ES459504A1 - Procedimiento para la preparacion de derivados de la 4-hi- droxi-aporfina. - Google Patents

Procedimiento para la preparacion de derivados de la 4-hi- droxi-aporfina.

Info

Publication number
ES459504A1
ES459504A1 ES459504A ES459504A ES459504A1 ES 459504 A1 ES459504 A1 ES 459504A1 ES 459504 A ES459504 A ES 459504A ES 459504 A ES459504 A ES 459504A ES 459504 A1 ES459504 A1 ES 459504A1
Authority
ES
Spain
Prior art keywords
derivatives
aporphine derivatives
aporphine
concerned
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES459504A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES459504A1 publication Critical patent/ES459504A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de derivados de la 4-hidroxi-aporfina , que responde a la fórmula general: *** ver imagen 01 en la que R¿1, R¿2, R¿3 y R¿4, que pueden ser iguales o diferentes, son radicales metilo o etilo R¿5 es un átomo de hidrógeno o un radical alquilo de cadena recta, cíclica o ratificada que contiene hasta 5 átomos de carbono y el símbolo X¿ o Y¿ en la posición trans con el átomo de hidrógeno 6ª representa un grupo hidroxilo, mientras que el otro símbolo X¿ o Y¿ representa un átomo de hidrógeno, y de las sales de los mismos con ácidos orgánicos e inorgánicos, en el que se cicliza un compuesto de la fórmula general (II) *** ver imagen 02
ES459504A 1976-06-04 1977-06-04 Procedimiento para la preparacion de derivados de la 4-hi- droxi-aporfina. Expired ES459504A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2625116A DE2625116C2 (de) 1976-06-04 1976-06-04 Verfahren zur Herstellung von 4-Hydroxy-aporphin-Derivaten

Publications (1)

Publication Number Publication Date
ES459504A1 true ES459504A1 (es) 1978-05-01

Family

ID=5979808

Family Applications (1)

Application Number Title Priority Date Filing Date
ES459504A Expired ES459504A1 (es) 1976-06-04 1977-06-04 Procedimiento para la preparacion de derivados de la 4-hi- droxi-aporfina.

Country Status (14)

Country Link
US (1) US4120964A (es)
JP (1) JPS535169A (es)
AU (1) AU508171B2 (es)
BE (1) BE855412A (es)
CH (1) CH629782A5 (es)
DE (1) DE2625116C2 (es)
DK (1) DK248277A (es)
ES (1) ES459504A1 (es)
FR (1) FR2353534A1 (es)
GB (1) GB1521020A (es)
IE (1) IE44937B1 (es)
LU (1) LU77482A1 (es)
NL (1) NL7706180A (es)
SE (1) SE433212B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757335C3 (de) * 1977-12-22 1982-03-25 Gödecke AG, 1000 Berlin Verfahren zur O-Methylierung von Hydroxyaporphinen
DE2757281C3 (de) * 1977-12-22 1980-10-23 Goedecke Ag, 1000 Berlin Verfahren zur Herstellung von 1 -Hydroxy-Aporphinderivaten
FI68813C (fi) * 1978-08-21 1985-11-11 Dow Chemical Co Foerfarande foer framstaellning av terapeutiskt effektiva 1- och d,1-glausinfosfatsalter
DE3324089A1 (de) * 1983-07-05 1985-01-17 Basf Ag, 6700 Ludwigshafen Elektrophotographische aufzeichnungsmaterialien mit verbesserter photoempfindlichkeit
DE3324090A1 (de) * 1983-07-05 1985-01-17 Basf Ag, 6700 Ludwigshafen Elektrophotographische aufzeichnungsmaterialien mit verbesserter photoempfindlichkeit
US5156847A (en) * 1990-09-20 1992-10-20 Walter H. Lewis Wound-healing composition
US5474782A (en) * 1994-05-20 1995-12-12 Woundfast Pharmaceuticals, Inc. Wound-healing composition and method
US5659037A (en) * 1994-08-18 1997-08-19 Abbott Laboratories Process for preparing chiral tetracyclic dopaminergic compounds
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US5932617A (en) * 1998-02-06 1999-08-03 Woundfast Pharmaceuticals Inc. Wound-treating composition and method
US6210680B1 (en) 1999-06-11 2001-04-03 Univera Pharmaceuticals, Inc. Method for the prevention and treatment of chronic venous insufficiency
US20030187011A1 (en) * 2001-12-20 2003-10-02 Lashuel Hilal A. Apomorphine inhibitors of amyloid-beta (Abeta) fibril formation and their use in amyloidosis based disease
TWI404536B (zh) * 2008-06-20 2013-08-11 Standard Chem & Pharm Co Ltd 阿朴芬化合物及其醫藥用途
CN105315208A (zh) * 2014-07-17 2016-02-10 中国科学院兰州化学物理研究所 阿朴菲类生物碱及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3131191A (en) * 1962-08-08 1964-04-28 Smith Kline French Lab Process for the preparation of noraporphines

Also Published As

Publication number Publication date
AU2580977A (en) 1978-12-07
LU77482A1 (es) 1977-09-22
BE855412A (fr) 1977-12-05
JPS535169A (en) 1978-01-18
CH629782A5 (de) 1982-05-14
IE44937B1 (en) 1982-05-19
DE2625116A1 (de) 1977-12-22
GB1521020A (en) 1978-08-09
IE44937L (en) 1977-12-04
DK248277A (da) 1977-12-05
US4120964A (en) 1978-10-17
SE433212B (sv) 1984-05-14
DE2625116C2 (de) 1984-01-26
SE7706488L (sv) 1977-12-05
FR2353534B1 (es) 1980-03-07
FR2353534A1 (fr) 1977-12-30
AU508171B2 (en) 1980-03-13
NL7706180A (nl) 1977-12-06

Similar Documents

Publication Publication Date Title
GB1547389A (en) Counterbalancing arrangements and lamps incorporating the same
NZ184527A (en) Preparation of 6a,10a-transhexahydro-dibenzo-(b,d)pyran-9-ones
GB1537130A (en) 6,9,21-trihalo-steroids of the pregnane series
ES459504A1 (es) Procedimiento para la preparacion de derivados de la 4-hi- droxi-aporfina.
YU262776A (en) Arrangement for measuring and controlling, respectively, the dimensions of objects
SE436026B (sv) Forfarande for framstellning av 13,14-dehydroprostaglandiner
RO75589A (ro) Procedeu pentru prepararea 2,6-metan-2h-1-benzoxocinei
NZ185962A (en) Stabilisation of 1,1,1-tricholorethane
JPS57136577A (en) Manufacture of 2,4-diamino-5-benzylpyrimidine
HK57784A (en) Novel anthracene-9,10-bis-carbonyl-hydrazones and derivatives
ZA773426B (en) New substituted 1,3-diphenoxypropan-2-ol derivatives and their manufacture and use
JPS5332305A (en) Stop ring
ES452736A1 (es) Un procedimiento para preparar compuestos de aroil-fenildi- deno y aroil-fenilnaftaleno.
IL53038A0 (en) The preparation of certain nuclearchlorinated benzotrichlorides
FR2317294A1 (fr) Preparation de 5-cyano-4 methyl-oxazole (1,3)
AU1429676A (en) 5%2,2 dihalovinyl<4,4 dimethyl 2 oxotetrahydrofurans and intermediates
IL52884A0 (en) The preparation of 2,3-cycloalkenopyridines
SU686454A1 (ru) Магнитореологическая суспензия
AU508239B2 (en) 1, 2, 3, 4-Tetrahydrobenzoisoquinolines and their use asanti-Aggressive Agents
CA1000001A (en) Garment
AU510764B2 (en) Preparation of 2, 3-Dichloroanisole
ES446051A1 (es) Procedimiento para la preparacion de azabicicloalcanis y compuestos intermedios de los mismos.
ES374657A1 (es) Un proceso para la preparacion de nuevos derivados susti- tuidos de 1,1-dicloro-alqueno-1-.
GB1554468A (en) Manufacture of 2,6,6-trimethyl-cyclohex-2 en-1-one
Ratcliffe Measurement of the social networks of psychiatric patients and normals

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990301