ES424751A1 - Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them - Google Patents

Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them

Info

Publication number
ES424751A1
ES424751A1 ES424751A ES424751A ES424751A1 ES 424751 A1 ES424751 A1 ES 424751A1 ES 424751 A ES424751 A ES 424751A ES 424751 A ES424751 A ES 424751A ES 424751 A1 ES424751 A1 ES 424751A1
Authority
ES
Spain
Prior art keywords
dibenzo
preparation
see formula
general formula
thiepins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424751A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH460573A external-priority patent/CH593970A5/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES424751A1 publication Critical patent/ES424751A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

Procedure for the preparation of dibenzo [b, f] thiepine derivatives of the general formula ** (See formula) ** in which one of the two symbols R1 and R2 or R3 and R4 represents a hydrogen atom and the other represents a chlorine or fluorine atom or a group of methyl, methoxy, methylthio, dimethylsulfamoyl or trifluoromethyl, n represents the number 2 or 3, m represents the number zero or 1, X represents a sulfur or oxygen atom or an imino, (lower alkyl) -imino or methylene group, and R5 and R6 each represent a hydrogen atom or R5 and R6 together represent the grouping ** (See formula) ** characterized by comprising reacting a compound of the general formula ** (See formula) ** in which R1, R2, R3 and R4 have the meaning set out above and Y represents a part group, with a compound of the general formula ** (See formula) ** and, if desired, converting a product obtained into a respective salt. (Machine-translation by Google Translate, not legally binding)
ES424751A 1973-03-30 1974-03-29 Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them Expired ES424751A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH460573A CH593970A5 (en) 1973-03-30 1973-03-30 10-(4-Substd. piperazino) dibenzo (b,f) thiepins - CNS depressants without cataleptic side-effects
CH44874 1974-01-14

Publications (1)

Publication Number Publication Date
ES424751A1 true ES424751A1 (en) 1977-01-01

Family

ID=25684603

Family Applications (2)

Application Number Title Priority Date Filing Date
ES424751A Expired ES424751A1 (en) 1973-03-30 1974-03-29 Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them
ES447120A Expired ES447120A1 (en) 1973-03-30 1976-04-17 PROCEDURE FOR THE PREPARATION OF THE DERIVATIVE OF DIBENZO (B, F) TIEPINA.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES447120A Expired ES447120A1 (en) 1973-03-30 1976-04-17 PROCEDURE FOR THE PREPARATION OF THE DERIVATIVE OF DIBENZO (B, F) TIEPINA.

Country Status (16)

Country Link
JP (1) JPS49135982A (en)
AR (1) AR218600A1 (en)
AT (1) AT344177B (en)
CA (1) CA1024516A (en)
DD (1) DD113545A5 (en)
DE (1) DE2412522A1 (en)
ES (2) ES424751A1 (en)
FR (1) FR2223027B1 (en)
GB (1) GB1464977A (en)
HU (1) HU168402B (en)
IE (1) IE39099B1 (en)
IL (1) IL44427A (en)
LU (1) LU69734A1 (en)
NL (1) NL7404312A (en)
PH (1) PH12737A (en)
PL (1) PL96534B1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH611898A5 (en) * 1975-06-06 1979-06-29 Hoffmann La Roche
CS249455B1 (en) * 1985-01-24 1987-03-12 Miroslav Protiva N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
US4792604A (en) * 1987-03-20 1988-12-20 Gaf Corporation Manufacture of haloalkyl lactams
US5935958A (en) * 1996-07-01 1999-08-10 Schering Corporation Muscarinic antagonists
HUP9904167A3 (en) * 1996-07-01 2000-07-28 Schering Corp 1,4-disubstituted piperazine and piperidine derivatives, their use and pharmaceutical compositions containing the same
SE0301010D0 (en) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (en) 2003-08-21 2009-11-10 استرازينيكا ايه بي Substiuted phenoxacetic as pharmaceutced compunds for treating respiratory diseases such as asthma and copd
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
JP5208510B2 (en) 2004-11-23 2013-06-12 アストラゼネカ・アクチエボラーグ Phenoxyacetic acid derivatives useful for the treatment of respiratory diseases
JP5155171B2 (en) 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ New compounds
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
UA100983C2 (en) 2007-07-05 2013-02-25 Астразенека Аб Biphenyloxypropanoic acid as crth2 modulator and intermediates

Also Published As

Publication number Publication date
IE39099L (en) 1974-09-30
IL44427A0 (en) 1974-06-30
JPS49135982A (en) 1974-12-27
GB1464977A (en) 1977-02-16
AR218600A1 (en) 1980-06-30
AU6582774A (en) 1975-08-21
NL7404312A (en) 1974-10-02
AT344177B (en) 1978-07-10
IE39099B1 (en) 1978-08-02
ES447120A1 (en) 1977-09-16
DD113545A5 (en) 1975-06-12
DE2412522A1 (en) 1974-10-10
FR2223027B1 (en) 1977-05-06
LU69734A1 (en) 1976-02-04
IL44427A (en) 1978-06-15
PH12737A (en) 1979-08-09
FR2223027A1 (en) 1974-10-25
CA1024516A (en) 1978-01-17
HU168402B (en) 1976-04-28
ATA260074A (en) 1977-11-15
PL96534B1 (en) 1977-12-31

Similar Documents

Publication Publication Date Title
ES424751A1 (en) Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them
IE41172L (en) Benzcycloamide derivatives
EP0048763A4 (en) Sulfur-containing acylamino acids.
DE3061175D1 (en) Glucosamine-peptide derivatives, their production and use
ES463803A1 (en) PROCEDURE FOR THE PRODUCTION OF O-ALKYLATED HYDROXYLAMINS.
ES439548A1 (en) 8alpha-substituted ergoline i derivatives
GB1440212A (en) Derivatives of 2-phenoxyacetamido-5-nitrothiazoles
ES419337A1 (en) Process for the preparation of thiazole-sulphenamides
ES438637A1 (en) PROCEDURE FOR PREPARING FLUORENONE DERIVATIVES.
ES423232A1 (en) 2-phenylamino-imidazolines-(2)
ES423699A1 (en) 3-oxyiminomethyl-cephalosporins
ES444389A1 (en) Penicillins their production and their medicinal use
NZ189091A (en) Prostaglandin derivatives
ES432038A2 (en) Imidazole derivatives
JPS5287171A (en) Gamma-pyrone, gamma-pyridone compounds, preparation and medicines consisting of them
ES471125A1 (en) 1-Substituted aminoindolines, process for their production and pharmaceutical compositions containing them.
ES2024332A6 (en) New sulfonamides as antifungal agents.
ES435351A1 (en) 1-(3-phenylpropyl)-4-furoylpiperazine derivatives
ES8406457A1 (en) Piperazine derivatives
ES388464A1 (en) Phenoxyethylamines
ES425197A1 (en) Penicillanic acids their production and their medicinal use
ES427587A1 (en) Procedure for the preparation of 01,3,5-triazapenta-1,4-diens. (Machine-translation by Google Translate, not legally binding)
ES427448A3 (en) Procedure for the preparation of N-tritilimidazoles (Machine-translation by Google Translate, not legally binding)
EP0529100A4 (en) Indolinospirobenzopyran derivative
ES425357A1 (en) A method of preparation of cefem derivatives. (Machine-translation by Google Translate, not legally binding)