IE39099L - Heterocycle - substituted dibenzothiepins. - Google Patents

Heterocycle - substituted dibenzothiepins.

Info

Publication number
IE39099L
IE39099L IE740644A IE64474A IE39099L IE 39099 L IE39099 L IE 39099L IE 740644 A IE740644 A IE 740644A IE 64474 A IE64474 A IE 64474A IE 39099 L IE39099 L IE 39099L
Authority
IE
Ireland
Prior art keywords
compound
compounds
reacting
vii
substituted
Prior art date
Application number
IE740644A
Other versions
IE39099B1 (en
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH460573A external-priority patent/CH593970A5/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of IE39099L publication Critical patent/IE39099L/en
Publication of IE39099B1 publication Critical patent/IE39099B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14—[b,f]-condensed

Abstract

1464977 Piperazinyl-dibenz[b,t]thiepin derivatives F HOFFMANN-LA ROCHE & CO AG 29 March 1974 [30. March 1973 14 Jan 1974] 14018/74 Heading C2C Novel compounds I in which one of each pair R 1 and R 2 or R 3 and R 4 represents H and the other Cl, Br, Me,. MeS, Me 2 NSO 2 or CF 2 , n is 2 or 3, m is 0 or 1, X is O, S, optionally C 1-7 alkylated-imino, or CH 2 , R 5 and R 6 are hydrogen or together with the C- atoms to which they are attached form a phenyl ring and the dotted line represents an optional bond are prepared by (1) reacting a compound II in which Y is a leaving atom or group with a compound III to form a 10,11-dihydro derivative (2) reacting a compound VII with a compound III and if desired hydrogenating the compound formed (3) reacting a compound V with a compound VI to form a 10,11-dihydro compound. Compounds VII (R 1 or R 2 =Me, MeO, Cl, CF 3 and R 3 or R 4 = F, Cl, MeO) are prepared by reacting an R 1 or R 2 substituted 2-iodobenzoic acid with an R 3 or R 4 substituted thiophenol in the presence of copper converting the carboxyl group to carboxylmethyl by the standard homologation procedure and cyclizing the acid under acidic conditions. Compounds VII are reduced to the alcohol which is chlorinated to form compounds V (Y = Cl). Compounds I are CNS depressants and have neuroleptic properties and form with a carrier a pharmaceutical composition which may be administered orally or parenterally. [GB1464977A]
IE644/74A 1973-03-30 1974-03-25 Piperazinyl-dibenzo (b-f) thiepins, methods for their preparation and compositions containing them IE39099B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH460573A CH593970A5 (en) 1973-03-30 1973-03-30 10-(4-Substd. piperazino) dibenzo (b,f) thiepins - CNS depressants without cataleptic side-effects
CH44874 1974-01-14

Publications (2)

Publication Number Publication Date
IE39099L true IE39099L (en) 1974-09-30
IE39099B1 IE39099B1 (en) 1978-08-02

Family

ID=25684603

Family Applications (1)

Application Number Title Priority Date Filing Date
IE644/74A IE39099B1 (en) 1973-03-30 1974-03-25 Piperazinyl-dibenzo (b-f) thiepins, methods for their preparation and compositions containing them

Country Status (16)

Country Link
JP (1) JPS49135982A (en)
AR (1) AR218600A1 (en)
AT (1) AT344177B (en)
CA (1) CA1024516A (en)
DD (1) DD113545A5 (en)
DE (1) DE2412522A1 (en)
ES (2) ES424751A1 (en)
FR (1) FR2223027B1 (en)
GB (1) GB1464977A (en)
HU (1) HU168402B (en)
IE (1) IE39099B1 (en)
IL (1) IL44427A (en)
LU (1) LU69734A1 (en)
NL (1) NL7404312A (en)
PH (1) PH12737A (en)
PL (1) PL96534B1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH611898A5 (en) * 1975-06-06 1979-06-29 Hoffmann La Roche
CS249455B1 (en) * 1985-01-24 1987-03-12 Miroslav Protiva N-substituted 2-chloro-7-fluoro-10-piperazino-10,11-dihydrodibenzo(b,f)thiepines and their salts and method of their preparation
US4792604A (en) * 1987-03-20 1988-12-20 Gaf Corporation Manufacture of haloalkyl lactams
US5935958A (en) * 1996-07-01 1999-08-10 Schering Corporation Muscarinic antagonists
AU717431B2 (en) * 1996-07-01 2000-03-23 Schering Corporation Muscarinic antagonists
SE0301010D0 (en) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (en) 2003-08-21 2009-11-10 استرازينيكا ايه بي Substiuted phenoxacetic as pharmaceutced compunds for treating respiratory diseases such as asthma and copd
GB0415320D0 (en) * 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
EP1817282B1 (en) 2004-11-23 2011-07-20 AstraZeneca AB Phenoxyacetic acid derivatives useful for treating respiratory diseases
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
US8148572B2 (en) 2005-10-06 2012-04-03 Astrazeneca Ab Compounds
UA100983C2 (en) 2007-07-05 2013-02-25 Астразенека Аб Biphenyloxypropanoic acid as crth2 modulator and intermediates

Also Published As

Publication number Publication date
FR2223027A1 (en) 1974-10-25
LU69734A1 (en) 1976-02-04
FR2223027B1 (en) 1977-05-06
ES447120A1 (en) 1977-09-16
DD113545A5 (en) 1975-06-12
AR218600A1 (en) 1980-06-30
HU168402B (en) 1976-04-28
IE39099B1 (en) 1978-08-02
IL44427A (en) 1978-06-15
AU6582774A (en) 1975-08-21
JPS49135982A (en) 1974-12-27
DE2412522A1 (en) 1974-10-10
PL96534B1 (en) 1977-12-31
CA1024516A (en) 1978-01-17
NL7404312A (en) 1974-10-02
AT344177B (en) 1978-07-10
ES424751A1 (en) 1977-01-01
GB1464977A (en) 1977-02-16
ATA260074A (en) 1977-11-15
PH12737A (en) 1979-08-09
IL44427A0 (en) 1974-06-30

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