ES347613A1 - Benzenesulphonyl ureas and process for their manufacture - Google Patents
Benzenesulphonyl ureas and process for their manufactureInfo
- Publication number
- ES347613A1 ES347613A1 ES347613A ES347613A ES347613A1 ES 347613 A1 ES347613 A1 ES 347613A1 ES 347613 A ES347613 A ES 347613A ES 347613 A ES347613 A ES 347613A ES 347613 A1 ES347613 A1 ES 347613A1
- Authority
- ES
- Spain
- Prior art keywords
- endomethylene
- cyclohexyl
- methoxy
- ethyl
- benzenesulphonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Abstract
Novel compounds I (including salts thereof) in which R represents a G 1-4 alkyl or C 1-4 alkenyl radical, X represents a hydrogen, fluorine, chlorine or bromine atom, or a C 1-4 alkyl or C 1-4 alkoxy radical in the 4- or 5-position relative to the carbamoyl group, and R1 represents an endomethylene-cyclohexyl, endomethylene - cyclohexenyl, endoethylene - cyclohexyl or endoethylene-cyclohexenyl radical, are prepared utilizing standard methods. 1 -[4- (# - <2 -Methoxy-5 -chlorobenzamido> ethyl) - benzenesulphonyl} - 3 - (2,5 - endomethylene-cyclohexyl)-parabanic acid is obtained by the interaction of endomethylenecyclohexylparabanic acid and the appropriate benzenesulphonic acid chloride. N-[4-(#-<2-Methoxy-5-ahlorobenzamido>- ethyl) - benzenesulphinyl] - N1 - (2,5 - endomethylene-cyclohexyl)-urea is prepared by reacting N - 2,5 - endomethylenecyclohexyl - urea with the appropriate benzenesulphinyl chloride. N - [4 - #-<2-Methoxy-5-chlorobenramido> - ethyl) - benzenesulphonyl] - N1 - (2,5 - endomethylene-cyclohexyl)-thiourea, obtained by reacting the corresponding benzene sulphonamide with 2,5-endomethylenecyclohexyl isocyanate, is converted to N - [4 - # - < 2 - methoxy - 5 - chlorobenzamido> - ethyl) - benzenesulphonyl] - N1- (2,5 - endomethylenecyclohexyl) - isourea methyl ether by treatment with mercury oxide and ethanol in the presence of potassium carbonate followed by crystallization of the product from methanol. Pharmaceutical preparations having hypoglycemic activity contain as active ingredient compounds I administration may be orally, e.g. in the form of a tablet. Reference has been directed by the Comptroller to Specification 1,080,705.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF0050793 | 1966-11-29 | ||
DEF52939A DE1291742B (en) | 1966-11-29 | 1967-07-13 | Process for the preparation of benzenesulfonylureas |
Publications (1)
Publication Number | Publication Date |
---|---|
ES347613A1 true ES347613A1 (en) | 1969-06-01 |
Family
ID=25977518
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES347613A Expired ES347613A1 (en) | 1966-11-29 | 1967-11-25 | Benzenesulphonyl ureas and process for their manufacture |
Country Status (23)
Country | Link |
---|---|
JP (1) | JPS5015790B1 (en) |
AT (5) | AT289822B (en) |
BE (1) | BE707241A (en) |
CH (9) | CH519482A (en) |
CS (7) | CS159738B2 (en) |
CY (1) | CY617A (en) |
DE (2) | DE1568626C3 (en) |
DK (1) | DK120539B (en) |
ES (1) | ES347613A1 (en) |
FI (1) | FI45963C (en) |
FR (2) | FR1571292A (en) |
GB (1) | GB1203425A (en) |
GR (1) | GR37776B (en) |
IL (1) | IL28873A (en) |
IT (1) | IT1056720B (en) |
LU (1) | LU54967A1 (en) |
MC (1) | MC696A1 (en) |
MY (1) | MY7200011A (en) |
NL (1) | NL6716016A (en) |
NO (1) | NO122922B (en) |
OA (1) | OA03381A (en) |
SE (1) | SE339221B (en) |
SU (2) | SU473359A3 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3957866A (en) * | 1970-09-23 | 1976-05-18 | J. Uriach & Cia S.A. | Cyclopentyl carbamide derivative and process for its production |
US4072758A (en) * | 1970-09-23 | 1978-02-07 | J. Uriach Y Cia, S.A. | Compositions and methods for effecting glucoreduction |
JPS54175898U (en) * | 1978-05-31 | 1979-12-12 | ||
JPS5559632U (en) * | 1978-10-20 | 1980-04-23 | ||
JP7072586B2 (en) * | 2017-05-24 | 2022-05-20 | ザ ユニバーシティ オブ クィーンズランド | New compounds and uses |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1192192B (en) * |
-
1966
- 1966-11-29 DE DE1568626A patent/DE1568626C3/en not_active Expired
-
1967
- 1967-07-13 DE DEF52939A patent/DE1291742B/en active Pending
- 1967-11-01 IL IL28873A patent/IL28873A/en unknown
- 1967-11-17 GR GR670137776A patent/GR37776B/en unknown
- 1967-11-23 DK DK587667AA patent/DK120539B/en unknown
- 1967-11-24 FI FI673171A patent/FI45963C/en active
- 1967-11-24 NL NL6716016A patent/NL6716016A/xx unknown
- 1967-11-25 ES ES347613A patent/ES347613A1/en not_active Expired
- 1967-11-27 AT AT127069A patent/AT289822B/en not_active IP Right Cessation
- 1967-11-27 AT AT1069367A patent/AT278845B/en not_active IP Right Cessation
- 1967-11-27 CH CH1068870A patent/CH519482A/en not_active IP Right Cessation
- 1967-11-27 AT AT01272/69A patent/AT278850B/en not_active IP Right Cessation
- 1967-11-27 CH CH1069170A patent/CH518915A/en not_active IP Right Cessation
- 1967-11-27 CH CH1069070A patent/CH519483A/en not_active IP Right Cessation
- 1967-11-27 AT AT127169A patent/AT278849B/en not_active IP Right Cessation
- 1967-11-27 AT AT126869A patent/AT299971B/en not_active IP Right Cessation
- 1967-11-27 CH CH1661567A patent/CH495339A/en not_active IP Right Cessation
- 1967-11-27 CH CH84272A patent/CH519484A/en not_active IP Right Cessation
- 1967-11-27 LU LU54967D patent/LU54967A1/xx unknown
- 1967-11-27 CH CH1068770A patent/CH519481A/en not_active IP Right Cessation
- 1967-11-27 CH CH1068670A patent/CH518913A/en not_active IP Right Cessation
- 1967-11-27 CH CH1069270A patent/CH522608A/en not_active IP Right Cessation
- 1967-11-27 CH CH1068970A patent/CH518914A/en not_active IP Right Cessation
- 1967-11-28 NO NO170728A patent/NO122922B/no unknown
- 1967-11-28 IT IT23246/67A patent/IT1056720B/en active
- 1967-11-28 FR FR1571292D patent/FR1571292A/fr not_active Expired
- 1967-11-28 MC MC733A patent/MC696A1/en unknown
- 1967-11-28 OA OA53110A patent/OA03381A/en unknown
- 1967-11-29 CS CS6600A patent/CS159738B2/cs unknown
- 1967-11-29 SU SU1631861A patent/SU473359A3/en active
- 1967-11-29 CS CS2568*[A patent/CS159741B2/cs unknown
- 1967-11-29 CS CS8447A patent/CS159734B2/cs unknown
- 1967-11-29 CS CS6599A patent/CS159737B2/cs unknown
- 1967-11-29 CS CS6597A patent/CS159735B2/cs unknown
- 1967-11-29 GB GB54301/67A patent/GB1203425A/en not_active Expired
- 1967-11-29 SU SU1418959A patent/SU460621A3/en active
- 1967-11-29 BE BE707241D patent/BE707241A/xx unknown
- 1967-11-29 CS CS6601A patent/CS159739B2/cs unknown
- 1967-11-29 JP JP42076359A patent/JPS5015790B1/ja active Pending
- 1967-11-29 SE SE16358/67A patent/SE339221B/xx unknown
- 1967-11-29 CS CS1541*[A patent/CS159740B2/cs unknown
-
1968
- 1968-02-26 FR FR141253A patent/FR8367M/fr not_active Expired
-
1971
- 1971-10-25 CY CY61771A patent/CY617A/en unknown
-
1972
- 1972-12-30 MY MY11/72A patent/MY7200011A/en unknown
Also Published As
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