ES387553A1 - Procedimiento para la preparacion de 4-morfolino-tieno (3,-2-d)-pirimidinas. - Google Patents
Procedimiento para la preparacion de 4-morfolino-tieno (3,-2-d)-pirimidinas.Info
- Publication number
- ES387553A1 ES387553A1 ES387553A ES387553A ES387553A1 ES 387553 A1 ES387553 A1 ES 387553A1 ES 387553 A ES387553 A ES 387553A ES 387553 A ES387553 A ES 387553A ES 387553 A1 ES387553 A1 ES 387553A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- radical
- compound
- signify
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 150000007522 mineralic acids Chemical class 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 2
- ZEWWLZDNTOZATC-UHFFFAOYSA-N 4-thieno[3,2-d]pyrimidin-4-ylmorpholine Chemical class C1COCCN1C1=NC=NC2=C1SC=C2 ZEWWLZDNTOZATC-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19702003714 DE2003714C (de) | 1970-01-28 | 2 Piperazino 4 morpholino thieno eckige Klammer auf 3,2 d eckige Klammer zu pyrimidin und dessen Saureadditions salze | |
| DE19702058085 DE2058085A1 (de) | 1970-11-26 | 1970-11-26 | Neues Verfahren zur Herstellung von 4-Morpholino-thieno[3,2-d]pyrimidinen |
| DE19702058086 DE2058086A1 (de) | 1970-11-26 | 1970-11-26 | Neue 4-Morpholino-thieno[3,2-d]pyrimidine,deren Salze und Verfahren zur Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES387553A1 true ES387553A1 (es) | 1974-01-16 |
Family
ID=27182372
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES387553A Expired ES387553A1 (es) | 1970-01-28 | 1971-01-23 | Procedimiento para la preparacion de 4-morfolino-tieno (3,-2-d)-pirimidinas. |
| ES387554A Expired ES387554A1 (es) | 1970-01-28 | 1971-01-23 | Procedimiento para la preparacion de 4-morfolino - tieno (3,2) pirimidinas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES387554A Expired ES387554A1 (es) | 1970-01-28 | 1971-01-23 | Procedimiento para la preparacion de 4-morfolino - tieno (3,2) pirimidinas. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3763156A (forum.php) |
| AU (1) | AU2468871A (forum.php) |
| BE (1) | BE762135A (forum.php) |
| ES (2) | ES387553A1 (forum.php) |
| FR (1) | FR2081464B1 (forum.php) |
| GB (1) | GB1309182A (forum.php) |
| IL (1) | IL36079A0 (forum.php) |
| NL (1) | NL7101043A (forum.php) |
| NO (1) | NO129205B (forum.php) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| GB8912335D0 (en) * | 1989-05-30 | 1989-07-12 | Smithkline Beckman Intercredit | Compounds |
| US5280026A (en) * | 1989-05-30 | 1994-01-18 | Smithkline Beecham Intercredit B.V. | Thienopyrimidines |
| US5098902A (en) * | 1991-03-18 | 1992-03-24 | Warner-Lambert Company | Method of treating neurodegenerative diseases |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| US6608053B2 (en) * | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| GB0423653D0 (en) * | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| BRPI0608387A2 (pt) * | 2006-04-19 | 2009-12-29 | Boehringer Ingelheim Int | compostos para o tratamento de doenças inflamatórias |
| CL2007001166A1 (es) | 2006-04-26 | 2008-01-25 | Piramed Ltd | Compuestos derivados de pirimidina condensada, inhibidores de pi3-quinasa; procesos para preparar los compuestos; composicion farmaceutica que los comprende; uso de los compuestos en la preparacion de medicamentos; proceso para preparar la composicion farmaceutica; y kit que incluye a la composicion farmaceutica |
| CN101472930B (zh) | 2006-04-26 | 2011-12-14 | 霍夫曼-拉罗奇有限公司 | 用作PI3K抑制剂的噻吩并[3,2-d]嘧啶的衍生物 |
| PT2041139E (pt) | 2006-04-26 | 2012-01-13 | Hoffmann La Roche | Compostos farmacêuticos |
| BRPI0717923A2 (pt) * | 2006-12-07 | 2013-10-22 | Genentech In | '' composto, composição farmacêutica, método para tratar um câncer, processo para a produção de uma composição farmacêutica, usos, métodos para inibir ou modular a atividade da lipídeo quinase e kit ' ' |
| ZA200904531B (en) * | 2006-12-07 | 2010-09-29 | Hoffmann La Roche | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| EP2207781B1 (en) | 2007-09-24 | 2012-11-28 | Genentech, Inc. | Thiazolopyrimidine p13k inhibitor compounds and methods of use |
| CA2702518A1 (en) | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | New piperazino-dihydrothienopyrimidine derivatives |
| NZ585346A (en) * | 2007-10-19 | 2011-09-30 | Boehringer Ingelheim Int | Substituted piperidino-dihydrothienopyrimidines |
| NZ585348A (en) | 2007-10-19 | 2012-02-24 | Boehringer Ingelheim Int | Heterocycle-substituted piperazino-dihydrothienopyrimidines |
| EP2214675B1 (en) | 2007-10-25 | 2013-11-20 | Genentech, Inc. | Process for making thienopyrimidine compounds |
| GB0721095D0 (en) * | 2007-10-26 | 2007-12-05 | Piramed Ltd | Pharmaceutical compounds |
| AU2010224125B2 (en) | 2009-03-12 | 2015-05-14 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of hematopoietic malignancies |
| EP2435438A1 (en) | 2009-05-27 | 2012-04-04 | Genentech, Inc. | Bicyclic pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| WO2010136491A1 (en) * | 2009-05-27 | 2010-12-02 | F. Hoffmann-La Roche Ag | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| AU2010314287A1 (en) * | 2009-10-12 | 2012-05-03 | F. Hoffmann-La Roche Ag | Combinations of a PI3K inhibitor and a MEK inhibitor |
| WO2011130654A1 (en) | 2010-04-16 | 2011-10-20 | Genentech, Inc. | Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy |
| US20140004209A1 (en) | 2010-12-22 | 2014-01-02 | Genentech, Inc. | Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9802954B2 (en) | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| MX369175B (es) | 2013-02-25 | 2019-10-30 | Genentech Inc | Métodos para detectar mutantes de akt resistentes a fármacos. |
| CN113423711B (zh) * | 2018-10-01 | 2024-03-15 | 建新公司 | 作为udp糖基转移酶抑制剂的噻吩并[3,2-b]吡啶衍生物及其使用方法 |
| GB202014736D0 (en) * | 2020-09-18 | 2020-11-04 | Imperial College Innovations Ltd | Novel compounds and their use in therapy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1470356A1 (de) * | 1964-01-15 | 1970-04-30 | Thomae Gmbh Dr K | Neue Thieno[3,2-d]pyrimidine und Verfahren zu ihrer Herstellung |
-
1971
- 1971-01-22 US US00108988A patent/US3763156A/en not_active Expired - Lifetime
- 1971-01-23 ES ES387553A patent/ES387553A1/es not_active Expired
- 1971-01-23 ES ES387554A patent/ES387554A1/es not_active Expired
- 1971-01-26 AU AU24688/71A patent/AU2468871A/en not_active Expired
- 1971-01-27 IL IL36079A patent/IL36079A0/xx unknown
- 1971-01-27 NL NL7101043A patent/NL7101043A/xx unknown
- 1971-01-27 BE BE762135A patent/BE762135A/xx unknown
- 1971-01-27 NO NO00283/71A patent/NO129205B/no unknown
- 1971-01-28 FR FR7102796A patent/FR2081464B1/fr not_active Expired
- 1971-04-19 GB GB2046471A patent/GB1309182A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES387554A1 (es) | 1974-01-16 |
| FR2081464A1 (forum.php) | 1971-12-03 |
| NL7101043A (forum.php) | 1971-07-30 |
| AU2468871A (en) | 1972-07-27 |
| BE762135A (fr) | 1971-07-27 |
| US3763156A (en) | 1973-10-02 |
| IL36079A0 (en) | 1971-03-24 |
| FR2081464B1 (forum.php) | 1975-04-18 |
| NO129205B (forum.php) | 1974-03-11 |
| GB1309182A (en) | 1973-03-07 |
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