ES315990A1 - Procedimiento para la preparaciën de nuevos derivados de guanidina - Google Patents
Procedimiento para la preparaciën de nuevos derivados de guanidinaInfo
- Publication number
- ES315990A1 ES315990A1 ES0315990A ES315990A ES315990A1 ES 315990 A1 ES315990 A1 ES 315990A1 ES 0315990 A ES0315990 A ES 0315990A ES 315990 A ES315990 A ES 315990A ES 315990 A1 ES315990 A1 ES 315990A1
- Authority
- ES
- Spain
- Prior art keywords
- adamant
- general formula
- addition salt
- acid addition
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1007264A CH448068A (de) | 1964-07-31 | 1964-07-31 | Verfahren zur Herstellung von neuen Guanidinderivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES315990A1 true ES315990A1 (es) | 1966-04-01 |
Family
ID=4359025
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0315990A Expired ES315990A1 (es) | 1964-07-31 | 1965-07-30 | Procedimiento para la preparaciën de nuevos derivados de guanidina |
| ES0315989A Expired ES315989A1 (es) | 1964-07-31 | 1965-07-30 | Procedimiento para la preparaciën de nuevos derivados de guanidina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0315989A Expired ES315989A1 (es) | 1964-07-31 | 1965-07-30 | Procedimiento para la preparaciën de nuevos derivados de guanidina |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3270054A (es) |
| AT (3) | AT257632B (es) |
| BE (1) | BE667692A (es) |
| DE (1) | DE1235904B (es) |
| ES (2) | ES315990A1 (es) |
| FR (1) | FR4976M (es) |
| GB (1) | GB1063749A (es) |
| NL (2) | NL6509927A (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH435243A (de) * | 1964-03-26 | 1967-05-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen N'-substituierten N-Arylsulfonyl-harnstoffen |
| NL6503019A (es) * | 1965-03-10 | 1966-09-12 | ||
| US3873717A (en) * | 1970-11-20 | 1975-03-25 | Ciba Geigy Corp | Certain 2,2-dimethyl-propanal-carbamoyloximes fungicides |
| DD104782A1 (es) * | 1972-05-29 | 1974-03-20 | ||
| NL7307651A (es) * | 1972-06-07 | 1973-12-11 | ||
| US4007181A (en) * | 1974-02-11 | 1977-02-08 | The Upjohn Company | Adamantyl containing guanidines |
| US5312840A (en) * | 1986-07-10 | 1994-05-17 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| US5385946A (en) * | 1986-07-10 | 1995-01-31 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Method for treating hypertension with disubstituted granidine compounds |
| US5336689A (en) * | 1990-03-02 | 1994-08-09 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
| DE69133065T2 (de) | 1990-03-02 | 2003-02-27 | Oregon State | Tri- und tetra-substituierte guanidine und deren verwendung als antagonisten von exzitatorischen aminosäuren |
| US5262568A (en) * | 1990-03-02 | 1993-11-16 | State Of Oregon | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists |
| WO1991018868A1 (en) * | 1990-05-25 | 1991-12-12 | STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY | Substituted guanidines having high binding to the sigma receptor and the use thereof |
| US5741661A (en) * | 1991-02-08 | 1998-04-21 | Cambridge Neuroscience, Inc. | Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers |
| ATE288262T1 (de) * | 1991-02-08 | 2005-02-15 | Scion Pharmaceuticals Inc | Substituierte guanidine und derivate hiervon als modulatoren der freisetzung von neurotransmittern und neue methode zur identifizierung von inhibitoren der neurotransmitter-freisetzung |
| US5847006A (en) * | 1991-02-08 | 1998-12-08 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
| WO1994027591A1 (en) * | 1993-05-27 | 1994-12-08 | Cambridge Neuroscience, Inc. | Therapeutic substituted guanidines |
| CA2177081A1 (en) * | 1993-11-23 | 1995-06-01 | Graham J. Durant | Therapeutic substituted guanidines |
| US7351743B1 (en) | 1994-02-03 | 2008-04-01 | Wyeth | Therapeutic guanidines |
| EP0751767A4 (en) | 1994-02-03 | 1997-12-10 | Cambridge Neuroscience Inc | GUANIDINE FOR THERAPEUTIC USE |
| US6787569B1 (en) | 1994-02-03 | 2004-09-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
| US6143791A (en) * | 1994-02-03 | 2000-11-07 | Cambridge Neuroscience, Inc. | Therapeutic guanidines |
| US6025355A (en) | 1997-05-19 | 2000-02-15 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| US6242198B1 (en) | 1996-07-25 | 2001-06-05 | Cambridge Neuroscience, Inc. | Methods of treatment of eye trauma and disorders |
| US6756389B2 (en) | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| CN104628615B (zh) * | 2015-02-12 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | 含卤代苯的n-金刚烷酰胺类化合物、其制备方法及其用途 |
| CN104693084B (zh) * | 2015-02-12 | 2016-03-16 | 佛山市赛维斯医药科技有限公司 | 含腈基苯基的n-金刚烷酰胺类化合物、其制备方法及用途 |
| CN104628617B (zh) * | 2015-02-12 | 2016-04-06 | 佛山市赛维斯医药科技有限公司 | N-金刚烷酰胺类葡萄糖激酶活化剂、制备方法及其用途 |
| CN104628616B (zh) * | 2015-02-12 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 含对硝基苯基的n-金刚烷酰胺类化合物、其制备方法及用途 |
-
0
- NL NL125066D patent/NL125066C/xx active
-
1965
- 1965-07-22 US US474177A patent/US3270054A/en not_active Expired - Lifetime
- 1965-07-30 ES ES0315990A patent/ES315990A1/es not_active Expired
- 1965-07-30 AT AT707765A patent/AT257632B/de active
- 1965-07-30 ES ES0315989A patent/ES315989A1/es not_active Expired
- 1965-07-30 AT AT1051066A patent/AT257634B/de active
- 1965-07-30 DE DEG44313A patent/DE1235904B/de active Pending
- 1965-07-30 BE BE667692D patent/BE667692A/xx unknown
- 1965-07-30 AT AT1050966A patent/AT257633B/de active
- 1965-07-30 GB GB32614/65A patent/GB1063749A/en not_active Expired
- 1965-07-30 NL NL6509927A patent/NL6509927A/xx unknown
- 1965-10-30 FR FR36841A patent/FR4976M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AT257632B (de) | 1967-10-10 |
| NL125066C (es) | |
| AT257633B (de) | 1967-10-10 |
| US3270054A (en) | 1966-08-30 |
| ES315989A1 (es) | 1966-04-01 |
| BE667692A (es) | 1966-01-31 |
| AT257634B (de) | 1967-10-10 |
| FR4976M (es) | 1967-04-10 |
| GB1063749A (en) | 1967-03-30 |
| NL6509927A (es) | 1966-02-01 |
| DE1235904B (de) | 1967-03-09 |
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