ES418014A1 - Un procedimiento para preparar derivados de benzodiacepina. - Google Patents

Un procedimiento para preparar derivados de benzodiacepina.

Info

Publication number
ES418014A1
ES418014A1 ES418014A ES418014A ES418014A1 ES 418014 A1 ES418014 A1 ES 418014A1 ES 418014 A ES418014 A ES 418014A ES 418014 A ES418014 A ES 418014A ES 418014 A1 ES418014 A1 ES 418014A1
Authority
ES
Spain
Prior art keywords
general formula
benzodiazepine derivatives
procedure
formula
indicated above
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES418014A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES418014A1 publication Critical patent/ES418014A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/28Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/30Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES418014A 1972-08-21 1973-08-20 Un procedimiento para preparar derivados de benzodiacepina. Expired ES418014A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28221772A 1972-08-21 1972-08-21
US35981473A 1973-05-14 1973-05-14

Publications (1)

Publication Number Publication Date
ES418014A1 true ES418014A1 (es) 1976-03-16

Family

ID=26961312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES418014A Expired ES418014A1 (es) 1972-08-21 1973-08-20 Un procedimiento para preparar derivados de benzodiacepina.

Country Status (24)

Country Link
JP (1) JPS5911589B2 (et)
AR (1) AR198108A1 (et)
AT (1) AT341527B (et)
AU (1) AU472777B2 (et)
CA (1) CA1012535A (et)
CH (1) CH578544A5 (et)
DD (1) DD107040A5 (et)
DE (1) DE2340159A1 (et)
DK (1) DK155326C (et)
ES (1) ES418014A1 (et)
FI (1) FI57939C (et)
FR (1) FR2197003B1 (et)
GB (1) GB1392681A (et)
HU (1) HU170153B (et)
IE (1) IE38091B1 (et)
IL (1) IL42947A (et)
LU (1) LU68269A1 (et)
NL (1) NL179582C (et)
NO (1) NO139481C (et)
PH (1) PH13640A (et)
PL (1) PL99162B1 (et)
SE (1) SE408302B (et)
SU (1) SU550980A3 (et)
YU (1) YU219873A (et)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5334792A (en) * 1976-09-13 1978-03-31 Scherico Ltd Production of 1*44 benzodiazepines and 1*44 benzodiazepinee22ones
CN113149915B (zh) * 2021-03-01 2024-03-15 中国科学院成都有机化学有限公司 一种合成氯硝西泮化合物的方法
CN116023342B (zh) * 2021-10-26 2024-06-25 江苏昱林生物科技有限公司 一种高纯度氯硝西泮的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1136709B (de) * 1959-12-10 1962-09-20 Hoffmann La Roche Verfahren zur Herstellung von 2-Oxo-1, 2-dihydro-1, 4-benzodiazepinen
CH537393A (de) * 1969-10-16 1973-05-31 Hoffmann La Roche Verfahren zur Herstellung von 1,4-Benzodiazepin-derivaten
BE785962A (fr) * 1971-07-08 1973-01-08 Hoffmann La Roche Procede pour la preparation de derives de benzodiazepine

Also Published As

Publication number Publication date
GB1392681A (en) 1975-04-30
FI57939B (fi) 1980-07-31
FR2197003B1 (et) 1978-01-13
SE408302B (sv) 1979-06-05
YU219873A (en) 1982-06-30
DK155326C (da) 1989-08-14
AR198108A1 (es) 1974-05-31
DE2340159C2 (et) 1989-01-19
AU472777B2 (en) 1976-06-03
JPS5911589B2 (ja) 1984-03-16
LU68269A1 (et) 1975-05-21
FR2197003A1 (et) 1974-03-22
NL7311507A (et) 1974-02-25
ATA720773A (de) 1977-06-15
IE38091B1 (en) 1977-12-21
FI57939C (fi) 1980-11-10
PH13640A (en) 1980-08-18
NL179582C (nl) 1986-10-01
IL42947A0 (en) 1973-11-28
NO139481C (no) 1979-03-21
CA1012535A (en) 1977-06-21
HU170153B (et) 1977-04-28
IL42947A (en) 1977-01-31
AU5918073A (en) 1975-02-13
SU550980A3 (ru) 1977-03-15
DK155326B (da) 1989-03-28
DE2340159A1 (de) 1974-03-07
IE38091L (en) 1974-02-21
AT341527B (de) 1978-02-10
NO139481B (no) 1978-12-11
JPS4956992A (et) 1974-06-03
PL99162B1 (pl) 1978-06-30
DD107040A5 (et) 1974-07-12
CH578544A5 (et) 1976-08-13
NL179582B (nl) 1986-05-01

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