GB1380382A - Preparation of 3-fluoro-d-alanine - Google Patents
Preparation of 3-fluoro-d-alanineInfo
- Publication number
- GB1380382A GB1380382A GB508773A GB508773A GB1380382A GB 1380382 A GB1380382 A GB 1380382A GB 508773 A GB508773 A GB 508773A GB 508773 A GB508773 A GB 508773A GB 1380382 A GB1380382 A GB 1380382A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fluoro
- alanine
- feb
- reacting
- propionic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
1380382 3-Fluoro-D-alanine MERCK & CO Inc 1 Feb 1973 [3 Feb 1972] 5087/73 Heading C2C 3-Fluoro-D-alanine is obtained by reacting fluoropyruvic acid with an optically active D- amino compound forming the corresponding D-ketimine, reacting the latter with hydrogen or deuterium in the presence of a hydrogenation catalyst forming the corresponding N-substituted 3-fluoro-D-alanine, and catalytically hydrogenolyzing the latter to remove the N- substituent and form 3-fluoro-D-alanine or 2-deutero-3-fluoro-D- alanine. Suitable D-amino compounds are R(D)-phenyl glycine which forms corresponding intermediates 2-(D-α-carboxybenzylimino)-3-fluoro-propionic acid and N-(D)- carboxybenzyl) - 3 - fluoro - D - alanine, and D-α-methylbenzylamine which forms intermediates 2 - (D - α - methylbenzylimino) - 3- fluoro - propionic acid and N - (D - α - methylbenzyl)-3-fluoro-D -alanine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22335572A | 1972-02-03 | 1972-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1380382A true GB1380382A (en) | 1975-01-15 |
Family
ID=22836157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB508773A Expired GB1380382A (en) | 1972-02-03 | 1973-02-01 | Preparation of 3-fluoro-d-alanine |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS4885524A (en) |
| AR (2) | AR200994A1 (en) |
| AT (1) | AT324294B (en) |
| AU (1) | AU467773B2 (en) |
| CA (1) | CA1001652A (en) |
| CH (1) | CH585694A5 (en) |
| CS (1) | CS178418B2 (en) |
| DD (2) | DD114594A5 (en) |
| DE (1) | DE2305256A1 (en) |
| ES (1) | ES411143A1 (en) |
| FR (2) | FR2170180B1 (en) |
| GB (1) | GB1380382A (en) |
| HU (1) | HU168659B (en) |
| NL (1) | NL7300577A (en) |
| PL (1) | PL84511B1 (en) |
| SU (1) | SU485592A3 (en) |
| ZA (1) | ZA73777B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7511733L (en) * | 1974-11-08 | 1976-05-10 | Merck & Co Inc | SYNTHESIS OF RECEMICAL 3-FLUORO-ALANINE AND SALTS THEREOF, AND INTERMEDIATE PRODUCT IN THIS SYNTHESIS |
| EP0798289B1 (en) * | 1996-03-29 | 2001-03-07 | F. Hoffmann-La Roche Ag | Alpha-Iminocarboxylic acid derivative |
| CN107715870A (en) * | 2017-10-13 | 2018-02-23 | 西安凯立新材料股份有限公司 | A kind of preparation method and application for preparing L aminopropanol ruthenium Pd/carbon catalysts |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7207606A (en) * | 1971-06-18 | 1972-12-20 |
-
1973
- 1973-01-15 NL NL7300577A patent/NL7300577A/xx not_active Application Discontinuation
- 1973-01-22 CS CS478A patent/CS178418B2/cs unknown
- 1973-01-23 AU AU51369/73A patent/AU467773B2/en not_active Expired
- 1973-01-24 AR AR246271A patent/AR200994A1/en active
- 1973-01-24 CA CA161,915A patent/CA1001652A/en not_active Expired
- 1973-01-30 AT AT79073A patent/AT324294B/en not_active IP Right Cessation
- 1973-01-31 PL PL1973160498A patent/PL84511B1/en unknown
- 1973-01-31 ES ES411143A patent/ES411143A1/en not_active Expired
- 1973-02-01 DD DD181401*A patent/DD114594A5/xx unknown
- 1973-02-01 GB GB508773A patent/GB1380382A/en not_active Expired
- 1973-02-01 DD DD168612A patent/DD108522A5/xx unknown
- 1973-02-02 DE DE19732305256 patent/DE2305256A1/en not_active Ceased
- 1973-02-02 ZA ZA730777A patent/ZA73777B/en unknown
- 1973-02-02 FR FR7303666A patent/FR2170180B1/fr not_active Expired
- 1973-02-02 CH CH148973A patent/CH585694A5/xx not_active IP Right Cessation
- 1973-02-02 HU HUME1599A patent/HU168659B/hu unknown
- 1973-02-02 SU SU1878868A patent/SU485592A3/en active
- 1973-02-02 JP JP48013024A patent/JPS4885524A/ja active Pending
- 1973-10-01 FR FR7335004A patent/FR2197859B1/fr not_active Expired
- 1973-11-05 AR AR250835A patent/AR202539A1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| NL7300577A (en) | 1973-08-07 |
| HU168659B (en) | 1976-06-28 |
| ES411143A1 (en) | 1975-12-01 |
| ZA73777B (en) | 1974-10-30 |
| FR2170180B1 (en) | 1977-04-22 |
| JPS4885524A (en) | 1973-11-13 |
| CA1001652A (en) | 1976-12-14 |
| AU467773B2 (en) | 1975-12-11 |
| FR2197859A1 (en) | 1974-03-29 |
| AU5136973A (en) | 1974-07-25 |
| DE2305256A1 (en) | 1973-08-09 |
| AT324294B (en) | 1975-08-25 |
| CH585694A5 (en) | 1977-03-15 |
| FR2197859B1 (en) | 1977-05-27 |
| DD108522A5 (en) | 1974-09-20 |
| SU485592A3 (en) | 1975-09-25 |
| FR2170180A1 (en) | 1973-09-14 |
| DD114594A5 (en) | 1975-08-12 |
| PL84511B1 (en) | 1976-04-30 |
| CS178418B2 (en) | 1977-09-15 |
| AR200994A1 (en) | 1975-02-06 |
| AR202539A1 (en) | 1975-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |