ES388863A1 - Pharmaceutical use of certain substituted biguanides - Google Patents
Pharmaceutical use of certain substituted biguanidesInfo
- Publication number
- ES388863A1 ES388863A1 ES388863A ES388863A ES388863A1 ES 388863 A1 ES388863 A1 ES 388863A1 ES 388863 A ES388863 A ES 388863A ES 388863 A ES388863 A ES 388863A ES 388863 A1 ES388863 A1 ES 388863A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- general formula
- meaning
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
- C07C279/26—X and Y being nitrogen atoms, i.e. biguanides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedure for obtaining biguanides of general formula: **(See formula)** and its salts with non-toxic acids, in which formula R and R1 may be the same or different and represent fluorine, a linear or branched alkyl or alkenyl radical, which contains from 1 to 6 carbon atoms, and which may eventually contain from 1 to 3 fluorine atoms, a cycloalkyl, cycloalkylalkyl or cycloalkenyl radical containing from 5 to 8 carbon atoms, an alkoxy or alkyl mercapto radical containing from 1 to 4 carbon atoms, an alkylsulfonyl group containing from 1 to 4 carbon atoms, or a nitrile group, R1 can also mean hydrogen, chlorine or bromine, R2 represents an alkyl, alkenyl, cycloalkyl or alkoxyalkyl group with 1 to 12, preferably 2 to 8 carbon atoms, which, if it contains more than 3 carbon atoms, can also be branched, and R3 means hydrogen or has the same meaning as R2, where R2 and R3 can be the same or different and contain together no more than 9 carbon atoms, characterized by that aromatic amines attics of the general formula **(See formula)** wherein R2 and R3 have the above meaning are reacted with dicyandiamides of the general formula **(See formula)** where R2 and R3 have the meaning above. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702009743 DE2009743A1 (en) | 1970-03-03 | 1970-03-03 | Substituted biguanides with antihyperglycemic effects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES388863A1 true ES388863A1 (en) | 1973-06-01 |
Family
ID=5763819
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES388863A Expired ES388863A1 (en) | 1970-03-03 | 1971-03-03 | Pharmaceutical use of certain substituted biguanides |
| ES391629A Expired ES391629A1 (en) | 1970-03-03 | 1971-05-27 | Pharmaceutical use of certain substituted biguanides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES391629A Expired ES391629A1 (en) | 1970-03-03 | 1971-05-27 | Pharmaceutical use of certain substituted biguanides |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT302350B (en) |
| BE (1) | BE763725A (en) |
| CH (2) | CH553756A (en) |
| DE (1) | DE2009743A1 (en) |
| ES (2) | ES388863A1 (en) |
| FR (1) | FR2085665B1 (en) |
| GB (1) | GB1343831A (en) |
| IE (1) | IE34966B1 (en) |
| IL (1) | IL36271A0 (en) |
| NL (1) | NL7102612A (en) |
| ZA (1) | ZA711269B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2064664C (en) * | 1991-04-05 | 2000-01-11 | Hiroshi Ishikawa | Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives |
| DE19616486C5 (en) | 1996-04-25 | 2016-06-30 | Royalty Pharma Collection Trust | Method for lowering the blood glucose level in mammals |
| DE19828113A1 (en) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs of Dipeptidyl Peptidase IV Inhibitors |
| DE19828114A1 (en) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs of unstable inhibitors of dipeptidyl peptidase IV |
| DE19834591A1 (en) | 1998-07-31 | 2000-02-03 | Probiodrug Ges Fuer Arzneim | Use of substances that decrease the activity of dipeptidyl peptidase IV to increase blood sugar levels, e.g. for treating hypoglycemia |
| DE19926233C1 (en) | 1999-06-10 | 2000-10-19 | Probiodrug Ges Fuer Arzneim | Production of thiazolidine, useful as pharmaceutical intermediate, comprises reacting hexamethylenetetramine with cysteamine |
| DK1283735T4 (en) | 2000-03-31 | 2013-02-04 | Royalty Pharma Collection Trust | Method for improving islet cell signaling in diabetes mellitus and for its prevention |
| US7132104B1 (en) | 2000-10-27 | 2006-11-07 | Probiodrug Ag | Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders |
| FR2822464B1 (en) * | 2001-03-21 | 2004-08-06 | Lipha | BIGUANIDE DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS |
| US6890905B2 (en) | 2001-04-02 | 2005-05-10 | Prosidion Limited | Methods for improving islet signaling in diabetes mellitus and for its prevention |
| DE10150203A1 (en) | 2001-10-12 | 2003-04-17 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitor in treatment of cancer |
| US20030130199A1 (en) | 2001-06-27 | 2003-07-10 | Von Hoersten Stephan | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents |
| US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
| US6844316B2 (en) | 2001-09-06 | 2005-01-18 | Probiodrug Ag | Inhibitors of dipeptidyl peptidase I |
| SI1480961T1 (en) | 2002-02-28 | 2007-06-30 | Prosidion Ltd | Glutaminyl based dpiv inhibitors |
| WO2003086563A2 (en) * | 2002-04-11 | 2003-10-23 | Carbomer, Inc. | Diabetes imaging probes |
| US7371871B2 (en) | 2003-05-05 | 2008-05-13 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| CN101837127A (en) | 2003-05-05 | 2010-09-22 | 前体生物药物股份公司 | The application of glutaminyl and glutamate cyclase effector |
| CA2554809C (en) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
| CN110615886A (en) * | 2019-09-05 | 2019-12-27 | 哈尔滨工程大学 | Biguanide derivative antibacterial epoxy resin curing agent and preparation method thereof |
| CN115960018B (en) * | 2022-12-19 | 2024-01-05 | 湖南岳靶生物医药有限公司 | EGFR inhibitor, composition and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR940304A (en) * | 1946-01-07 | 1948-12-09 | Ici Ltd | Manufacturing process for biguanide derivatives |
| FR1053761A (en) * | 1949-01-31 | 1954-02-04 | Ici Ltd | Manufacture of biguanide derivatives |
| BE612641A (en) * | 1961-01-18 | |||
| FR6786M (en) * | 1967-08-10 | 1969-03-17 |
-
1970
- 1970-03-03 DE DE19702009743 patent/DE2009743A1/en active Pending
-
1971
- 1971-02-10 CH CH197171A patent/CH553756A/en not_active IP Right Cessation
- 1971-02-10 CH CH1459473A patent/CH564526A5/xx not_active IP Right Cessation
- 1971-02-23 IE IE227/71A patent/IE34966B1/en unknown
- 1971-02-23 IL IL7136271A patent/IL36271A0/en unknown
- 1971-02-26 ZA ZA711269A patent/ZA711269B/en unknown
- 1971-02-26 NL NL7102612A patent/NL7102612A/xx unknown
- 1971-03-02 AT AT176071A patent/AT302350B/en not_active IP Right Cessation
- 1971-03-03 FR FR7107367A patent/FR2085665B1/fr not_active Expired
- 1971-03-03 BE BE763725A patent/BE763725A/xx unknown
- 1971-03-03 ES ES388863A patent/ES388863A1/en not_active Expired
- 1971-04-19 GB GB2281571A patent/GB1343831A/en not_active Expired
- 1971-05-27 ES ES391629A patent/ES391629A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH553756A (en) | 1974-09-13 |
| GB1343831A (en) | 1974-01-16 |
| IE34966L (en) | 1971-09-03 |
| DE2009743A1 (en) | 1971-09-16 |
| BE763725A (en) | 1971-09-03 |
| ES391629A1 (en) | 1974-09-16 |
| NL7102612A (en) | 1971-09-07 |
| CH564526A5 (en) | 1975-07-31 |
| IL36271A0 (en) | 1971-04-28 |
| IE34966B1 (en) | 1975-10-01 |
| AT302350B (en) | 1972-10-10 |
| ZA711269B (en) | 1971-11-24 |
| FR2085665B1 (en) | 1974-08-30 |
| FR2085665A1 (en) | 1971-12-31 |
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