aminoalcohilguanidinas sustituidas |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4317832A (es) |
| JP (1) | JPS5547647A (es) |
| AR (1) | AR226825A1 (es) |
| AU (1) | AU525255B2 (es) |
| BE (1) | BE878577A (es) |
| CA (1) | CA1116173A (es) |
| CS (1) | CS210699B2 (es) |
| DE (1) | DE2935062A1 (es) |
| DK (1) | DK371679A (es) |
| ES (1) | ES483898A1 (es) |
| FI (1) | FI792755A (es) |
| FR (1) | FR2435465A1 (es) |
| GB (1) | GB2032425B (es) |
| GR (1) | GR70233B (es) |
| HU (1) | HU180716B (es) |
| IT (1) | IT1206985B (es) |
| NL (1) | NL7906656A (es) |
| NO (1) | NO146634C (es) |
| PL (1) | PL120349B1 (es) |
| RO (1) | RO76053A (es) |
| SE (1) | SE7907398L (es) |
| ZA (1) | ZA794662B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3426419A1 (de) * | 1984-07-18 | 1986-01-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue oxindol-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| TW250477B (es) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
| DE4318756A1 (de) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19956786A1 (de) * | 1999-11-25 | 2001-05-31 | Basf Ag | Verfahren zur Herstellung optisch aktiver Amine |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR778027A (fr) | 1933-07-12 | 1935-03-07 | Interrupteur automatique pour empêcher le vol de l'énergie électrique | |
| DE1168431B (de) * | 1960-10-13 | 1964-04-23 | Karl Ziegler Dr | Verfahren zur Herstellung von komplexen Aluminiumalkylverbindungen |
| US3501497A (en) * | 1964-02-19 | 1970-03-17 | Sterling Drug Inc | (1-indolinyl)-lower alkylamidoximes and -amidine |
| US3471515A (en) * | 1965-02-01 | 1969-10-07 | Sandoz Ag | (2-hydroxy-3-substituted aminopropoxy)indoles |
| GB1164828A (en) * | 1965-10-23 | 1969-09-24 | Robins Co Inc A H | 3-(2-Substituted Ethyl)Indoles and their Manufacture and Use |
| GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
| US3542873A (en) * | 1967-06-02 | 1970-11-24 | Dow Chemical Co | (2-hydroxy-3-(polychlorophenoxy)propyl)amine compounds |
| BE791013A (fr) * | 1971-11-08 | 1973-05-07 | Degussa | Aminoalkyl-guanidines substituees |
| JPS523384B2 (es) * | 1971-11-11 | 1977-01-27 | ||
| GB1527543A (en) * | 1976-04-15 | 1978-10-04 | Degussa | Basically substituted xanthine derivatives |
| WO1980000152A1 (en) * | 1978-07-03 | 1980-02-07 | Sandoz Ag | 3-aminopropoxy-aryl derivates,preparation and use thereof |
-
1979
- 1979-08-30 DE DE19792935062 patent/DE2935062A1/de not_active Withdrawn
- 1979-08-31 AR AR277926A patent/AR226825A1/es active
- 1979-09-03 BE BE6/46933A patent/BE878577A/fr unknown
- 1979-09-04 ZA ZA00794662A patent/ZA794662B/xx unknown
- 1979-09-04 IT IT7950162A patent/IT1206985B/it active
- 1979-09-04 FR FR7922054A patent/FR2435465A1/fr not_active Withdrawn
- 1979-09-04 GB GB7930586A patent/GB2032425B/en not_active Expired
- 1979-09-05 PL PL1979218136A patent/PL120349B1/pl unknown
- 1979-09-05 CS CS796019A patent/CS210699B2/cs unknown
- 1979-09-05 CA CA335,022A patent/CA1116173A/en not_active Expired
- 1979-09-05 FI FI792755A patent/FI792755A/fi not_active Application Discontinuation
- 1979-09-05 HU HU79DE1009A patent/HU180716B/hu unknown
- 1979-09-05 NO NO792874A patent/NO146634C/no unknown
- 1979-09-05 DK DK371679A patent/DK371679A/da unknown
- 1979-09-05 GR GR59974A patent/GR70233B/el unknown
- 1979-09-05 ES ES483898A patent/ES483898A1/es not_active Expired
- 1979-09-05 AU AU50608/79A patent/AU525255B2/en not_active Ceased
- 1979-09-05 NL NL7906656A patent/NL7906656A/xx not_active Application Discontinuation
- 1979-09-05 SE SE7907398A patent/SE7907398L/xx not_active Application Discontinuation
- 1979-09-05 US US06/072,777 patent/US4317832A/en not_active Expired - Lifetime
- 1979-09-06 RO RO7998517A patent/RO76053A/ro unknown
- 1979-09-06 JP JP11360079A patent/JPS5547647A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA794662B (en) | 1980-08-27 |
| PL120349B1 (en) | 1982-02-27 |
| GR70233B (es) | 1982-09-01 |
| HU180716B (en) | 1983-04-29 |
| IT1206985B (it) | 1989-05-17 |
| PL218136A1 (es) | 1980-08-25 |
| NO146634B (no) | 1982-08-02 |
| NO146634C (no) | 1982-11-10 |
| AU525255B2 (en) | 1982-10-28 |
| FI792755A (fi) | 1980-03-07 |
| BE878577A (fr) | 1980-03-03 |
| NO792874L (no) | 1980-03-07 |
| IT7950162A0 (it) | 1979-09-04 |
| AU5060879A (en) | 1980-03-13 |
| RO76053A (ro) | 1981-11-04 |
| CS210699B2 (en) | 1982-01-29 |
| DK371679A (da) | 1980-03-07 |
| SE7907398L (sv) | 1980-03-07 |
| CA1116173A (en) | 1982-01-12 |
| GB2032425B (en) | 1982-10-13 |
| GB2032425A (en) | 1980-05-08 |
| FR2435465A1 (fr) | 1980-04-04 |
| US4317832A (en) | 1982-03-02 |
| DE2935062A1 (de) | 1980-03-20 |
| JPS5547647A (en) | 1980-04-04 |
| NL7906656A (nl) | 1980-03-10 |
| AR226825A1 (es) | 1982-08-31 |
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