ES457417A1 - Un procedimiento para la preparacion de nuevos aminocromano-les. - Google Patents

Un procedimiento para la preparacion de nuevos aminocromano-les.

Info

Publication number
ES457417A1
ES457417A1 ES457417A ES457417A ES457417A1 ES 457417 A1 ES457417 A1 ES 457417A1 ES 457417 A ES457417 A ES 457417A ES 457417 A ES457417 A ES 457417A ES 457417 A1 ES457417 A1 ES 457417A1
Authority
ES
Spain
Prior art keywords
hypotensive
amino
ols
pyran
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES457417A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB13536/76A external-priority patent/GB1511187A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES457417A1 publication Critical patent/ES457417A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Un procedimiento para la preparación de nuevos aminocromanoles de fórmula (I) *** Donde R1 es un átomo de hidrógeno o un grupo alquilo de hasta 4 átomos de carbono opcionalmente sustituido con un átomo de cloro o bromo o con un grupo hidroxilo, alcoxilo de hasta 4 átomos de carbono o aciloxi de hasta 4 átomos de carbono y R2 es un átomo de hidrógeno o un grupo alquilo de hasta 4 átomos de carbono o bien R1 está unido a R2 de manera que junto con el átomo de nitrógeno al que están enlazados forman un anillo heteroalicíclico que está opcionalmente sustituido con metilo.
ES457417A 1976-04-02 1977-03-31 Un procedimiento para la preparacion de nuevos aminocromano-les. Expired ES457417A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB13536/76A GB1511187A (en) 1976-04-02 1976-04-02 Chromans
GB3317876 1976-08-10

Publications (1)

Publication Number Publication Date
ES457417A1 true ES457417A1 (es) 1978-07-16

Family

ID=26249838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES457417A Expired ES457417A1 (es) 1976-04-02 1977-03-31 Un procedimiento para la preparacion de nuevos aminocromano-les.

Country Status (14)

Country Link
US (1) US4251537A (es)
JP (1) JPS52122372A (es)
AU (1) AU503934B2 (es)
CA (1) CA1119180A (es)
CH (1) CH632262A5 (es)
DE (2) DE2713670A1 (es)
DK (1) DK147777A (es)
ES (1) ES457417A1 (es)
FR (1) FR2346346A1 (es)
IE (1) IE44977B1 (es)
IL (1) IL51648A (es)
NL (2) NL7703440A (es)
NZ (1) NZ183551A (es)
SE (1) SE7703715L (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0028449B1 (en) 1979-09-28 1983-07-20 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3064286D1 (en) 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0046652B1 (en) * 1980-08-21 1985-05-22 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
US4447622A (en) * 1981-09-22 1984-05-08 Council Of Scientific And Industrial Research Rafi Marg Preparation of l- and d-isomers of dl-3,4-trans-2,2-disubstituted-3,4-diarylchromans and derivatives thereof
ZM7682A1 (en) * 1981-09-25 1983-05-23 Beecham Group Plc Active compounds
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
US4404207A (en) * 1981-11-06 1983-09-13 Riker Laboratories, Inc. Antimicrobial 8-substituted benzo [IJ]quinolizines
EP0091748B1 (en) * 1982-04-08 1986-06-18 Beecham Group Plc Antihypertensive benzopyranols
DE3368057D1 (en) * 1982-05-21 1987-01-15 Beecham Group Plc Pharmaceutically active aminobenzopyrans
GB8308063D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
EP0139992B1 (en) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol derivatives
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
IL88035A0 (en) * 1987-10-27 1989-06-30 American Home Prod Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
DE3823533A1 (de) * 1988-07-12 1990-02-08 Beiersdorf Ag Substituierte 4-heterocyclyl-2h-benzo(b)pyrane, verfahren und 4-hydroxy-3-brom-, 3,4-oxiranyl-3,4-dehydro-2h-benzo(b)pyrane als zwischenprodukte zu ihrer herstellung, sowie sie enthaltende pharmazeutsche praeparate
DE3827532A1 (de) * 1988-08-13 1990-03-01 Hoechst Ag 6-aroyl-substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
US4997846A (en) * 1988-12-09 1991-03-05 Researche Syntex France, S.A. Novel benzopyranylpyrrolinone derivatives
US4908378A (en) * 1989-04-12 1990-03-13 American Home Products Corporation Benzopyran derivatives and antihypertensive use thereof
DE3923839A1 (de) * 1989-07-19 1991-01-31 Beiersdorf Ag Benzopyran-derivate, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans

Also Published As

Publication number Publication date
IE44977B1 (en) 1982-06-02
AU503934B2 (en) 1979-09-27
IL51648A (en) 1982-08-31
US4251537A (en) 1981-02-17
DE2713670A1 (de) 1977-10-06
NL8402722A (nl) 1984-12-03
FR2346346B1 (es) 1980-03-07
CA1119180A (en) 1982-03-02
FR2346346A1 (fr) 1977-10-28
IE44977L (en) 1977-10-02
DK147777A (da) 1977-10-03
IL51648A0 (en) 1977-05-31
DE2760316C3 (de) 1993-12-23
JPS52122372A (en) 1977-10-14
JPS6112910B2 (es) 1986-04-10
DE2760316C2 (es) 1993-12-23
CH632262A5 (de) 1982-09-30
NL7703440A (nl) 1977-10-04
NZ183551A (en) 1978-09-20
AU2387577A (en) 1978-10-12
SE7703715L (sv) 1977-10-03

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