ES408565A1 - Procedimiento para la preparacion de diaminas ciclicas di- sustituidas en n, n. - Google Patents
Procedimiento para la preparacion de diaminas ciclicas di- sustituidas en n, n.Info
- Publication number
- ES408565A1 ES408565A1 ES408565A ES408565A ES408565A1 ES 408565 A1 ES408565 A1 ES 408565A1 ES 408565 A ES408565 A ES 408565A ES 408565 A ES408565 A ES 408565A ES 408565 A1 ES408565 A1 ES 408565A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- group
- alkyl groups
- groups
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Cyclic diamine Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000001424 substituent group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 238000006467 substitution reaction Methods 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
- Quinoline Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2157424A DE2157424C3 (de) | 1971-11-19 | 1971-11-19 | Therapeutisch wirksame N5N'disubstituierte cyclische Diamine und Verfahren zu deren Herstellung |
| DE2240665A DE2240665C2 (de) | 1971-11-19 | 1972-08-18 | N,N'disubstituierte cyclische Diamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES408565A1 true ES408565A1 (es) | 1975-11-01 |
Family
ID=25762040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES408565A Expired ES408565A1 (es) | 1971-11-19 | 1972-11-14 | Procedimiento para la preparacion de diaminas ciclicas di- sustituidas en n, n. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4374990A (forum.php) |
| JP (4) | JPS5523831B2 (forum.php) |
| AT (1) | AT327203B (forum.php) |
| BE (1) | BE791501A (forum.php) |
| CA (1) | CA1025866A (forum.php) |
| CH (4) | CH613202A5 (forum.php) |
| DE (2) | DE2157424C3 (forum.php) |
| ES (1) | ES408565A1 (forum.php) |
| FR (1) | FR2160611B1 (forum.php) |
| GB (1) | GB1407854A (forum.php) |
| NL (1) | NL170147C (forum.php) |
| SE (1) | SE408423B (forum.php) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791501A (fr) * | 1971-11-19 | 1973-05-17 | Albert Ag Chem Werke | Diamines cycliques n,n'-disubstituees et leur procede de preparation |
| GB1382602A (en) * | 1972-06-01 | 1975-02-05 | Labaz | Benzodioxan compounds and process for preparing the same |
| AR207031A1 (es) * | 1974-03-06 | 1976-09-09 | Kyorin Seiyaku Kk | Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina |
| DE2757532A1 (de) * | 1977-12-23 | 1979-07-05 | Hoechst Ag | N,n'-disubstituiertes cyclisches diamin und verfahren zu dessen herstellung |
| US4593102A (en) * | 1984-04-10 | 1986-06-03 | A. H. Robins Company, Inc. | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position |
| IT1176613B (it) * | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
| DE3669876D1 (de) * | 1985-05-13 | 1990-05-03 | Kuraray Co | 3,4-dihydrobenzopyranderivate. |
| DE3529994A1 (de) * | 1985-08-22 | 1987-02-26 | Hoechst Ag | Indolinonderivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung |
| JP2573195B2 (ja) * | 1986-09-30 | 1997-01-22 | エーザイ株式会社 | 環状アミン誘導体 |
| US4937246A (en) * | 1987-11-25 | 1990-06-26 | Takeda Chemical Industries, Ltd. | PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof |
| JPH01217875A (ja) * | 1988-02-24 | 1989-08-31 | Matsushita Electric Works Ltd | 配線ダクト用プラグ |
| US4997836A (en) * | 1988-11-11 | 1991-03-05 | Takeda Chemical Industries, Ltd. | Trisubstituted piperazine compounds, their production and use |
| EP0385043A1 (en) * | 1989-02-28 | 1990-09-05 | Fabrica Espanola De Productos Quimicos Y Farmaceuticos, S.A. (Faes) | New derivatives of 4-substituted piperazines |
| US5739132A (en) * | 1992-07-02 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Pyridazinone derivatives and processes for preparing the same |
| SE9202266D0 (sv) * | 1992-07-31 | 1992-07-31 | Kabi Pharmacia Ab | Novel piperazine carboxamides |
| DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
| FR2724656B1 (fr) * | 1994-09-15 | 1996-12-13 | Adir | Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6395738B1 (en) * | 1997-10-01 | 2002-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Benzofuran derivatives |
| AUPP818099A0 (en) | 1999-01-14 | 1999-02-11 | Fujisawa Pharmaceutical Co., Ltd. | New n-containing heterocyclic compounds |
| US6541477B2 (en) * | 1999-08-27 | 2003-04-01 | Scios, Inc. | Inhibitors of p38-a kinase |
| EP1257544B1 (en) * | 2000-02-11 | 2012-07-25 | Vertex Pharmaceuticals Incorporated | Piperazine and piperidine derivatives for treatment or prevention of neuronal damage |
| DE10035908A1 (de) * | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
| CA2440438C (en) * | 2001-03-09 | 2011-05-03 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds |
| CN1703401A (zh) | 2001-05-22 | 2005-11-30 | 神经原公司 | 黑色素浓集激素受体的配体:取代的1－苄基－4－芳基哌嗪类似物 |
| US20040204477A1 (en) * | 2001-07-09 | 2004-10-14 | Juergen Moll | Interaction inhibitors of tcf-4 with beta-catenin |
| US7037913B2 (en) * | 2002-05-01 | 2006-05-02 | Bristol-Myers Squibb Company | Bicyclo 4.4.0 antiviral derivatives |
| WO2003101871A1 (fr) * | 2002-06-04 | 2003-12-11 | Canon Kabushiki Kaisha | Procede de detection d'alimentation en double de feuilles et dispositif servant a detecter l'alimentation en double de feuilles |
| BR0312294A (pt) * | 2002-06-29 | 2005-04-12 | Zentaris Gmbh | Arilcarbonil piperazinas e hteroarilcarbonilpiperazinas e o uso das mesmas para tratamento de doenças benignas e malignas |
| US20040034019A1 (en) * | 2002-08-08 | 2004-02-19 | Ronald Tomlinson | Piperazine and piperidine derivatives |
| KR20050033662A (ko) | 2002-09-06 | 2005-04-12 | 얀센 파마슈티카 엔.브이. | 헤테로사이클릭 화합물 |
| US20040127395A1 (en) * | 2002-09-06 | 2004-07-01 | Desai Pragnya J. | Use of histamine H4 receptor modulators for the treatment of allergy and asthma |
| SE0400441D0 (sv) * | 2004-02-25 | 2004-02-25 | Active Biotech Ab | Novel Benzofurans and Indols |
| US20090018118A1 (en) * | 2005-12-29 | 2009-01-15 | Uros Urleb | Heterocyclic compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3037981A (en) * | 1959-03-23 | 1962-06-05 | Miles Lab | Phenyltetrahydropyranylpiperazines |
| FR1369991A (fr) * | 1963-04-05 | 1964-08-21 | Lipha | Nouvelles carboxamides-3 hydroxy-4 coumarines et leurs procédés de préparation |
| US3291798A (en) * | 1964-02-25 | 1966-12-13 | Upjohn Co | Hydroquinones, lower alkanoyl derivatives thereof and processes for their production |
| DE1545786A1 (de) * | 1965-01-27 | 1969-12-11 | Hoechst Ag | Verfahren zur Herstellung von Carbonsaeure-N-methylpiperaziden |
| US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
| US3472856A (en) * | 1967-05-29 | 1969-10-14 | Sterling Drug Inc | 1-((thianaphthenyl)-lower-alkyl)-4-substituted-piperazines |
| US3637705A (en) * | 1968-10-01 | 1972-01-25 | Abbott Lab | N-3 4-dihalo phenyl piperazines |
| US3646047A (en) * | 1970-02-02 | 1972-02-29 | American Cyanamid Co | Certain benzo(b)thiophene-2-carboxamide derivatives |
| BE791501A (fr) * | 1971-11-19 | 1973-05-17 | Albert Ag Chem Werke | Diamines cycliques n,n'-disubstituees et leur procede de preparation |
| US4115569A (en) * | 1971-11-19 | 1978-09-19 | Hoechst Aktiengesellschaft | Cyclic diamine derivatives |
| US3865828A (en) * | 1972-03-22 | 1975-02-11 | Egyt Gyogyszervegyeszeti Gyar | Pyridine derivatives having antidepressant activity |
| GB1428186A (en) * | 1972-06-21 | 1976-03-17 | Fujisawa Pharmaceutical Co | Chromone derivatives |
| AR207031A1 (es) * | 1974-03-06 | 1976-09-09 | Kyorin Seiyaku Kk | Procedimiento para preparacion de nuevos derivados de 1-(3-fenilpropil)-4-furoilpiperacina |
| DE2555290A1 (de) * | 1975-12-09 | 1977-06-16 | Boehringer Mannheim Gmbh | Neue benzopyron-derivate und verfahren zu ihrer herstellung |
| US4123529A (en) * | 1976-04-23 | 1978-10-31 | Lilly Industries Limited | Phenylpiperazine derivatives |
| DE2757532A1 (de) * | 1977-12-23 | 1979-07-05 | Hoechst Ag | N,n'-disubstituiertes cyclisches diamin und verfahren zu dessen herstellung |
| NO154582C (no) * | 1978-10-20 | 1986-11-05 | Ferrosan Ab | Analogifremgangsmaate for fremstilling av terapeutisk aktive difenyl-dibutylpiperazinkarboksamider. |
-
0
- BE BE791501D patent/BE791501A/xx not_active IP Right Cessation
-
1971
- 1971-11-19 DE DE2157424A patent/DE2157424C3/de not_active Expired
-
1972
- 1972-08-18 DE DE2240665A patent/DE2240665C2/de not_active Expired
- 1972-11-14 NL NLAANVRAGE7215416,A patent/NL170147C/xx not_active IP Right Cessation
- 1972-11-14 ES ES408565A patent/ES408565A1/es not_active Expired
- 1972-11-17 AT AT981272A patent/AT327203B/de not_active IP Right Cessation
- 1972-11-17 FR FR7240924A patent/FR2160611B1/fr not_active Expired
- 1972-11-17 CH CH74676A patent/CH613202A5/xx not_active IP Right Cessation
- 1972-11-17 SE SE7215027A patent/SE408423B/xx unknown
- 1972-11-17 CA CA156,801A patent/CA1025866A/en not_active Expired
- 1972-11-17 JP JP11485972A patent/JPS5523831B2/ja not_active Expired
- 1972-11-17 CH CH74776A patent/CH612430A5/xx not_active IP Right Cessation
- 1972-11-17 CH CH1681572A patent/CH590265A5/xx not_active IP Right Cessation
- 1972-11-17 CH CH74876A patent/CH592080A5/xx not_active IP Right Cessation
- 1972-11-20 GB GB5355072A patent/GB1407854A/en not_active Expired
-
1976
- 1976-01-09 JP JP51002003A patent/JPS5253872A/ja active Granted
- 1976-01-09 JP JP51002004A patent/JPS5253873A/ja active Granted
- 1976-01-09 JP JP51002002A patent/JPS5253871A/ja active Granted
-
1979
- 1979-10-26 US US06/088,338 patent/US4374990A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE2157424C3 (de) | 1980-09-25 |
| CH613202A5 (forum.php) | 1979-09-14 |
| JPS5253871A (en) | 1977-04-30 |
| ATA981272A (de) | 1975-04-15 |
| CH612430A5 (forum.php) | 1979-07-31 |
| CA1025866A (en) | 1978-02-07 |
| DE2240665A1 (de) | 1974-03-07 |
| JPS5523831B2 (forum.php) | 1980-06-25 |
| AT327203B (de) | 1976-01-26 |
| GB1407854A (en) | 1975-09-24 |
| SE408423B (sv) | 1979-06-11 |
| DE2240665C2 (de) | 1982-07-08 |
| JPS5760350B2 (forum.php) | 1982-12-18 |
| NL170147C (nl) | 1982-10-01 |
| JPS5519219B2 (forum.php) | 1980-05-24 |
| JPS5253872A (en) | 1977-04-30 |
| FR2160611A1 (forum.php) | 1973-06-29 |
| US4374990A (en) | 1983-02-22 |
| DE2157424A1 (de) | 1973-05-24 |
| CH592080A5 (forum.php) | 1977-10-14 |
| NL170147B (nl) | 1982-05-03 |
| JPS4861484A (forum.php) | 1973-08-28 |
| CH590265A5 (forum.php) | 1977-07-29 |
| JPS5440555B2 (forum.php) | 1979-12-04 |
| BE791501A (fr) | 1973-05-17 |
| NL7215416A (forum.php) | 1973-05-22 |
| DE2157424B2 (de) | 1980-01-31 |
| JPS5253873A (en) | 1977-04-30 |
| FR2160611B1 (forum.php) | 1975-11-28 |
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