ES472430A1 - Procedimiento para purificar heparina. - Google Patents
Procedimiento para purificar heparina.Info
- Publication number
- ES472430A1 ES472430A1 ES472430A ES472430A ES472430A1 ES 472430 A1 ES472430 A1 ES 472430A1 ES 472430 A ES472430 A ES 472430A ES 472430 A ES472430 A ES 472430A ES 472430 A1 ES472430 A1 ES 472430A1
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- oxalates
- freed
- mineral salts
- ppm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 6
- 229960002897 heparin Drugs 0.000 title abstract 6
- 229920000669 heparin Polymers 0.000 title abstract 6
- 229910052500 inorganic mineral Inorganic materials 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000011707 mineral Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 150000003891 oxalate salts Chemical class 0.000 title 1
- -1 oxalates Chemical class 0.000 title 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33170/77A GB1602439A (en) | 1977-08-08 | 1977-08-08 | Purified heparin |
| GB5204777 | 1977-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES472430A1 true ES472430A1 (es) | 1979-03-16 |
Family
ID=26261753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES472430A Expired ES472430A1 (es) | 1977-08-08 | 1978-08-08 | Procedimiento para purificar heparina. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4652555A (en, 2012) |
| JP (1) | JPS5446809A (en, 2012) |
| AT (1) | AT371713B (en, 2012) |
| AU (1) | AU529432B2 (en, 2012) |
| CA (1) | CA1105453A (en, 2012) |
| CH (1) | CH636888A5 (en, 2012) |
| DE (1) | DE2834702A1 (en, 2012) |
| DK (1) | DK350078A (en, 2012) |
| ES (1) | ES472430A1 (en, 2012) |
| FR (1) | FR2400036A1 (en, 2012) |
| IE (1) | IE47169B1 (en, 2012) |
| IT (1) | IT1192564B (en, 2012) |
| NL (1) | NL7808292A (en, 2012) |
| SE (1) | SE447872B (en, 2012) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2461719A2 (fr) * | 1979-07-20 | 1981-02-06 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
| EP0245813B2 (en) * | 1986-05-16 | 2000-03-22 | ITALFARMACO S.p.A. | EDTA-free heparins, heparin fractions and fragments, processes for their preparation and pharmaceutical compositions containing them |
| AR243204A1 (es) * | 1986-11-21 | 1993-07-30 | Ajorca Sa | Un metodo para la depolimerizacion quimica de polisacaridos. |
| SE8702254D0 (sv) * | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
| USRE38743E1 (en) | 1990-06-26 | 2005-06-14 | Aventis Pharma S.A. | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
| JP2001231595A (ja) * | 1999-12-15 | 2001-08-28 | Fuaruko Bio Syst:Kk | 特異的破骨細胞由来酸性ホスファターゼの測定方法 |
| JP4828795B2 (ja) | 2002-03-11 | 2011-11-30 | モメンタ ファーマシューティカルズ インコーポレイテッド | 硫酸化多糖類の分析 |
| US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
| AU2009250803A1 (en) * | 2008-05-20 | 2009-11-26 | Crystal Clear Partnership | Separation of polysaccharides by charge density gradient |
| ES2340902B1 (es) * | 2008-07-01 | 2011-05-03 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas. |
| US8435795B2 (en) * | 2010-01-19 | 2013-05-07 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
| DK2617737T3 (en) * | 2010-09-14 | 2017-04-03 | Univ Miyazaki | HIGH PURPOSE HEPARIN AND PREPARATION PROCEDURE |
| WO2012115952A1 (en) | 2011-02-21 | 2012-08-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3135660A (en) * | 1956-11-09 | 1964-06-02 | Riker Laboratories Inc | Method for purifying sulfated carbohydrates with oxidizing agents |
| US3482014A (en) * | 1966-06-29 | 1969-12-02 | Canada Packers Ltd | Orally active heparin and method for making and using same |
| FR2225406A1 (en) * | 1973-04-13 | 1974-11-08 | Choay Sa | Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects |
| CA1042001A (en) * | 1973-04-13 | 1978-11-07 | Choay S.A. | Mixed heparin salts |
-
1978
- 1978-08-08 JP JP9659278A patent/JPS5446809A/ja active Granted
- 1978-08-08 IE IE1616/78A patent/IE47169B1/en not_active IP Right Cessation
- 1978-08-08 ES ES472430A patent/ES472430A1/es not_active Expired
- 1978-08-08 NL NL787808292A patent/NL7808292A/xx not_active Application Discontinuation
- 1978-08-08 AU AU38748/78A patent/AU529432B2/en not_active Expired
- 1978-08-08 IT IT26580/78A patent/IT1192564B/it active
- 1978-08-08 CH CH841878A patent/CH636888A5/fr not_active IP Right Cessation
- 1978-08-08 SE SE7808487A patent/SE447872B/sv not_active IP Right Cessation
- 1978-08-08 DK DK350078A patent/DK350078A/da not_active Application Discontinuation
- 1978-08-08 CA CA308,923A patent/CA1105453A/en not_active Expired
- 1978-08-08 FR FR7823396A patent/FR2400036A1/fr active Granted
- 1978-08-08 AT AT0577078A patent/AT371713B/de not_active IP Right Cessation
- 1978-08-08 DE DE19782834702 patent/DE2834702A1/de active Granted
-
1982
- 1982-12-22 US US06/452,197 patent/US4652555A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AT371713B (de) | 1983-07-25 |
| CH636888A5 (fr) | 1983-06-30 |
| FR2400036A1 (fr) | 1979-03-09 |
| DK350078A (da) | 1979-02-09 |
| NL7808292A (nl) | 1979-02-12 |
| ATA577078A (de) | 1982-12-15 |
| JPS6129327B2 (en, 2012) | 1986-07-05 |
| JPS5446809A (en) | 1979-04-13 |
| DE2834702A1 (de) | 1979-02-22 |
| SE447872B (sv) | 1986-12-22 |
| DE2834702C2 (en, 2012) | 1988-11-10 |
| IE47169B1 (en) | 1984-01-11 |
| AU529432B2 (en) | 1983-06-09 |
| FR2400036B1 (en, 2012) | 1980-09-19 |
| AU3874878A (en) | 1980-02-14 |
| CA1105453A (en) | 1981-07-21 |
| IT1192564B (it) | 1988-04-20 |
| IE781616L (en) | 1979-02-08 |
| US4652555A (en) | 1987-03-24 |
| SE7808487L (sv) | 1979-02-09 |
| IT7826580A0 (it) | 1978-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980302 |