ZA756660B - Oil-free adjuvant composition,containing n-acetyl-muramyl-l-alanyl-d-glutamatic acid as an active principle - Google Patents

Oil-free adjuvant composition,containing n-acetyl-muramyl-l-alanyl-d-glutamatic acid as an active principle

Info

Publication number
ZA756660B
ZA756660B ZA756660A ZA756660A ZA756660B ZA 756660 B ZA756660 B ZA 756660B ZA 756660 A ZA756660 A ZA 756660A ZA 756660 A ZA756660 A ZA 756660A ZA 756660 B ZA756660 B ZA 756660B
Authority
ZA
South Africa
Prior art keywords
muramyl
alanyl
acetyl
oil
active principle
Prior art date
Application number
ZA756660A
Inventor
Francoise Audibert
Audibert Francoise
Louis Chedid
Chedid Louis
Pierre Lefrancier
Lefrancier Pierre
Jean Choay
Choay Jean
Edgar Lederer
Lederer Edgar
Original Assignee
Anvar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/516,991 external-priority patent/US4186194A/en
Application filed by Anvar filed Critical Anvar
Publication of ZA756660B publication Critical patent/ZA756660B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/5555—Muramyl dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ZA756660A 1974-10-22 1975-10-22 Oil-free adjuvant composition,containing n-acetyl-muramyl-l-alanyl-d-glutamatic acid as an active principle ZA756660B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/516,991 US4186194A (en) 1973-10-23 1974-10-22 Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents

Publications (1)

Publication Number Publication Date
ZA756660B true ZA756660B (en) 1976-11-24

Family

ID=24057920

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA756660A ZA756660B (en) 1974-10-22 1975-10-22 Oil-free adjuvant composition,containing n-acetyl-muramyl-l-alanyl-d-glutamatic acid as an active principle
ZA756661A ZA756661B (en) 1974-10-22 1975-10-22 Oil-free adjuvant composition,containing n-acetyl-muramyl-l-alanyl-d-isoglutamine as an active principle

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA756661A ZA756661B (en) 1974-10-22 1975-10-22 Oil-free adjuvant composition,containing n-acetyl-muramyl-l-alanyl-d-isoglutamine as an active principle

Country Status (3)

Country Link
BE (2) BE834754R (en)
FR (1) FR2288527A2 (en)
ZA (2) ZA756660B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4397844A (en) * 1978-02-24 1983-08-09 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation
FR2428050A1 (en) * 1978-06-05 1980-01-04 Anvar OLIGOMERS OF MURAMYL-PEPTIDE COMPOUNDS AND DRUGS CONTAINING THEM
US4368190A (en) 1980-04-17 1983-01-11 Merck & Co., Inc. Immunologically active dipeptidyl 4-O-,6-O-acyl-2-amino-2-deoxy-D-glucose derivatives and methods for their preparation
US4310514A (en) 1980-05-05 1982-01-12 Merck & Co., Inc. Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
US4315913A (en) 1980-06-09 1982-02-16 Merck & Co. Inc. Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation
FR2529463B1 (en) * 1982-07-05 1986-01-10 Centre Nat Rech Scient METHOD AND DEVICE FOR THE ENCAPSULATION IN ERYTHROCYTES OF AT LEAST ONE BIOLOGICALLY ACTIVE SUBSTANCE, IN PARTICULAR ALLOSTERIC EFFECTORS OF HEMOGLOBIN AND ERYTHROCYTES OBTAINED THEREBY
FR2533827A1 (en) * 1982-09-30 1984-04-06 Anvar Composition possessing immunoregulatory properties, in particular of non-specific immunological adjuvants, based on muramyl peptide and an aluminium derivative

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2160326B1 (en) * 1971-11-19 1975-02-07 Anvar
US4186194A (en) * 1973-10-23 1980-01-29 Agence Nationale De Valorisation De La Recherche (Anvar) Water soluble agents effective as immunological adjuvants for stimulating, in the host the immune response to various antigens and compositions, notably vaccines containing said water soluble agents

Also Published As

Publication number Publication date
BE834753R (en) 1976-02-16
BE834754R (en) 1976-02-16
ZA756661B (en) 1976-11-24
FR2288527A2 (en) 1976-05-21
FR2288527B2 (en) 1979-09-14

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