ES367957A1 - A procedure for the preparation of benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES367957A1
ES367957A1 ES367957A ES367957A ES367957A1 ES 367957 A1 ES367957 A1 ES 367957A1 ES 367957 A ES367957 A ES 367957A ES 367957 A ES367957 A ES 367957A ES 367957 A1 ES367957 A1 ES 367957A1
Authority
ES
Spain
Prior art keywords
translation
procedure
preparation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES367957A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES367957A1 publication Critical patent/ES367957A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C07D243/32—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings containing a phthalimide or hydrogenated phthalimide ring system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of benzodiazepine derivatives of the general formula **(See formula)** wherein R1 and R2 represent lower alkyl; R3 and R4 represent hydrogen, halogen or trifluoromethyl; and n is an integer valued from 2 to 5, characterized by cyclizing a compound of the general formula **(See formula)** where R1, R2, R3, R4 and n have the same meaning as before. (Machine-translation by Google Translate, not legally binding)
ES367957A 1968-06-03 1969-06-02 A procedure for the preparation of benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES367957A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73381768A 1968-06-03 1968-06-03

Publications (1)

Publication Number Publication Date
ES367957A1 true ES367957A1 (en) 1971-04-16

Family

ID=24949221

Family Applications (1)

Application Number Title Priority Date Filing Date
ES367957A Expired ES367957A1 (en) 1968-06-03 1969-06-02 A procedure for the preparation of benzodiacepine derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
AT (1) AT288406B (en)
CH (1) CH513186A (en)
DK (1) DK138044B (en)
ES (1) ES367957A1 (en)
HU (1) HU164254B (en)
NL (1) NL6908397A (en)
SE (2) SE6907764A0 (en)
YU (1) YU34203B (en)

Also Published As

Publication number Publication date
AT288406B (en) 1971-03-10
SE413242B (en) 1980-05-12
SE6907764A0 (en) 1969-12-04
NL6908397A (en) 1969-12-05
DK138044C (en) 1978-11-20
HU164254B (en) 1974-01-28
YU34203B (en) 1979-02-28
CH513186A (en) 1971-09-30
DK138044B (en) 1978-07-03

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