ES439548A1 - 8alpha-substituted ergoline i derivatives - Google Patents

8alpha-substituted ergoline i derivatives

Info

Publication number
ES439548A1
ES439548A1 ES439548A ES439548A ES439548A1 ES 439548 A1 ES439548 A1 ES 439548A1 ES 439548 A ES439548 A ES 439548A ES 439548 A ES439548 A ES 439548A ES 439548 A1 ES439548 A1 ES 439548A1
Authority
ES
Spain
Prior art keywords
carbon atoms
formula
previously indicated
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES439548A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH998374A external-priority patent/CH605936A5/en
Priority claimed from CH1103174A external-priority patent/CH605938A5/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES439548A1 publication Critical patent/ES439548A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing ergoline derivatives, of formula I, <br/> <br/> ** (See formula) ** where <br/> <br/> X is hydrogen, chlorine or bromine, <br/> <br/> R1 is methyl or ethyl, and R2 is CH2-CN, or a group NR3R4, where R3 is hydrogen or alkyl of 1 to 4 carbon atoms, and is formyl, alkanoyl of 2 to 5 carbon atoms in its entirety, alkoxycarbonyl of 2 to 5 atoms carbon in all of it, mono- to trihalogenalkoxycarbonyl of 3 to 5 carbon atoms in all of it, the alkoxy radical thereof being replaced by halogen in a position other than the α relative to oxygen, or the radical SO2R5, where R5 is alkyl of 1 to 4 carbon atoms, mono- to trihalogenalkyl of 1 to 4 carbon atoms, phenyl, pyridyl, phenyl monosubstituted by halogen <br/> <br/> or alkoxy of 1 to 4 carbon atoms, or a group NR6R7, where each of <br/> <br/> R6 and R7, independently, is hydrogen or C 1-4 -alkyl, or <br/> <br/> R6 and R7 together are one of the groups (CH2) not (Ch2) 2-A- (CH2) 2, where n is a number from 3 to 7, and <br/> <br/> A is oxygen, sulfur, or nitrogen substituted by alkyl of 1 to 4 carbon atoms or phenyl, <br/> <br/> characterized in that <br/> <br/> a) a compound of formula Ia is produced, ** ( See formula) ** where X and R1 have the previously indicated meanings, exchanging the radical Z for a cyano group in a compound of formula II, <br / > <br/> ** (See formula) ** where Z is a radical capable of being interchanged in a nucleophilic substitution reaction, and X and R1 have the previously indicated meanings, <br/> <br/> or b) a compound of formula Ib is produced, <br/><br /> ** (See formula) ** where X, R1, R3 and R4 have the previously indicated meanings, acylating a compound of formula III, where X, R1 and R3 have the previously indicated meanings, with a reactive functional derivative of an acid R4OH, where R4 has the previously indicated meaning. (Machine-translation by Google Translate, not legally binding)
ES439548A 1974-07-19 1975-07-17 8alpha-substituted ergoline i derivatives Expired ES439548A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH998374A CH605936A5 (en) 1974-07-19 1974-07-19 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs
CH1103174A CH605938A5 (en) 1974-08-13 1974-08-13 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs

Publications (1)

Publication Number Publication Date
ES439548A1 true ES439548A1 (en) 1977-06-16

Family

ID=25705648

Family Applications (1)

Application Number Title Priority Date Filing Date
ES439548A Expired ES439548A1 (en) 1974-07-19 1975-07-17 8alpha-substituted ergoline i derivatives

Country Status (17)

Country Link
JP (1) JPS5134199A (en)
AU (1) AU505314B2 (en)
CA (1) CA1073452A (en)
DD (1) DD118635A5 (en)
DE (1) DE2530577A1 (en)
DK (2) DK143902C (en)
ES (1) ES439548A1 (en)
FI (1) FI61188C (en)
FR (1) FR2282889A1 (en)
GB (3) GB1517973A (en)
HK (2) HK56880A (en)
IE (1) IE41426B1 (en)
IL (1) IL47735A (en)
MY (2) MY8100217A (en)
NL (1) NL7508416A (en)
NO (1) NO752493L (en)
PH (1) PH16594A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1573621A (en) * 1976-01-02 1980-08-28 Sandoz Ltd Acylated 6-methyl-8a-amino-ergoline i compounds
DE2656344A1 (en) * 1975-12-23 1977-07-07 Sandoz Ag ERGOLIN DERIVATIVES, THEIR USE AND MANUFACTURING
IT1064473B (en) * 1976-11-24 1985-02-18 Simes 8-BETA-AMINOMETHYLERGOLINE DERIVATIVES ON SULFAMOIL
BE889713A (en) * 1980-07-25 1982-01-25 Sandoz Sa NEW ERGOLIN DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
DE3127845A1 (en) * 1980-07-25 1982-04-22 Sandoz-Patent-GmbH, 7850 Lörrach ERGOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE THERAPEUTIC TREATMENT
CH644606A5 (en) * 1980-09-23 1984-08-15 Sandoz Ag METHOD FOR ISOMERIZING 9,10-DIHYDROLYSE ENERGY DERIVATIVES.
DE3101535A1 (en) * 1981-01-14 1982-08-12 Schering Ag, 1000 Berlin Und 4619 Bergkamen NEW (2-HALOGEN-ERGOLINYL) -N'.N'-DIETHYL-UREA DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A MEDICINAL PRODUCT
JPS58174081A (en) * 1982-04-05 1983-10-13 Mitsubishi Heavy Ind Ltd Ventilator for engine room of ship
HU197569B (en) * 1984-01-12 1989-04-28 Sandoz Ag Process for producing 8alpha-acylaminoergoline derivatives and pharmaceuticals comprising such compounds
HU195810B (en) * 1984-12-24 1988-07-28 Sandoz Ag Process for preparing new 8alpha-acyl-amino-ergoline derivatives and pharmaceutical compositions containing such compounds
NL8700046A (en) * 1986-01-24 1987-08-17 Sandoz Ag 8 ALFA-ACYLAMINOERGOLINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.
AT392945B (en) * 1988-06-27 1991-07-10 Gerhard Mader Ges M B H Ing STORAGE AND TRANSPORTATION CONTAINERS FOR Bulk goods and loose materials
DE4033496A1 (en) * 1990-10-20 1992-04-23 Sandoz Ag NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND USE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3218323A (en) * 1965-11-16 Esters of i,g-dimethyl-b-ergolenyl carbamic acid
FR1360618A (en) * 1963-06-17 1964-05-08 Sandoz Sa New urethanes of the lysergic series and their preparation
BE712054A (en) * 1967-03-16 1968-07-15
NL6818658A (en) * 1968-01-18 1969-07-22
AR206772A1 (en) * 1972-07-21 1976-08-23 Lilly Co Eli PROCEDURE TO PREPARE A NEW D-2-HALO-6-METHYL-8-CYANE (CARBOXAMIDE) METHYL ERGOLINE

Also Published As

Publication number Publication date
DD118635A5 (en) 1976-03-12
MY8100215A (en) 1981-12-31
HK56880A (en) 1980-10-16
FR2282889A1 (en) 1976-03-26
FI61188C (en) 1982-06-10
MY8100217A (en) 1981-12-31
FR2282889B1 (en) 1979-08-10
DE2530577A1 (en) 1976-01-29
GB1517971A (en) 1978-07-19
DE2530577C2 (en) 1990-11-08
FI752011A (en) 1976-01-20
FI61188B (en) 1982-02-26
HK56980A (en) 1980-10-16
AU505314B2 (en) 1979-11-15
CA1073452A (en) 1980-03-11
DK143902C (en) 1982-04-13
IE41426L (en) 1976-01-19
IE41426B1 (en) 1980-01-02
JPS5134199A (en) 1976-03-23
DK145542B (en) 1982-12-06
NO752493L (en) 1976-01-20
DK313175A (en) 1976-01-20
IL47735A (en) 1979-11-30
PH16594A (en) 1983-11-22
GB1517972A (en) 1978-07-19
AU8316275A (en) 1977-01-20
GB1517973A (en) 1978-07-19
DK143902B (en) 1981-10-26
IL47735A0 (en) 1975-10-15
DK145542C (en) 1983-05-02
NL7508416A (en) 1976-01-21
DK298980A (en) 1980-07-10

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19930217