ES461342A1 - Procedimiento de sintesis estereoespecifica de pirrolidinas opticamente activas. - Google Patents
Procedimiento de sintesis estereoespecifica de pirrolidinas opticamente activas.Info
- Publication number
- ES461342A1 ES461342A1 ES461342A ES461342A ES461342A1 ES 461342 A1 ES461342 A1 ES 461342A1 ES 461342 A ES461342 A ES 461342A ES 461342 A ES461342 A ES 461342A ES 461342 A1 ES461342 A1 ES 461342A1
- Authority
- ES
- Spain
- Prior art keywords
- optically active
- reduction
- formula
- image
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003235 pyrrolidines Chemical class 0.000 title abstract 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 4
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000004705 aldimines Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229940054066 benzamide antipsychotics Drugs 0.000 abstract 1
- 150000003936 benzamides Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7623910A FR2360572A1 (fr) | 1976-08-05 | 1976-08-05 | Pyrrolidines substituees et leur preparation |
| FR7635476A FR2372157A1 (fr) | 1976-11-25 | 1976-11-25 | Procede de synthese stereospecifique de n-alkyl- pyrrolidines optiquement actives |
| FR7719391A FR2395261A2 (fr) | 1977-06-24 | 1977-06-24 | Pyrrolidines substituees et leur preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES461342A1 true ES461342A1 (es) | 1978-06-01 |
Family
ID=27250658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES461342A Expired ES461342A1 (es) | 1976-08-05 | 1977-08-04 | Procedimiento de sintesis estereoespecifica de pirrolidinas opticamente activas. |
Country Status (20)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1095415B (it) * | 1978-02-16 | 1985-08-10 | Ravizza Spa | Processo per la produzione di una benzamide otticamente attiva,benzamide otticamente attiva cosi'ottenuta e composizioni |
| IT1141095B (it) * | 1980-11-27 | 1986-10-01 | Ravizza Spa | Processo di risoluzione della sulpiride racema |
| SE8602339D0 (sv) * | 1986-05-22 | 1986-05-22 | Astra Laekemedel Ab | An efficient stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines |
| DE4425070A1 (de) * | 1994-07-15 | 1996-01-18 | Degussa | Verfahren zur Herstellung optisch aktiver l-substituierter 2-(Aminomethyl)pyrrolidine |
| CA2497062A1 (en) * | 2004-02-18 | 2005-08-18 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
| CN104086475B (zh) * | 2014-07-15 | 2016-10-05 | 苏州天马精细化学品股份有限公司 | 一种n-苄氧羰基-l-脯氨酰胺的制备方法 |
| CN106045869A (zh) * | 2016-06-30 | 2016-10-26 | 宜兴市前成生物有限公司 | 一种制备dl‑谷氨酸的方法 |
| CN117185977A (zh) * | 2023-09-20 | 2023-12-08 | 江苏阿尔法药业股份有限公司 | 一种氨磺必利中间体的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1528014A (fr) * | 1967-04-24 | 1968-06-07 | Ile De France | Procédé de préparation des isomères optiques de la éthyl-1, aminométhyl-2-pyrrolidine |
| CH507938A (fr) * | 1968-08-01 | 1971-05-31 | Ile De France | Procédé de préparation de benzamides hétérocycliques |
-
1977
- 1977-08-02 IL IL52645A patent/IL52645A/xx unknown
- 1977-08-03 NL NL7708571A patent/NL7708571A/xx not_active Application Discontinuation
- 1977-08-03 GR GR54101A patent/GR63594B/el unknown
- 1977-08-03 NZ NZ184832A patent/NZ184832A/xx unknown
- 1977-08-03 DE DE2735036A patent/DE2735036C2/de not_active Expired
- 1977-08-04 IE IE1633/77A patent/IE45544B1/en unknown
- 1977-08-04 FI FI772363A patent/FI772363A7/fi not_active Application Discontinuation
- 1977-08-04 LU LU77917A patent/LU77917A1/xx unknown
- 1977-08-04 IT IT26497/77A patent/IT1085696B/it active
- 1977-08-04 SE SE7708902A patent/SE7708902L/xx not_active Application Discontinuation
- 1977-08-04 CH CH959477A patent/CH624933A5/fr not_active IP Right Cessation
- 1977-08-04 DK DK350377A patent/DK350377A/da not_active Application Discontinuation
- 1977-08-04 ES ES461342A patent/ES461342A1/es not_active Expired
- 1977-08-04 NO NO772745A patent/NO772745L/no unknown
- 1977-08-04 JP JP9404477A patent/JPS5325563A/ja active Pending
- 1977-08-04 AU AU27641/77A patent/AU510454B2/en not_active Expired
- 1977-08-04 GB GB32790/77A patent/GB1555890A/en not_active Expired
- 1977-08-04 CA CA284,104A patent/CA1083586A/en not_active Expired
- 1977-08-04 PT PT66894A patent/PT66894B/pt unknown
- 1977-08-05 AT AT0577377A patent/AT364818B/de not_active IP Right Cessation
-
1980
- 1980-12-22 SE SE8009074A patent/SE8009074L/sv not_active Application Discontinuation
-
1981
- 1981-01-06 CH CH4181A patent/CH626341A5/fr not_active IP Right Cessation
- 1981-08-25 NO NO812871A patent/NO812871L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT66894B (fr) | 1979-01-26 |
| CA1083586A (en) | 1980-08-12 |
| SE7708902L (sv) | 1978-02-06 |
| IE45544L (en) | 1978-02-05 |
| IE45544B1 (en) | 1982-09-22 |
| DE2735036C2 (de) | 1983-10-13 |
| PT66894A (fr) | 1977-09-01 |
| DE2735036A1 (de) | 1978-02-16 |
| IL52645A (en) | 1980-02-29 |
| NL7708571A (nl) | 1978-02-07 |
| NZ184832A (en) | 1979-11-01 |
| CH624933A5 (enrdf_load_stackoverflow) | 1981-08-31 |
| ATA577377A (de) | 1981-04-15 |
| DK350377A (da) | 1978-02-06 |
| GR63594B (en) | 1979-11-26 |
| IT1085696B (it) | 1985-05-28 |
| JPS5325563A (en) | 1978-03-09 |
| FI772363A7 (enrdf_load_stackoverflow) | 1978-02-06 |
| NO812871L (no) | 1978-02-07 |
| IL52645A0 (en) | 1977-10-31 |
| SE8009074L (sv) | 1980-12-22 |
| CH626341A5 (en) | 1981-11-13 |
| AU510454B2 (en) | 1980-06-26 |
| AU2764177A (en) | 1979-02-08 |
| AT364818B (de) | 1981-11-25 |
| GB1555890A (en) | 1979-11-14 |
| LU77917A1 (enrdf_load_stackoverflow) | 1977-11-14 |
| NO772745L (no) | 1978-02-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971103 |