ES388863A1 - Procedimiento para la obtencion de biguanidas. - Google Patents
Procedimiento para la obtencion de biguanidas.Info
- Publication number
- ES388863A1 ES388863A1 ES388863A ES388863A ES388863A1 ES 388863 A1 ES388863 A1 ES 388863A1 ES 388863 A ES388863 A ES 388863A ES 388863 A ES388863 A ES 388863A ES 388863 A1 ES388863 A1 ES 388863A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- general formula
- meaning
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940123208 Biguanide Drugs 0.000 title abstract 2
- 150000004283 biguanides Chemical class 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702009743 DE2009743A1 (de) | 1970-03-03 | 1970-03-03 | Substituierte Biguanide mit antihyperglykämischer Wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES388863A1 true ES388863A1 (es) | 1973-06-01 |
Family
ID=5763819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES388863A Expired ES388863A1 (es) | 1970-03-03 | 1971-03-03 | Procedimiento para la obtencion de biguanidas. |
| ES391629A Expired ES391629A1 (es) | 1970-03-03 | 1971-05-27 | Procedimiento para la obtencion de biguanidas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391629A Expired ES391629A1 (es) | 1970-03-03 | 1971-05-27 | Procedimiento para la obtencion de biguanidas. |
Country Status (11)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2064664C (en) * | 1991-04-05 | 2000-01-11 | Hiroshi Ishikawa | Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives |
| DE19616486C5 (de) | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Verfahren zur Senkung des Blutglukosespiegels in Säugern |
| DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
| DE19834591A1 (de) | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Verfahren zur Steigerung des Blutglukosespiegels in Säugern |
| DE19926233C1 (de) | 1999-06-10 | 2000-10-19 | Probiodrug Ges Fuer Arzneim | Verfahren zur Herstellung von Thiazolidin |
| US6500804B2 (en) | 2000-03-31 | 2002-12-31 | Probiodrug Ag | Method for the improvement of islet signaling in diabetes mellitus and for its prevention |
| US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
| FR2822464B1 (fr) | 2001-03-21 | 2004-08-06 | Lipha | Derives biguanides et leurs applications en therapeutique |
| US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
| US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
| DE10150203A1 (de) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Peptidylketone als Inhibitoren der DPIV |
| US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
| US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
| CZ2004973A3 (cs) | 2002-02-28 | 2004-12-15 | Prosidion Limited | Inhibitory DPIV na bázi glutaminylu |
| WO2003086563A2 (en) * | 2002-04-11 | 2003-10-23 | Carbomer, Inc. | Diabetes imaging probes |
| NZ568459A (en) | 2003-05-05 | 2009-06-26 | Probiodrug Ag | Use of effectors of glutaminyl and glutamate cyclases |
| ZA200508439B (en) | 2003-05-05 | 2007-03-28 | Probiodrug Ag | Medical use of inhibitors of glutaminyl and glutamate cyclases |
| JP4996926B2 (ja) | 2004-02-05 | 2012-08-08 | プロビオドルグ エージー | グルタミニルシクラーゼの新規の阻害剤 |
| CN110615886A (zh) * | 2019-09-05 | 2019-12-27 | 哈尔滨工程大学 | 一种双胍衍生物抗菌型环氧树脂固化剂及其制备方法 |
| CN115960018B (zh) * | 2022-12-19 | 2024-01-05 | 湖南岳靶生物医药有限公司 | 一种egfr抑制剂、组合物及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR940304A (fr) * | 1946-01-07 | 1948-12-09 | Ici Ltd | Procédé de fabrication de dérivés de biguanides |
| FR1053761A (fr) * | 1949-01-31 | 1954-02-04 | Ici Ltd | Fabrication de dérivés de la biguanide |
| BE612641A (enrdf_load_stackoverflow) * | 1961-01-18 | |||
| FR6786M (enrdf_load_stackoverflow) * | 1967-08-10 | 1969-03-17 |
-
1970
- 1970-03-03 DE DE19702009743 patent/DE2009743A1/de active Pending
-
1971
- 1971-02-10 CH CH197171A patent/CH553756A/xx not_active IP Right Cessation
- 1971-02-10 CH CH1459473A patent/CH564526A5/xx not_active IP Right Cessation
- 1971-02-23 IE IE227/71A patent/IE34966B1/xx unknown
- 1971-02-23 IL IL7136271A patent/IL36271A0/xx unknown
- 1971-02-26 NL NL7102612A patent/NL7102612A/xx unknown
- 1971-02-26 ZA ZA711269A patent/ZA711269B/xx unknown
- 1971-03-02 AT AT176071A patent/AT302350B/de not_active IP Right Cessation
- 1971-03-03 FR FR7107367A patent/FR2085665B1/fr not_active Expired
- 1971-03-03 BE BE763725A patent/BE763725A/xx unknown
- 1971-03-03 ES ES388863A patent/ES388863A1/es not_active Expired
- 1971-04-19 GB GB2281571A patent/GB1343831A/en not_active Expired
- 1971-05-27 ES ES391629A patent/ES391629A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES391629A1 (es) | 1974-09-16 |
| AT302350B (de) | 1972-10-10 |
| IL36271A0 (en) | 1971-04-28 |
| BE763725A (enrdf_load_stackoverflow) | 1971-09-03 |
| IE34966B1 (en) | 1975-10-01 |
| IE34966L (en) | 1971-09-03 |
| NL7102612A (enrdf_load_stackoverflow) | 1971-09-07 |
| DE2009743A1 (de) | 1971-09-16 |
| GB1343831A (en) | 1974-01-16 |
| FR2085665A1 (enrdf_load_stackoverflow) | 1971-12-31 |
| FR2085665B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| ZA711269B (en) | 1971-11-24 |
| CH553756A (de) | 1974-09-13 |
| CH564526A5 (enrdf_load_stackoverflow) | 1975-07-31 |
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