ES479867A1 - Phenylether compound and its manufacture - Google Patents
Phenylether compound and its manufactureInfo
- Publication number
- ES479867A1 ES479867A1 ES479867A ES479867A ES479867A1 ES 479867 A1 ES479867 A1 ES 479867A1 ES 479867 A ES479867 A ES 479867A ES 479867 A ES479867 A ES 479867A ES 479867 A1 ES479867 A1 ES 479867A1
- Authority
- ES
- Spain
- Prior art keywords
- opt
- substd
- prepd
- give
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Propane derivs. of formula (I) are new. In (I) A is acyloxy or alkylsulphonyloxy (opt. substd. by >=1 halo), arylsulphonyloxy (opt. substd. by >=1 alkyl) or N3. Prepn. of (I), and analogues with A=OH or NH2 (or its acid addition salts) comprises first reaction of 2,6-dimethylphenol (IIe with propylene oxide in alkaline medium to give (IA=OH). This may them be acrylated and the prod. reacted with alkali metal azide to give (IA=N3) which is opt. reduced to (IA=NH2). (I), and cpd. with A=OH, are useful as antiarrhythmics and sedatives, (IA=NH2) is a known antiamythmic (without sedative activity). (I) are easily and simply prepd. from readily available materials without need for toxic reagents or special apparatus. They are prepd. in stable, pure form and (IA=N3) is converted almost quantitatively to (IA=NH2) of high purity at room temp. and pressure.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU78GO1401A HU176102B (en) | 1978-04-28 | 1978-04-28 | Process for preparing phenylethers |
Publications (1)
Publication Number | Publication Date |
---|---|
ES479867A1 true ES479867A1 (en) | 1980-08-16 |
Family
ID=10996855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479867A Expired ES479867A1 (en) | 1978-04-28 | 1979-04-24 | Phenylether compound and its manufacture |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPS5547641A (en) |
AT (1) | AT365169B (en) |
CA (1) | CA1132598A (en) |
CS (1) | CS208498B2 (en) |
DD (1) | DD143249A1 (en) |
DE (1) | DE2917178A1 (en) |
DK (1) | DK166820B1 (en) |
ES (1) | ES479867A1 (en) |
FI (1) | FI791340A (en) |
HU (1) | HU176102B (en) |
IL (1) | IL57080A (en) |
IN (1) | IN150039B (en) |
NO (1) | NO148450C (en) |
PL (3) | PL125109B1 (en) |
SU (3) | SU980614A3 (en) |
YU (1) | YU41861B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5932685A (en) * | 1982-08-16 | 1984-02-22 | Hitachi Constr Mach Co Ltd | Capacity controller for variable capacity pump |
JPS60146713U (en) * | 1984-03-09 | 1985-09-28 | 株式会社 名機製作所 | Injection molding machine with hydraulic oil heating circuit |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1643240A1 (en) * | 1966-09-16 | 1971-06-24 | Boehringer Sohn Ingelheim | Process for the preparation of new racemic or optically active 1-phenoxy-2-aminoalkanes |
-
1978
- 1978-04-28 HU HU78GO1401A patent/HU176102B/en unknown
-
1979
- 1979-04-16 IL IL57080A patent/IL57080A/en unknown
- 1979-04-16 IN IN368/CAL/79A patent/IN150039B/en unknown
- 1979-04-24 CS CS792855A patent/CS208498B2/en unknown
- 1979-04-24 ES ES479867A patent/ES479867A1/en not_active Expired
- 1979-04-25 YU YU996/79A patent/YU41861B/en unknown
- 1979-04-25 FI FI791340A patent/FI791340A/en not_active Application Discontinuation
- 1979-04-26 PL PL1979225752A patent/PL125109B1/en unknown
- 1979-04-26 SU SU792760454A patent/SU980614A3/en active
- 1979-04-26 DK DK172679A patent/DK166820B1/en active IP Right Grant
- 1979-04-26 PL PL1979225751A patent/PL126968B1/en unknown
- 1979-04-26 PL PL21518179A patent/PL215181A1/xx unknown
- 1979-04-26 DD DD79212518A patent/DD143249A1/en unknown
- 1979-04-26 AT AT0312379A patent/AT365169B/en not_active IP Right Cessation
- 1979-04-27 NO NO791412A patent/NO148450C/en unknown
- 1979-04-27 DE DE19792917178 patent/DE2917178A1/en active Granted
- 1979-04-27 JP JP5157979A patent/JPS5547641A/en active Granted
- 1979-04-27 CA CA326,489A patent/CA1132598A/en not_active Expired
-
1980
- 1980-05-23 SU SU802925098A patent/SU978724A3/en active
- 1980-05-23 SU SU802925097A patent/SU980616A3/en active
Also Published As
Publication number | Publication date |
---|---|
ATA312379A (en) | 1981-05-15 |
IL57080A0 (en) | 1979-07-25 |
JPS5547641A (en) | 1980-04-04 |
DD143249A1 (en) | 1980-08-13 |
YU41861B (en) | 1988-02-29 |
SU980614A3 (en) | 1982-12-07 |
PL126968B1 (en) | 1983-09-30 |
DE2917178C2 (en) | 1989-01-12 |
DK166820B1 (en) | 1993-07-19 |
DK172679A (en) | 1979-10-29 |
YU99679A (en) | 1982-10-31 |
IL57080A (en) | 1983-05-15 |
SU980616A3 (en) | 1982-12-07 |
FI791340A (en) | 1979-10-29 |
SU978724A3 (en) | 1982-11-30 |
JPS6338979B2 (en) | 1988-08-03 |
IN150039B (en) | 1982-07-03 |
DE2917178A1 (en) | 1979-11-08 |
AT365169B (en) | 1981-12-28 |
NO148450C (en) | 1983-10-12 |
PL125109B1 (en) | 1983-03-31 |
CA1132598A (en) | 1982-09-28 |
HU176102B (en) | 1980-12-28 |
PL215181A1 (en) | 1980-01-28 |
NO791412L (en) | 1979-10-30 |
NO148450B (en) | 1983-07-04 |
CS208498B2 (en) | 1981-09-15 |
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