ES460686A1 - Un procedimiento para la preparacion de 5-m-tolioxiuracilo. - Google Patents
Un procedimiento para la preparacion de 5-m-tolioxiuracilo.Info
- Publication number
- ES460686A1 ES460686A1 ES460686A ES460686A ES460686A1 ES 460686 A1 ES460686 A1 ES 460686A1 ES 460686 A ES460686 A ES 460686A ES 460686 A ES460686 A ES 460686A ES 460686 A1 ES460686 A1 ES 460686A1
- Authority
- ES
- Spain
- Prior art keywords
- tolyloxyuracil
- ulcer agent
- ulcer
- agent
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
Un procedimiento para la preparación de 5-m-toliloxiuracilo de la fórmula **fórmula** en su forma ceto o en su forma enol, así como de sus sales farmacéuticamente aceptables, caracterizado porque comprende las operaciones de hacer reaccionar 5-(m-toliloxi)-2- tiouracilo con una cantidad equivalente o en exceso de un ácido alfa-halogeno acético, hidrolizar el producto resultante de la reacción anterior en un ácido mineral acuoso , y aislar el producto de hidrólisis resultantes antes o después de convertirlo opcionalmente en una sal farmacéuticamente aceptable del mismo
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/706,123 US4080454A (en) | 1976-07-16 | 1976-07-16 | 5-M-Tolyloxyuracil, anti-ulcer agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES460686A1 true ES460686A1 (es) | 1978-12-01 |
Family
ID=24836300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES460686A Expired ES460686A1 (es) | 1976-07-16 | 1977-07-13 | Un procedimiento para la preparacion de 5-m-tolioxiuracilo. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4080454A (es) |
| JP (1) | JPS5337673A (es) |
| AR (1) | AR213652A1 (es) |
| AT (1) | AT351561B (es) |
| BE (1) | BE856710A (es) |
| CA (1) | CA1061788A (es) |
| CH (1) | CH622512A5 (es) |
| CS (1) | CS212264B2 (es) |
| DD (1) | DD131556A5 (es) |
| DE (1) | DE2731736A1 (es) |
| DK (1) | DK139029B (es) |
| EG (1) | EG12762A (es) |
| ES (1) | ES460686A1 (es) |
| FI (1) | FI772183A (es) |
| FR (1) | FR2358399A1 (es) |
| GB (1) | GB1542178A (es) |
| GR (1) | GR68686B (es) |
| HU (1) | HU177713B (es) |
| IL (1) | IL52409A (es) |
| LU (1) | LU77764A1 (es) |
| NL (1) | NL7707729A (es) |
| NO (1) | NO772489L (es) |
| PH (1) | PH13190A (es) |
| PL (1) | PL103783B1 (es) |
| PT (1) | PT66808B (es) |
| SE (1) | SE421125B (es) |
| SU (1) | SU673169A3 (es) |
| YU (1) | YU171677A (es) |
| ZA (1) | ZA773927B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55158095A (en) * | 1979-05-25 | 1980-12-09 | Zenkosha Tokei Kk | Controller for washing machine |
| JPS5822406U (ja) * | 1981-08-04 | 1983-02-12 | トキコ株式会社 | 消音器 |
| JP5113752B2 (ja) | 2005-08-22 | 2013-01-09 | メリオール・ファーマスーティカルズ・ワン・インコーポレイテッド | Ｌｙｎキナーゼの活性を調節し、関連する疾患を治療するための方法および製剤 |
| EP2120581A4 (en) * | 2007-02-20 | 2011-03-16 | Melior Pharmaceuticals I Inc | METHODS OF IDENTIFYING LYN KINASE ACTIVATORS |
| BRPI0813167A2 (pt) * | 2007-07-23 | 2014-12-23 | Melior Discovery Inc | Usos de uma composição e de um agente para modular a atividade e/ou a expressão de irs-1 e/ou akt, e, composto |
| US8552184B2 (en) * | 2008-07-03 | 2013-10-08 | Melior Pharmaceuticals I, Inc. | Compounds and methods for treating disorders related to glucose metabolism |
| WO2011150300A1 (en) * | 2010-05-28 | 2011-12-01 | Melior Pharmaceuticals I, Inc. | Prevention of pancreatic beta cell degeneration |
| CN110785170B (zh) | 2017-04-10 | 2023-03-28 | 梅里奥尔医药I公司 | 脂肪细胞的治疗 |
| WO2019164799A1 (en) | 2018-02-21 | 2019-08-29 | Melior Pharmaceuticals I, Inc. | Treatment of liver diseases |
-
1976
- 1976-07-16 US US05/706,123 patent/US4080454A/en not_active Expired - Lifetime
-
1977
- 1977-06-27 GR GR53819A patent/GR68686B/el unknown
- 1977-06-27 CA CA281,423A patent/CA1061788A/en not_active Expired
- 1977-06-28 SE SE7707471A patent/SE421125B/xx unknown
- 1977-06-28 IL IL52409A patent/IL52409A/xx unknown
- 1977-06-29 ZA ZA00773927A patent/ZA773927B/xx unknown
- 1977-07-05 PH PH19953A patent/PH13190A/en unknown
- 1977-07-11 BE BE1008274A patent/BE856710A/xx unknown
- 1977-07-11 DE DE19772731736 patent/DE2731736A1/de not_active Withdrawn
- 1977-07-11 YU YU01716/77A patent/YU171677A/xx unknown
- 1977-07-11 FR FR7721285A patent/FR2358399A1/fr active Granted
- 1977-07-12 NL NL7707729A patent/NL7707729A/xx not_active Application Discontinuation
- 1977-07-12 JP JP8349077A patent/JPS5337673A/ja active Granted
- 1977-07-13 EG EG418/77A patent/EG12762A/xx active
- 1977-07-13 FI FI772183A patent/FI772183A/fi not_active Application Discontinuation
- 1977-07-13 CH CH870277A patent/CH622512A5/fr not_active IP Right Cessation
- 1977-07-13 SU SU772502606A patent/SU673169A3/ru active
- 1977-07-13 HU HU77PI583A patent/HU177713B/hu unknown
- 1977-07-13 CS CS774680A patent/CS212264B2/cs unknown
- 1977-07-13 DK DK318177AA patent/DK139029B/da unknown
- 1977-07-13 ES ES460686A patent/ES460686A1/es not_active Expired
- 1977-07-13 NO NO772489A patent/NO772489L/no unknown
- 1977-07-14 GB GB7729667A patent/GB1542178A/en not_active Expired
- 1977-07-14 PT PT66808A patent/PT66808B/pt unknown
- 1977-07-14 PL PL1977199633A patent/PL103783B1/pl unknown
- 1977-07-14 AT AT509277A patent/AT351561B/de not_active IP Right Cessation
- 1977-07-14 DD DD7700200058A patent/DD131556A5/xx unknown
- 1977-07-14 AR AR268432A patent/AR213652A1/es active
- 1977-07-14 LU LU77764A patent/LU77764A1/xx unknown
Also Published As
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