ES347576A1 - The manufacture of phenazine derivatives - Google Patents
The manufacture of phenazine derivativesInfo
- Publication number
- ES347576A1 ES347576A1 ES347576A ES347576A ES347576A1 ES 347576 A1 ES347576 A1 ES 347576A1 ES 347576 A ES347576 A ES 347576A ES 347576 A ES347576 A ES 347576A ES 347576 A1 ES347576 A1 ES 347576A1
- Authority
- ES
- Spain
- Prior art keywords
- treating
- phenazine
- monoxide
- dioxide
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
Abstract
Novel phenazine derivatives of the general formula where R1 represents lower alkyl or benzyl are prepared by (a) treating a phenazine N- monoxide of the formula where R1 is as defined above and R2 represents a lower alkyl or benzyl group with a halide of a Group III element and treating the resulting N-monoxide of the general formula with a hydroperoxide or (b) treating a 1,6- dialkoxy (or dibenzyloxy) phenazine N,N-dioxide with a halide of a Group III element and separating the product from the mixture obtained or (c) treating 1,6-phenazene diol-5,10- dioxide with an alkylating agent or a benzylating agent and separating the product from the mixture obtained. The N-monoxide and N,N-dwxide starting materials are obtained by treating the corresponding 1,6-dialkoxy (or dibenzyloxy) phenazine with a hydroperoxide and isolating the product from the mixture obtained. Pharmaceutical compositions comprising compounds of Formula I or an N,N-dioxide in which neither R1 nor R2 is hydrogen, together with a pharmaceutically acceptable carrier, are administered orally or parenterally or have germicidal and broad-spectrum anti-biotic activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59679466A | 1966-11-25 | 1966-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES347576A1 true ES347576A1 (en) | 1969-02-01 |
Family
ID=24388733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES347576A Expired ES347576A1 (en) | 1966-11-25 | 1967-11-24 | The manufacture of phenazine derivatives |
Country Status (14)
| Country | Link |
|---|---|
| AT (2) | AT281851B (en) |
| BE (1) | BE706861A (en) |
| CA (1) | CA946397A (en) |
| CH (3) | CH521358A (en) |
| DE (2) | DE1795724C3 (en) |
| ES (1) | ES347576A1 (en) |
| FR (1) | FR1545331A (en) |
| GB (1) | GB1142448A (en) |
| GR (1) | GR38359B (en) |
| IL (1) | IL28972A (en) |
| NL (2) | NL6715787A (en) |
| NO (1) | NO123528B (en) |
| PH (2) | PH11778A (en) |
| SE (3) | SE366988B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH532589A (en) * | 1969-05-14 | 1973-01-15 | Hoffmann La Roche | Process for the preparation of phenazine derivatives |
| US3681331A (en) * | 1970-04-02 | 1972-08-01 | Hoffmann La Roche | 1-hydroxy-6-amino alkoxy-phenazine 5,10-dioxides |
| CH575213A5 (en) * | 1972-09-05 | 1976-05-14 | Ciba Geigy Ag | |
| CN104974100A (en) * | 2015-07-07 | 2015-10-14 | 江苏省农业科学院 | Phenazine compounds originated from lysobacter antibioticus OH13 and preparation method and application thereof |
-
1967
- 1967-11-08 CH CH503670A patent/CH521358A/en not_active IP Right Cessation
- 1967-11-08 CH CH1048171A patent/CH520694A/en not_active IP Right Cessation
- 1967-11-08 CH CH1560067A patent/CH512500A/en not_active IP Right Cessation
- 1967-11-10 DE DE19671795724 patent/DE1795724C3/en not_active Expired
- 1967-11-10 DE DE19671695212 patent/DE1695212B2/en active Granted
- 1967-11-20 GR GR670138359A patent/GR38359B/en unknown
- 1967-11-20 CA CA005,531A patent/CA946397A/en not_active Expired
- 1967-11-20 IL IL2897267A patent/IL28972A/en unknown
- 1967-11-21 NL NL6715787A patent/NL6715787A/xx unknown
- 1967-11-22 BE BE706861A patent/BE706861A/en unknown
- 1967-11-22 SE SE43872A patent/SE366988B/xx unknown
- 1967-11-22 AT AT1053467A patent/AT281851B/en not_active IP Right Cessation
- 1967-11-22 GB GB5320167A patent/GB1142448A/en not_active Expired
- 1967-11-22 AT AT01136/69A patent/AT281852B/de not_active IP Right Cessation
- 1967-11-22 SE SE1781070A patent/SE366985B/xx unknown
- 1967-11-22 SE SE1607067A patent/SE349036B/xx unknown
- 1967-11-24 FR FR129677A patent/FR1545331A/en not_active Expired
- 1967-11-24 ES ES347576A patent/ES347576A1/en not_active Expired
- 1967-11-24 NO NO17069767A patent/NO123528B/no unknown
-
1972
- 1972-01-03 PH PH13146A patent/PH11778A/en unknown
-
1974
- 1974-07-15 NL NL7409550A patent/NL7409550A/xx unknown
-
1976
- 1976-01-19 PH PH17992A patent/PH12441A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1695212C3 (en) | 1974-09-19 |
| DE1695212B2 (en) | 1974-02-14 |
| CH521358A (en) | 1972-04-15 |
| GR38359B (en) | 1969-10-30 |
| CA946397A (en) | 1974-04-30 |
| IL28972A (en) | 1973-03-30 |
| AT281851B (en) | 1970-06-10 |
| SE366988B (en) | 1974-05-13 |
| AT281852B (en) | 1970-06-10 |
| NL7409550A (en) | 1974-09-25 |
| DE1795724B2 (en) | 1978-09-28 |
| NL6715787A (en) | 1968-05-27 |
| CH520694A (en) | 1972-03-31 |
| BE706861A (en) | 1968-05-22 |
| DE1795724C3 (en) | 1979-05-23 |
| CH512500A (en) | 1971-09-15 |
| DE1695212A1 (en) | 1971-03-18 |
| GB1142448A (en) | 1969-02-05 |
| SE349036B (en) | 1972-09-18 |
| FR1545331A (en) | 1968-11-08 |
| DE1795724A1 (en) | 1974-02-28 |
| PH11778A (en) | 1978-07-05 |
| PH12441A (en) | 1979-03-01 |
| SE366985B (en) | 1974-05-13 |
| NO123528B (en) | 1971-12-06 |
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