GB1192038A - Improvements in or relating to Propanol Derivatives and the Manufacture Thereof - Google Patents

Improvements in or relating to Propanol Derivatives and the Manufacture Thereof

Info

Publication number
GB1192038A
GB1192038A GB4834267A GB4834267A GB1192038A GB 1192038 A GB1192038 A GB 1192038A GB 4834267 A GB4834267 A GB 4834267A GB 4834267 A GB4834267 A GB 4834267A GB 1192038 A GB1192038 A GB 1192038A
Authority
GB
United Kingdom
Prior art keywords
diphenyl
methyl
general formula
alkylideneamino
propanol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4834267A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1192038A publication Critical patent/GB1192038A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,192,038. 1,1 - Diphenyl - 2 - methyl - 3 - alkylideneamino - propanols. UPJOHN CO. 24 Oct., 1967 [23 Nov., 1966], No. 48342/67. Heading C2C. Novel 1,1- diphenyl - 2 - methyl - 3 - alkylideneamino-propanols of the general formula wherein X, X<SP>1</SP>, X<SP>11</SP>, Y, Y<SP>1</SP> and Y<SP>11</SP> are each a hydrogen atom, a C 1-4 alkyl or alkoxy group or a halogen atom; R is a hydrogen atom or a C 1-5 alkyl group; and R<SP>1</SP> is a C 1-5 alkyl group, are prepared by reaction of a 1,1-diphenyl-2-methyl- 3-amino-propanol of the general formula with an aldehyde or ketone of the general formula RCOR<SP>1</SP> in the presence of a water-immiscible, inert solvent at the boiling-point of the reaction mixture and removal azeotropically of the water formed during the reaction. Pharmaceutical compositions having central nervous system stimulatory and anorexigenic effects comprise as active ingredient a 1,1-diphenyl-2-methyl-3-alkylideneamino-propanol of the first general formula above together with a pharmaceutically acceptable carrier.
GB4834267A 1966-11-23 1967-10-24 Improvements in or relating to Propanol Derivatives and the Manufacture Thereof Expired GB1192038A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59641966A 1966-11-23 1966-11-23

Publications (1)

Publication Number Publication Date
GB1192038A true GB1192038A (en) 1970-05-13

Family

ID=24387208

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4834267A Expired GB1192038A (en) 1966-11-23 1967-10-24 Improvements in or relating to Propanol Derivatives and the Manufacture Thereof

Country Status (6)

Country Link
BE (1) BE706970A (en)
DK (1) DK114550B (en)
ES (1) ES346555A1 (en)
GB (1) GB1192038A (en)
GR (1) GR36397B (en)
NL (1) NL6715761A (en)

Also Published As

Publication number Publication date
DK114550B (en) 1969-07-14
ES346555A1 (en) 1968-12-16
GR36397B (en) 1969-02-05
BE706970A (en) 1968-05-24
NL6715761A (en) 1968-05-24

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees