ES398613A1 - Procedure for the preparation of new 1-substituted - 2 -oxi -2,3 - dihydro-5-aril - 1H - 1,4 - benzodiacepinas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new 1-substituted - 2 -oxi -2,3 - dihydro-5-aril - 1H - 1,4 - benzodiacepinas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES398613A1
ES398613A1 ES398613A ES398613A ES398613A1 ES 398613 A1 ES398613 A1 ES 398613A1 ES 398613 A ES398613 A ES 398613A ES 398613 A ES398613 A ES 398613A ES 398613 A1 ES398613 A1 ES 398613A1
Authority
ES
Spain
Prior art keywords
lower alkyl
substituted
hydrogen
dihydro
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES398613A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of ES398613A1 publication Critical patent/ES398613A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B51/00—Devices for, or methods of, sealing or securing package folds or closures; Devices for gathering or twisting wrappers, or necks of bags
    • B65B51/04—Applying separate sealing or securing members, e.g. clips
    • B65B51/06—Applying adhesive tape

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of new 1-substituted-2-oxy-2,3-dihydro-5-aryl-1H-1,4-benz odiazepines of the general formula (I): **(See formula)** and its pharmaceutically acceptable acid addition salts, wherein X is hydrogen, halogen, trifluoromethyl, nitro, lower alkyl, hydroxyl, or lower alkoxy; R1 is lower alkyl, polyfluoro lower alkyl, phenyl lower alkyl, cycloalkyl, lower alkenyl; R2 is hydrogen, lower alkyl, hydroxyl, or lower alkanoyloxy; R3 is phenyl, X-substituted phenyl, naphthyl, thienyl or pyrrile; and R4 is hydrogen, lower alkyl or the group (see formula) in which n is 0 or 1 and R5 and R6 are hydrogen or lower alkyl, characterized by the fact that a compound of the general formula (IV) is reduced: **(See formula)** in the keto group, so that a 2-hydroxy compound of formula I is obtained; and that, if it were convenient, the 2-hydroxy compound is etherified. (Machine-translation by Google Translate, not legally binding)
ES398613A 1968-11-26 1972-01-05 Procedure for the preparation of new 1-substituted - 2 -oxi -2,3 - dihydro-5-aril - 1H - 1,4 - benzodiacepinas. (Machine-translation by Google Translate, not legally binding) Expired ES398613A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77923768A 1968-11-26 1968-11-26
US83664469A 1969-06-25 1969-06-25

Publications (1)

Publication Number Publication Date
ES398613A1 true ES398613A1 (en) 1975-05-16

Family

ID=27119557

Family Applications (1)

Application Number Title Priority Date Filing Date
ES398613A Expired ES398613A1 (en) 1968-11-26 1972-01-05 Procedure for the preparation of new 1-substituted - 2 -oxi -2,3 - dihydro-5-aril - 1H - 1,4 - benzodiacepinas. (Machine-translation by Google Translate, not legally binding)

Country Status (18)

Country Link
JP (1) JPS5116432B1 (en)
AT (1) AT314543B (en)
BE (1) BE742124A (en)
CH (2) CH542859A (en)
CY (1) CY836A (en)
DE (1) DE1958742A1 (en)
DK (1) DK133299C (en)
ES (1) ES398613A1 (en)
FI (1) FI50710C (en)
FR (1) FR2024239B1 (en)
GB (2) GB1297630A (en)
HK (1) HK13676A (en)
IL (1) IL33394A (en)
KE (1) KE2598A (en)
NL (1) NL6917680A (en)
NO (1) NO127302B (en)
PL (1) PL80394B1 (en)
SE (1) SE372767B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3723414A (en) * 1970-02-13 1973-03-27 Schering Corp 1-polyfluoroalkyl benzodiazepines
US4056525A (en) * 1975-06-02 1977-11-01 American Home Products Corporation 2,3-dialkoxy-3h-1,4-benzodiazepines
DE4025395A1 (en) * 1990-08-10 1992-02-13 Miele & Cie Covering end edges of furniture plates - involves adhesive tape guide with contact pressure roller and cutter

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3481921A (en) * 1965-10-22 1969-12-02 Hoffmann La Roche Benzodiazepines

Also Published As

Publication number Publication date
HK13676A (en) 1976-03-19
FR2024239B1 (en) 1973-01-12
CH542859A (en) 1973-10-15
DE1958742A1 (en) 1970-07-09
IL33394A0 (en) 1970-01-29
AT314543B (en) 1974-04-10
NL6917680A (en) 1970-05-28
DK133299B (en) 1976-04-26
PL80394B1 (en) 1975-08-30
FI50710C (en) 1976-06-10
IL33394A (en) 1973-08-29
NO127302B (en) 1973-06-04
FI50710B (en) 1976-03-01
BE742124A (en) 1970-05-25
DK133299C (en) 1976-09-20
GB1297630A (en) 1972-11-29
CH534169A (en) 1973-02-28
KE2598A (en) 1976-02-27
SE372767B (en) 1975-01-13
CY836A (en) 1976-09-10
JPS5116432B1 (en) 1976-05-24
GB1297629A (en) 1972-11-29
FR2024239A1 (en) 1970-08-28

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