ES451113A1 - Improvement of organic compound - Google Patents

Improvement of organic compound

Info

Publication number
ES451113A1
ES451113A1 ES451113A ES451113A ES451113A1 ES 451113 A1 ES451113 A1 ES 451113A1 ES 451113 A ES451113 A ES 451113A ES 451113 A ES451113 A ES 451113A ES 451113 A1 ES451113 A1 ES 451113A1
Authority
ES
Spain
Prior art keywords
carbon atoms
group containing
formula
nitrogen atom
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES451113A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES451113A1 publication Critical patent/ES451113A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedure for preparing oxamic acid derivatives of formula I **(See formula)** where it's hydrogen, chlorine or bromine, R2 is hydrogen or an alkyl group containing 1 to 4 carbon atoms, R3 is hydrogen, an alkyl group containing 1 to 4 carbon atoms, an alkenyl or alkynyl group containing 3 to 5 carbon atoms, the multiple bond of which is not adjacent to the nitrogen atom, a cycloalkyl group containing 5 or 6 carbon atoms carbon or a hydroxyalkyl group containing 2 to 4 carbon atoms, the hydroxy group of which is separated from the nitrogen atom by at least 2 carbon atoms, R4 is an alkyl group containing 1 to 4 carbon atoms, an alkenyl or alkynyl group containing 3 to 5 carbon atoms, the multiple bond of which is not adjacent to the nitrogen atom, a cycloalkyl group containing 5 or 6 carbon atoms, a hydroxyalkyl group containing 2 to 4 carbon atoms, the hydroxy group of which is separated from the nitrogen atom by at least 2 carbon atoms or, in the case of hydrogen or an alkyl group containing 1 to 4 carbon atoms, it also means a phenyl or phenylalkyl group whose alkylene chain contains 1 to 4 carbon atoms and which may be mono- or disubstituted in the phenyl ring by fluorine, chlorine, bromine or an alkyl or alkoxy group containing 1 to 4 carbon atoms, or a pyridinyl group or a pyrimidinyl group optionally substituted by 1 or 2 methyl groups, or R3 and R4 together with the nitrogen atom to which they are linked, signify a group (see formula) where X is -CH2-, -0- or a bond, and the salts of the acids of formula I, characterized in that they are reacted reactive acid derivatives of sulfonic acids of formula II **(See formula)** where it has the previously indicated meaning and R2 is alkyl of 1 to 4 carbon atoms, with amines of formula III **(See formula)** wherein R3 and R4 have the previously indicated meanings, preferably in the presence of an inert organic solvent, at temperatures between 0 and 100ºC, preferably around 10-25ºC, and the resulting compounds of formula Ia **(See formula)** Where R1, R3, R4 and R2'have the previously indicated meanings, they are optionally hydrolyzed to provide compounds of formula Ib **(See formula)** wherein R1, R3 and R4 have the previously indicated meanings, preferably in the presence of dilute bases, at ambient to boiling temperatures of the reaction mixture and optionally in the presence of an inert organic solvent. (Machine-translation by Google Translate, not legally binding)
ES451113A 1975-09-02 1976-08-31 Improvement of organic compound Expired ES451113A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1136775 1975-09-02
CH1136675 1975-09-02
CH1419475 1975-11-04
CH21876 1976-01-09

Publications (1)

Publication Number Publication Date
ES451113A1 true ES451113A1 (en) 1977-11-16

Family

ID=27427797

Family Applications (1)

Application Number Title Priority Date Filing Date
ES451113A Expired ES451113A1 (en) 1975-09-02 1976-08-31 Improvement of organic compound

Country Status (11)

Country Link
JP (1) JPS5233645A (en)
AU (1) AU1737376A (en)
DE (1) DE2637882A1 (en)
DK (1) DK380176A (en)
ES (1) ES451113A1 (en)
FI (1) FI762419A (en)
FR (1) FR2322592A1 (en)
IL (1) IL50390A0 (en)
NO (1) NO762922L (en)
PT (1) PT65538B (en)
SE (1) SE7609494L (en)

Also Published As

Publication number Publication date
IL50390A0 (en) 1976-10-31
FR2322592B1 (en) 1978-11-17
AU1737376A (en) 1978-03-09
FI762419A (en) 1977-03-03
DK380176A (en) 1977-03-03
JPS5233645A (en) 1977-03-14
DE2637882A1 (en) 1977-03-03
FR2322592A1 (en) 1977-04-01
NO762922L (en) 1977-03-03
SE7609494L (en) 1977-03-03
PT65538A (en) 1976-09-01
PT65538B (en) 1978-05-10

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