ES479867A1 - Phenylether compound and its manufacture - Google Patents

Phenylether compound and its manufacture

Info

Publication number
ES479867A1
ES479867A1 ES479867A ES479867A ES479867A1 ES 479867 A1 ES479867 A1 ES 479867A1 ES 479867 A ES479867 A ES 479867A ES 479867 A ES479867 A ES 479867A ES 479867 A1 ES479867 A1 ES 479867A1
Authority
ES
Spain
Prior art keywords
opt
substd
prepd
give
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479867A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkaloida Chemical Co Zrt
Original Assignee
Alkaloida Chemical Co Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkaloida Chemical Co Zrt filed Critical Alkaloida Chemical Co Zrt
Publication of ES479867A1 publication Critical patent/ES479867A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00Compounds containing azido groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/72Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Propane derivs. of formula (I) are new. In (I) A is acyloxy or alkylsulphonyloxy (opt. substd. by >=1 halo), arylsulphonyloxy (opt. substd. by >=1 alkyl) or N3. Prepn. of (I), and analogues with A=OH or NH2 (or its acid addition salts) comprises first reaction of 2,6-dimethylphenol (IIe with propylene oxide in alkaline medium to give (IA=OH). This may them be acrylated and the prod. reacted with alkali metal azide to give (IA=N3) which is opt. reduced to (IA=NH2). (I), and cpd. with A=OH, are useful as antiarrhythmics and sedatives, (IA=NH2) is a known antiamythmic (without sedative activity). (I) are easily and simply prepd. from readily available materials without need for toxic reagents or special apparatus. They are prepd. in stable, pure form and (IA=N3) is converted almost quantitatively to (IA=NH2) of high purity at room temp. and pressure.
ES479867A 1978-04-28 1979-04-24 Phenylether compound and its manufacture Expired ES479867A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78GO1401A HU176102B (en) 1978-04-28 1978-04-28 Process for preparing phenylethers

Publications (1)

Publication Number Publication Date
ES479867A1 true ES479867A1 (en) 1980-08-16

Family

ID=10996855

Family Applications (1)

Application Number Title Priority Date Filing Date
ES479867A Expired ES479867A1 (en) 1978-04-28 1979-04-24 Phenylether compound and its manufacture

Country Status (16)

Country Link
JP (1) JPS5547641A (en)
AT (1) AT365169B (en)
CA (1) CA1132598A (en)
CS (1) CS208498B2 (en)
DD (1) DD143249A1 (en)
DE (1) DE2917178A1 (en)
DK (1) DK166820B1 (en)
ES (1) ES479867A1 (en)
FI (1) FI791340A (en)
HU (1) HU176102B (en)
IL (1) IL57080A (en)
IN (1) IN150039B (en)
NO (1) NO148450C (en)
PL (3) PL125109B1 (en)
SU (3) SU980614A3 (en)
YU (1) YU41861B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5932685A (en) * 1982-08-16 1984-02-22 Hitachi Constr Mach Co Ltd Capacity controller for variable capacity pump
JPS60146713U (en) * 1984-03-09 1985-09-28 株式会社 名機製作所 Injection molding machine with hydraulic oil heating circuit

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1643240A1 (en) * 1966-09-16 1971-06-24 Boehringer Sohn Ingelheim Process for the preparation of new racemic or optically active 1-phenoxy-2-aminoalkanes

Also Published As

Publication number Publication date
ATA312379A (en) 1981-05-15
IL57080A0 (en) 1979-07-25
JPS5547641A (en) 1980-04-04
DD143249A1 (en) 1980-08-13
YU41861B (en) 1988-02-29
SU980614A3 (en) 1982-12-07
PL126968B1 (en) 1983-09-30
DE2917178C2 (en) 1989-01-12
DK166820B1 (en) 1993-07-19
DK172679A (en) 1979-10-29
YU99679A (en) 1982-10-31
IL57080A (en) 1983-05-15
SU980616A3 (en) 1982-12-07
FI791340A (en) 1979-10-29
SU978724A3 (en) 1982-11-30
JPS6338979B2 (en) 1988-08-03
IN150039B (en) 1982-07-03
DE2917178A1 (en) 1979-11-08
AT365169B (en) 1981-12-28
NO148450C (en) 1983-10-12
PL125109B1 (en) 1983-03-31
CA1132598A (en) 1982-09-28
HU176102B (en) 1980-12-28
PL215181A1 (en) 1980-01-28
NO791412L (en) 1979-10-30
NO148450B (en) 1983-07-04
CS208498B2 (en) 1981-09-15

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