ES447120A1 - Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them - Google Patents

Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them

Info

Publication number
ES447120A1
ES447120A1 ES447120A ES447120A ES447120A1 ES 447120 A1 ES447120 A1 ES 447120A1 ES 447120 A ES447120 A ES 447120A ES 447120 A ES447120 A ES 447120A ES 447120 A1 ES447120 A1 ES 447120A1
Authority
ES
Spain
Prior art keywords
dibenzo
preparation
see formula
general formula
thiepins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES447120A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH460573A external-priority patent/CH593970A5/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES447120A1 publication Critical patent/ES447120A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

Abstract

Procedure for the preparation of dibenzo [b, f] thiepine derivatives of the general formula **(See formula)** in which one of the symbols R1 and R2 or R3 and R4 represents a hydrogen atom and the other represents a chlorine or fluorine atom or a group of methyl, methoxy, methylthio, dimethylsulfamoyl or trifluoromethyl, n represents the number 2 or 3, m represents the number zero or 1, X represents a sulfur or oxygen atom or an imino, (lower alkyl) -imino or methylene group, and R5 and R6 each represent a hydrogen atom R5 and R6 together represent the grouping **(See formula)** characterized by comprising reacting a compound of the general formula **(See formula)** in which R1, R2, R3 and R4 have the meaning indicated above, with a compound of the general formula **(See formula)** in which Y, n, m, X, R5 and R6 have the meaning indicated above, and, if desired, convert a product obtained into a respective salt. (Machine-translation by Google Translate, not legally binding)
ES447120A 1973-03-30 1976-04-17 Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them Expired ES447120A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH460573A CH593970A5 (en) 1973-03-30 1973-03-30 10-(4-Substd. piperazino) dibenzo (b,f) thiepins - CNS depressants without cataleptic side-effects
CH44874 1974-01-14

Publications (1)

Publication Number Publication Date
ES447120A1 true ES447120A1 (en) 1977-09-16

Family

ID=25684603

Family Applications (2)

Application Number Title Priority Date Filing Date
ES424751A Expired ES424751A1 (en) 1973-03-30 1974-03-29 Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them
ES447120A Expired ES447120A1 (en) 1973-03-30 1976-04-17 Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES424751A Expired ES424751A1 (en) 1973-03-30 1974-03-29 Piperazinyl -dibenzo b,f thiepins methods for their preparation and compositions containing them

Country Status (16)

Country Link
JP (1) JPS49135982A (en)
AR (1) AR218600A1 (en)
AT (1) AT344177B (en)
CA (1) CA1024516A (en)
DD (1) DD113545A5 (en)
DE (1) DE2412522A1 (en)
ES (2) ES424751A1 (en)
FR (1) FR2223027B1 (en)
GB (1) GB1464977A (en)
HU (1) HU168402B (en)
IE (1) IE39099B1 (en)
IL (1) IL44427A (en)
LU (1) LU69734A1 (en)
NL (1) NL7404312A (en)
PH (1) PH12737A (en)
PL (1) PL96534B1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH611898A5 (en) * 1975-06-06 1979-06-29 Hoffmann La Roche
CS249455B1 (en) * 1985-01-24 1987-03-12 Miroslav Protiva N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
US4792604A (en) * 1987-03-20 1988-12-20 Gaf Corporation Manufacture of haloalkyl lactams
US5935958A (en) * 1996-07-01 1999-08-10 Schering Corporation Muscarinic antagonists
DE69715865T2 (en) * 1996-07-01 2003-08-07 Schering Corp Muscarinic Antagonists
SE0301010D0 (en) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (en) 2003-08-21 2009-11-10 استرازينيكا ايه بي Substiuted phenoxacetic as pharmaceutced compunds for treating respiratory diseases such as asthma and copd
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
EP1817282B1 (en) 2004-11-23 2011-07-20 AstraZeneca AB Phenoxyacetic acid derivatives useful for treating respiratory diseases
US8148572B2 (en) 2005-10-06 2012-04-03 Astrazeneca Ab Compounds
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
UA100983C2 (en) 2007-07-05 2013-02-25 Астразенека Аб Biphenyloxypropanoic acid as crth2 modulator and intermediates

Also Published As

Publication number Publication date
ATA260074A (en) 1977-11-15
IL44427A0 (en) 1974-06-30
IE39099B1 (en) 1978-08-02
GB1464977A (en) 1977-02-16
IE39099L (en) 1974-09-30
FR2223027A1 (en) 1974-10-25
NL7404312A (en) 1974-10-02
AU6582774A (en) 1975-08-21
LU69734A1 (en) 1976-02-04
HU168402B (en) 1976-04-28
IL44427A (en) 1978-06-15
DE2412522A1 (en) 1974-10-10
FR2223027B1 (en) 1977-05-06
AT344177B (en) 1978-07-10
ES424751A1 (en) 1977-01-01
AR218600A1 (en) 1980-06-30
PH12737A (en) 1979-08-09
PL96534B1 (en) 1977-12-31
CA1024516A (en) 1978-01-17
DD113545A5 (en) 1975-06-12
JPS49135982A (en) 1974-12-27

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