ES467931A1 - Procedimiento para la obtencion de piridinil-aminoalquilete-res - Google Patents

Procedimiento para la obtencion de piridinil-aminoalquilete-res

Info

Publication number
ES467931A1
ES467931A1 ES467931A ES467931A ES467931A1 ES 467931 A1 ES467931 A1 ES 467931A1 ES 467931 A ES467931 A ES 467931A ES 467931 A ES467931 A ES 467931A ES 467931 A1 ES467931 A1 ES 467931A1
Authority
ES
Spain
Prior art keywords
aminoalkyl ethers
pyridinyl
pyridinyl aminoalkyl
ethers
oxides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467931A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Publication of ES467931A1 publication Critical patent/ES467931A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C2204/00—Features not otherwise provided for
    • A61C2204/002—Features not otherwise provided for using batteries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedimiento para la obtención de piridinil- aminoalquiléteres, de fórmula general: **(Fórmula)** en la que R1 significa hidrógeno, alquilo con 1 a 5 átomos de C o bencilo, R2 y R3 son iguales o diferentes y significan hidrógeno, alquilo con 1 a 3 átomos de C, metilo, formilo, carboxilo, alcoxicaronilo con 1 a 4 átomos de C, sustituidos por hidroxi, alcoxi, alquiltio o dialquilamino con cada vez 1 a 4 átomos en el alquilo, o nitrilo, o R2 y R3 constituyen juntos el radical -Ch2-B-CH2- formando un anillo con 3 miembros con el átomo de C que los une, y en el cual B es metileno, un átomo de oxigeno, azufre o nitrógeno, pudiendo el átomo de nitrógeno estar sustituido por alquilo con 1 a 5 átomos de C o fenilo, R4 es hidrógeno, fenilo, bencilo, o - feniletilo, pudiendo los anillos fenilo estar sustituidos por hidroxi, halógeno, alquilo o alcoxi, con 1 a 3 átomos de C en el alquilo, y siendo al menos dos de los radicales R1 a R4 desigual a hidrógeno, y A es una cadena de alquileno lineal o ramificada y en caso dado insaturada con 2 a 8 átomos de C y R5 y R6 tienen los significados indicados en la reivindicación 1, y sus sales de adición ácidas fisiológicamente tolerables.
ES467931A 1977-03-17 1978-03-16 Procedimiento para la obtencion de piridinil-aminoalquilete-res Expired ES467931A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772711655 DE2711655A1 (de) 1977-03-17 1977-03-17 Pyridinyl-aminoalkylaether

Publications (1)

Publication Number Publication Date
ES467931A1 true ES467931A1 (es) 1979-07-01

Family

ID=6003884

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467931A Expired ES467931A1 (es) 1977-03-17 1978-03-16 Procedimiento para la obtencion de piridinil-aminoalquilete-res

Country Status (27)

Country Link
US (1) US4206117A (es)
JP (1) JPS53116382A (es)
AT (2) AT364360B (es)
AU (1) AU525566B2 (es)
BE (1) BE864917A (es)
CA (1) CA1108148A (es)
CH (1) CH638186A5 (es)
CS (2) CS202011B2 (es)
DD (1) DD134090A5 (es)
DE (1) DE2711655A1 (es)
DK (1) DK118578A (es)
ES (1) ES467931A1 (es)
FI (1) FI74962C (es)
FR (1) FR2383930A1 (es)
GB (1) GB1599061A (es)
GR (1) GR64096B (es)
HU (1) HU177287B (es)
IE (1) IE46484B1 (es)
IL (1) IL54265A0 (es)
IT (1) IT1093796B (es)
LU (1) LU79235A1 (es)
NL (1) NL189563C (es)
NO (1) NO150605C (es)
SE (1) SE446185B (es)
SU (2) SU799658A3 (es)
YU (2) YU63678A (es)
ZA (1) ZA781552B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474781A (en) * 1979-04-02 1984-10-02 Merck & Co., Inc. Treating hypertension with aminoalkoxypyridines
DE3008522A1 (de) * 1980-03-06 1981-09-17 Basf Ag, 6700 Ludwigshafen 4-(alpha)-cycloamino-arylmethyl-6-methyl-1,3-dihydro-furo (3,4-c) -pyridin-7-ole, ihre herstellung und verwendung
IL62602A (en) * 1980-05-19 1984-06-29 Labaz Sanofi Nv Pyridoxine derivatives,their preparation and pharmaceutical compositions containing them
JPS588066A (ja) * 1981-07-03 1983-01-18 Otsuka Pharmaceut Co Ltd 光学活性〔ｓ〕−（−）−カルボスチリル誘導体の製造法
EP0097000B1 (en) * 1982-06-10 1987-09-09 Beecham Wuelfing GmbH & Co KG Amine derivatives
DE3519693A1 (de) * 1985-06-01 1987-01-02 Basf Ag Pyridin-derivate, ihre herstellung und verwendung
GB8603475D0 (en) * 1986-02-12 1986-03-19 Glaxo Group Ltd Chemical compounds
GB8703007D0 (en) * 1987-02-10 1987-03-18 Glaxo Group Ltd Chemical compounds
GB9012926D0 (en) * 1990-06-09 1990-08-01 Scras Pyrrolo-pyridine derivatives
JP2829451B2 (ja) 1990-11-30 1998-11-25 大塚製薬株式会社 活性酸素抑制剤
MY128323A (en) 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
US20010034357A1 (en) * 2000-02-02 2001-10-25 Nan-Horng Lin Substituted pyridine compounds useful for controlling chemical synaptic transmission
US20070208026A1 (en) * 2003-04-07 2007-09-06 Liu Kevin N-Containing Heteroaromatic Compounds As Modulators Of Ppars And Methods Of Treating Metabolic Disorders
CN106243100B (zh) 2008-10-10 2019-04-09 Vm生物医药公司 治疗酒精使用障碍，疼痛和其他疾病的药物组合与方法
KR101698153B1 (ko) * 2010-04-26 2017-01-23 광주과학기술원 Ｐ2ｘ1 및 ｐ2ｘ3 수용체 길항제로 사용되는 신규한 피리딘 카르복실산계 화합물, 이의 제조방법 및 이를 포함하는 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1572768A (en) * 1925-06-26 1926-02-09 Winthrop Chem Co Inc Pharmaceutical product
US1881236A (en) * 1929-08-10 1932-10-04 Soc Of Chemical Ind Basic ethers of the pyridine series
US3535328A (en) * 1967-09-01 1970-10-20 Exxon Research Engineering Co Certain substituted aminothioethoxy pyridines
AR206801A1 (es) * 1973-02-20 1976-08-23 Ciba Geigy Ag Procedimiento para la elaboracion de derivados del 1-pirid loxi-2-hidroxi-3-amino-propano
US4115575A (en) * 1973-02-20 1978-09-19 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)-pyrazines
US4073909A (en) * 1973-10-08 1978-02-14 Sandoz Ltd. Isoquinoline compounds
CH591448A5 (es) 1974-05-14 1977-09-15 Ciba Geigy Ag
CH614711A5 (es) * 1975-04-08 1979-12-14 Sandoz Ag
GB1504424A (en) * 1975-08-09 1978-03-22 Beecham Group Ltd Isoquinoline-derived aminoethers
GB1485919A (en) 1975-08-12 1977-09-14 Grindstedvaerket As Pyridine derivatives
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines

Also Published As

Publication number Publication date
IT7821099A0 (it) 1978-03-10
CS202012B2 (en) 1980-12-31
DK118578A (da) 1978-09-18
IL54265A0 (en) 1978-06-15
FR2383930B1 (es) 1982-10-22
CA1108148A (en) 1981-09-01
US4206117A (en) 1980-06-03
ATA84080A (de) 1981-03-15
FR2383930A1 (fr) 1978-10-13
DE2711655C2 (es) 1987-07-16
IT1093796B (it) 1985-07-26
AT364361B (de) 1981-10-12
YU225282A (en) 1983-02-28
AU3419578A (en) 1979-09-20
YU63678A (en) 1983-01-21
YU41016B (en) 1986-10-31
LU79235A1 (de) 1978-06-28
NL189563B (nl) 1992-12-16
NL189563C (nl) 1993-05-17
GR64096B (en) 1980-01-22
BE864917A (fr) 1978-09-15
GB1599061A (en) 1981-09-30
SE7802927L (sv) 1978-09-18
NO150605B (no) 1984-08-06
IE46484B1 (en) 1983-06-29
IE780503L (en) 1978-09-17
FI780842A (fi) 1978-09-18
ATA187878A (de) 1981-03-15
DD134090A5 (de) 1979-02-07
JPS6123790B2 (es) 1986-06-07
CS202011B2 (en) 1980-12-31
SE446185B (sv) 1986-08-18
CH638186A5 (de) 1983-09-15
JPS53116382A (en) 1978-10-11
SU799658A3 (ru) 1981-01-23
AT364360B (de) 1981-10-12
NL7802719A (nl) 1978-09-19
NO150605C (no) 1984-11-14
FI74962B (fi) 1987-12-31
FI74962C (fi) 1988-04-11
HU177287B (en) 1981-09-28
ZA781552B (en) 1979-04-25
DE2711655A1 (de) 1978-09-21
AU525566B2 (en) 1982-11-11
SU850002A3 (ru) 1981-07-23
NO780931L (no) 1978-09-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990503