ES355674A1 - Metodo de producir amidas basicamente sustituidas de acidosantranilicos n-sustituidos y sales de las mismas. - Google Patents
Metodo de producir amidas basicamente sustituidas de acidosantranilicos n-sustituidos y sales de las mismas.Info
- Publication number
- ES355674A1 ES355674A1 ES355674A ES355674A ES355674A1 ES 355674 A1 ES355674 A1 ES 355674A1 ES 355674 A ES355674 A ES 355674A ES 355674 A ES355674 A ES 355674A ES 355674 A1 ES355674 A1 ES 355674A1
- Authority
- ES
- Spain
- Prior art keywords
- acid
- substituted
- reacting
- anthronilic
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- -1 N-substituted anthranilic acid amides Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 abstract 2
- OPDUMRSBESYOCQ-UHFFFAOYSA-N 1-(2,3-dimethylphenyl)-3,1-benzoxazine-2,4-dione Chemical compound CC1=CC=CC(N2C(OC(=O)C3=CC=CC=C32)=O)=C1C OPDUMRSBESYOCQ-UHFFFAOYSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N N-phenyl amine Natural products NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 150000001448 anilines Chemical class 0.000 abstract 1
- 150000001555 benzenes Chemical class 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- VYFOAVADNIHPTR-UHFFFAOYSA-N isatoic anhydride Chemical class NC1=CC=CC=C1CO VYFOAVADNIHPTR-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N o-aminobenzenecarboxylic acid Natural products NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK342267A DK121236B (da) | 1967-07-03 | 1967-07-03 | Analogifremgangsmåde til fremstilling af terapeutisk aktive, basisk substituerede amider af N-substituerede antranilsyrer, eller syreadditionssalte deraf. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES355674A1 true ES355674A1 (es) | 1970-01-01 |
Family
ID=8122684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES355674A Expired ES355674A1 (es) | 1967-07-03 | 1968-07-02 | Metodo de producir amidas basicamente sustituidas de acidosantranilicos n-sustituidos y sales de las mismas. |
Country Status (13)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| PL2623495T3 (pl) * | 2006-09-03 | 2019-11-29 | Techfields Biochem Co Ltd | Dodatnio naładowane rozpuszczalne w wodzie proleki kwasów n-aryloantranilowych o bardzo dużej szybkości przenikania przez skórę |
| CN101687792B (zh) | 2007-06-04 | 2016-03-02 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其医药用途 |
| KR20210123406A (ko) | 2008-12-04 | 2021-10-13 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
| HK1207562A1 (en) | 2012-01-18 | 2016-02-05 | 苏州泰飞尔医药有限公司 | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
| JP6153264B2 (ja) * | 2015-01-05 | 2017-06-28 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用 |
-
1967
- 1967-07-03 DK DK342267A patent/DK121236B/da not_active IP Right Cessation
-
1968
- 1968-06-24 IE IE74768A patent/IE32158B1/xx unknown
- 1968-06-25 GB GB3033568A patent/GB1165300A/en not_active Expired
- 1968-07-02 ES ES355674A patent/ES355674A1/es not_active Expired
- 1968-07-02 NO NO265268A patent/NO121213B/no unknown
- 1968-07-02 BR BR20033268A patent/BR6800332D0/pt unknown
- 1968-07-02 CH CH989768A patent/CH512436A/de not_active IP Right Cessation
- 1968-07-02 FR FR1584334D patent/FR1584334A/fr not_active Expired
- 1968-07-02 NL NL6809321A patent/NL163503C/xx active
- 1968-07-03 BE BE717543D patent/BE717543A/xx unknown
- 1968-07-03 CA CA024135A patent/CA921051A/en not_active Expired
- 1968-07-03 SE SE918268A patent/SE363504B/xx unknown
- 1968-07-03 FI FI191768A patent/FI49024C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| BE717543A (enrdf_load_stackoverflow) | 1968-12-16 |
| GB1165300A (en) | 1969-09-24 |
| NL163503B (nl) | 1980-04-15 |
| NL163503C (nl) | 1980-09-15 |
| NL6809321A (enrdf_load_stackoverflow) | 1969-01-07 |
| IE32158B1 (en) | 1973-05-02 |
| DE1768818B2 (de) | 1977-05-05 |
| FR1584334A (enrdf_load_stackoverflow) | 1969-12-19 |
| SE363504B (enrdf_load_stackoverflow) | 1974-01-21 |
| DK121236B (da) | 1971-09-27 |
| BR6800332D0 (pt) | 1973-02-13 |
| DE1768818A1 (de) | 1971-12-30 |
| NO121213B (enrdf_load_stackoverflow) | 1971-02-01 |
| FI49024C (fi) | 1975-03-10 |
| CA921051A (en) | 1973-02-13 |
| FI49024B (enrdf_load_stackoverflow) | 1974-12-02 |
| CH512436A (de) | 1971-09-15 |
| IE32158L (en) | 1969-01-03 |
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