ES472430A1 - Procedimiento para purificar heparina. - Google Patents

Procedimiento para purificar heparina.

Info

Publication number
ES472430A1
ES472430A1 ES472430A ES472430A ES472430A1 ES 472430 A1 ES472430 A1 ES 472430A1 ES 472430 A ES472430 A ES 472430A ES 472430 A ES472430 A ES 472430A ES 472430 A1 ES472430 A1 ES 472430A1
Authority
ES
Spain
Prior art keywords
heparin
oxalates
freed
mineral salts
ppm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES472430A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Choay SA
Original Assignee
Choay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB33170/77A external-priority patent/GB1602439A/en
Application filed by Choay SA filed Critical Choay SA
Publication of ES472430A1 publication Critical patent/ES472430A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un procedimiento para purificar heparina, particularmente para eliminar su contenido de sales minerales, incluyendo oxalatos, que comprende añadir a una disolución acuosa de dicha heparina en una forma soluble una cantidad de una agente precipitante no iónico, tal como alcohol, ajustada de modo que cause la precipitación selectiva de la heparina o las sales de heparina, mientras las sales minerales quedan en la disolución acuosa, recuperar la heparina, y, si se precisa, repetir esta separación selectiva sobre una nueva disolución acuosa de la heparina así recuperada, hasta que la concentración de oxalato en la heparina final es de menos de 70 ppm, preferiblemente menos de 30ppm, y preferiblemente incluso menos de 20 ppm.
ES472430A 1977-08-08 1978-08-08 Procedimiento para purificar heparina. Expired ES472430A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB33170/77A GB1602439A (en) 1977-08-08 1977-08-08 Purified heparin
GB5204777 1977-12-14

Publications (1)

Publication Number Publication Date
ES472430A1 true ES472430A1 (es) 1979-03-16

Family

ID=26261753

Family Applications (1)

Application Number Title Priority Date Filing Date
ES472430A Expired ES472430A1 (es) 1977-08-08 1978-08-08 Procedimiento para purificar heparina.

Country Status (14)

Country Link
US (1) US4652555A (es)
JP (1) JPS5446809A (es)
AT (1) AT371713B (es)
AU (1) AU529432B2 (es)
CA (1) CA1105453A (es)
CH (1) CH636888A5 (es)
DE (1) DE2834702A1 (es)
DK (1) DK350078A (es)
ES (1) ES472430A1 (es)
FR (1) FR2400036A1 (es)
IE (1) IE47169B1 (es)
IT (1) IT1192564B (es)
NL (1) NL7808292A (es)
SE (1) SE447872B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2461719A2 (fr) * 1979-07-20 1981-02-06 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
ES2059321T3 (es) * 1986-05-16 1994-11-16 Italfarmaco Spa Heparinas, fracciones y fragmentos de heparinas libres de edta, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
AR243204A1 (es) * 1986-11-21 1993-07-30 Ajorca Sa Un metodo para la depolimerizacion quimica de polisacaridos.
SE8702254D0 (sv) * 1987-05-29 1987-05-29 Kabivitrum Ab Novel heparin derivatives
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
JP2001231595A (ja) * 1999-12-15 2001-08-28 Fuaruko Bio Syst:Kk 特異的破骨細胞由来酸性ホスファターゼの測定方法
JP4828795B2 (ja) * 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2283045A1 (en) * 2008-05-20 2011-02-16 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
ES2340902B1 (es) 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
CA3020369C (en) 2010-09-14 2019-11-26 University Of Miyazaki High purity heparin and production method therefor
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3135660A (en) * 1956-11-09 1964-06-02 Riker Laboratories Inc Method for purifying sulfated carbohydrates with oxidizing agents
US3482014A (en) * 1966-06-29 1969-12-02 Canada Packers Ltd Orally active heparin and method for making and using same
CA1042001A (en) * 1973-04-13 1978-11-07 Choay S.A. Mixed heparin salts
FR2225406A1 (en) * 1973-04-13 1974-11-08 Choay Sa Sodium-free heparin salts - by cation exchange of sodium salts, anticoagulants without side-effects

Also Published As

Publication number Publication date
AT371713B (de) 1983-07-25
AU3874878A (en) 1980-02-14
IE781616L (en) 1979-02-08
ATA577078A (de) 1982-12-15
DE2834702C2 (es) 1988-11-10
DK350078A (da) 1979-02-09
SE447872B (sv) 1986-12-22
NL7808292A (nl) 1979-02-12
IE47169B1 (en) 1984-01-11
US4652555A (en) 1987-03-24
JPS6129327B2 (es) 1986-07-05
AU529432B2 (en) 1983-06-09
JPS5446809A (en) 1979-04-13
DE2834702A1 (de) 1979-02-22
SE7808487L (sv) 1979-02-09
CH636888A5 (fr) 1983-06-30
IT7826580A0 (it) 1978-08-08
IT1192564B (it) 1988-04-20
FR2400036A1 (fr) 1979-03-09
CA1105453A (en) 1981-07-21
FR2400036B1 (es) 1980-09-19

Similar Documents

Publication Publication Date Title
ES472430A1 (es) Procedimiento para purificar heparina.
ES481841A1 (es) Un procedimiento de fabricacion de un producto autotranspi- rante de gran efectividad.
ES369852A1 (es) Procedimiento para preparar una composicion detergente po- bre en espuma.
ATE52033T1 (de) Verfahren zur herstellung eines lyophilisierten radiografischen abbildungsbestecks.
ES8306160A1 (es) "procedimiento para preparar un nuevo compuesto de cefem".
ES8401960A1 (es) Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas.
DE3474140D1 (en) Imidazole-ethanol esters
ATE27230T1 (de) Stimulans zur hauttalgabsonderung.
ES438931A1 (es) Procedimiento para la preparacion de nuevos derivados de amino-3 hidroxi-2 fenoxi-1 propano.
ES439309A1 (es) Un metodo para impedir la corrosion de metales en contacto con un liquido acuoso.
ES8303085A1 (es) Un procedimiento para la preparacion de una composicion antitranspirante a base de sales de aluminio y zirconio.
CA1269383C (en) HERBICIDAL ESTERS OF 2,6-BIS-FLUOROMETHYLDIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID
ES450371A1 (es) Un procedimiento para la preparacion de un compuesto de 4- (hidioximetil) midazol.
ATE8649T1 (de) Eine kupferverbindung enthaltende polyvinylchloridmischung.
ES429026A2 (es) Un metodo para la recuperacion y la estabilizacion de grasa, sustancias grasas proteinas, sustancias proteinicas y pro- ductos de deterioracion de dichas sustancias.
ES390952A1 (es) Procedimiento para la preparacion de 2-piperidilcarbinoles.
FI812674L (fi) Foerbaettringar vilka beroer aminometylenfosfonsyraloesningar
JPS5236689A (en) Novel synthetic penicillins and their preparation process
JPS5344572A (en) 5-alkoxy-picolic acid, its preparation and hypotensives containing the same
JPS5415416A (en) Filamentous calcium additive for copper alloy
SU1517383A1 (ru) Композиция для защиты металлов от кислотной коррозии
ES454007A1 (es) Perfeccionamientos en instalaciones para el tratamiento de la combustion mediante oxidos metalicos
JPS52116421A (en) Stabilized ethylene bisdithiocarbamic acid metal salts* compositions containing said salts* stabilized compositions and process for stabilization thereof
JPS524499A (en) Improving method for stabilization during storage of phosphoric acid-s ilica composites
JPS5320435A (en) Remedies for hypertension

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980302