ES468737A1 - Un procedimiento para la preparacion de nuevas cefalospori- nas - Google Patents

Un procedimiento para la preparacion de nuevas cefalospori- nas

Info

Publication number
ES468737A1
ES468737A1 ES468737A ES468737A ES468737A1 ES 468737 A1 ES468737 A1 ES 468737A1 ES 468737 A ES468737 A ES 468737A ES 468737 A ES468737 A ES 468737A ES 468737 A1 ES468737 A1 ES 468737A1
Authority
ES
Spain
Prior art keywords
substituted
ureido
image
cephalosporin antibiotics
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES468737A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES468737A1 publication Critical patent/ES468737A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Procedimiento para la preparación de nuevos antibióticos del tipo de cefalosporina, con una mayor actividad contra los microorganismos Gram-negativos. En especial esta invención se refiere a un procedimiento para la preparación de nuevas cefalosporinas sustituidas en la posición 7 con un grupo arilacetamido que contiene un sustituyente alfa-ureido sustituido y en la posición 3 con un sustituyente carbamoiloximetilo. El procedimiento de preparación de los nuevos compuestos antibióticos cefalosporínicos de la siguiente fórmula estructural. **(Fórmula)**
ES468737A 1976-02-20 1978-04-12 Un procedimiento para la preparacion de nuevas cefalospori- nas Expired ES468737A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/660,197 US4061630A (en) 1976-02-20 1976-02-20 7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiotics

Publications (1)

Publication Number Publication Date
ES468737A1 true ES468737A1 (es) 1979-01-01

Family

ID=24648544

Family Applications (2)

Application Number Title Priority Date Filing Date
ES456083A Expired ES456083A1 (es) 1976-02-20 1977-02-18 Un procedimiento para la preparacion de nuevas cefalospori- nas.
ES468737A Expired ES468737A1 (es) 1976-02-20 1978-04-12 Un procedimiento para la preparacion de nuevas cefalospori- nas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES456083A Expired ES456083A1 (es) 1976-02-20 1977-02-18 Un procedimiento para la preparacion de nuevas cefalospori- nas.

Country Status (18)

Country Link
US (1) US4061630A (es)
JP (1) JPS52102294A (es)
AU (1) AU509375B2 (es)
BE (1) BE851632A (es)
CA (1) CA1133895A (es)
CH (1) CH636622A5 (es)
DE (1) DE2707060A1 (es)
DK (1) DK73377A (es)
ES (2) ES456083A1 (es)
FI (1) FI770503A (es)
FR (1) FR2341583A1 (es)
GB (1) GB1574182A (es)
IE (1) IE44761B1 (es)
IL (1) IL51430A (es)
NL (1) NL7701663A (es)
NZ (1) NZ183310A (es)
SE (1) SE7701844L (es)
ZA (1) ZA77715B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479711A (en) * 1973-06-12 1977-07-13 Beecham Group Ltd Acylureido cephalosporins
CH634848A5 (de) * 1976-08-17 1983-02-28 Fujisawa Pharmaceutical Co Verfahren zur herstellung neuer 7-(n-substituierter 2-phenylglycinamido)-3-substituierte-3-cephem-4-carbonsaeuren.
DK225179A (da) * 1978-06-22 1979-12-23 Chugai Pharmaceutical Co Ltd Fremgangsmaade til fremstilling af cephalosporinderivater
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
JPS58135892A (ja) * 1982-02-05 1983-08-12 Chugai Pharmaceut Co Ltd セフアロスポリン誘導体

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3706746A (en) * 1968-11-07 1972-12-19 Ciba Geigy Corp O-desacetyl derivatives of 7-n-acylamino-cephalosphoranic acids
US3687949A (en) * 1969-01-21 1972-08-29 Bristol Myers Co Synthetic cephalosporins
US3673183A (en) * 1969-11-17 1972-06-27 Squibb & Sons Inc {60 -ureidocephalosporanic acid compounds
US3741962A (en) * 1971-05-21 1973-06-26 Squibb & Sons Inc Alpha-thioureidocephalosporanic acid compounds
GB1479711A (en) * 1973-06-12 1977-07-13 Beecham Group Ltd Acylureido cephalosporins
DE2354219A1 (de) * 1973-10-30 1975-05-07 Bayer Ag Beta-lactam-antibiotica, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3956292A (en) * 1974-04-01 1976-05-11 Eli Lilly And Company 7-(α-FUROYLUREIDOARYL AND CYCLOHEXADIENYLACETAMIDO) CEPHALOSPORIN ANTIBIOTICS

Also Published As

Publication number Publication date
DE2707060A1 (de) 1977-08-25
IL51430A0 (en) 1977-04-29
AU2244177A (en) 1978-08-24
DK73377A (da) 1977-08-21
ES456083A1 (es) 1978-10-16
SE7701844L (sv) 1977-08-21
US4061630A (en) 1977-12-06
FR2341583A1 (fr) 1977-09-16
BE851632A (fr) 1977-08-18
JPS52102294A (en) 1977-08-27
FR2341583B1 (es) 1980-02-29
CH636622A5 (de) 1983-06-15
IE44761B1 (en) 1982-03-24
IE44761L (en) 1977-08-20
CA1133895A (en) 1982-10-19
NL7701663A (nl) 1977-08-23
NZ183310A (en) 1978-11-13
AU509375B2 (en) 1980-05-08
IL51430A (en) 1981-07-31
GB1574182A (en) 1980-09-03
FI770503A (es) 1977-08-21
ZA77715B (en) 1978-09-27

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