GR36397B - METHOD FOR THE PREPARATION OF NEW COMPOUNDS. - Google Patents
METHOD FOR THE PREPARATION OF NEW COMPOUNDS.Info
- Publication number
- GR36397B GR36397B GR670136397A GR670136397A GR36397B GR 36397 B GR36397 B GR 36397B GR 670136397 A GR670136397 A GR 670136397A GR 670136397 A GR670136397 A GR 670136397A GR 36397 B GR36397 B GR 36397B
- Authority
- GR
- Greece
- Prior art keywords
- formula
- carbon atoms
- preparation
- compound
- alkyl containing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- XGYCHIPEPHYUIH-UHFFFAOYSA-N 2-mdp Chemical compound C=1C=CC=CC=1C(O)(C(CN)C)C1=CC=CC=C1 XGYCHIPEPHYUIH-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
ία μέθοδος παρασκευής ενώσεως του τύπου (τύπος) εις τον οποίο τα Χ, Χ1, Χ2,Υ,Υ1 και Υ2 είναι υδρογόνον, αλκύλιον περιέχον από 1 έως και 4 άτομα άνθρακος, αλκοξύ περιέχον από 1 έως 4 άτομα άνθρακος, 'η αλογόνον το R είναι υδρογόνο ή αλκύλιο περιέχοναπό 1 έως 5 άτομα άνθρακος και το R1είναι αλκύλιο περιέχον από 1 έως και 5 άτομα άνθρακος, περιλαμβάνουσα την αντίδρασιν μιάς 1,1-διφαινυλο-2-μέθυλ-3-αμινοπροπανόλης του τύπου (τύπος) με μία ένωση του τύπου (τύπος), εις τους οποίους το Χ, Χ1, Χ2, Υ,Υ1,Υ2, R και R1 είναι ως ανωτέρω δίδονται επί παρουσία μη αναμίξιμου μεθ' ύδατος αδρανούς διαλυτικού εις την θερμοκρασία του σημείου ζέσεως του μίγματοςτης αντιδράσεως, την αφαίρεση κατά την διάρκειαν της αντιδράσεως του ύδατος αζεοτροπικώς και τηναπομόνωσιν της ενώσεως του τύπου 1 με αφαίρεση του διαλυτικού και ανακρυστάλλωσιν.A process for the preparation of a compound of formula (formula) in which X, X1, X2, Y, Y1 and Y2 are hydrogen, alkyl containing from 1 to 4 carbon atoms, alkoxy containing from 1 to 4 carbon atoms, or halogen R is hydrogen or alkyl containing from 1 to 5 carbon atoms and R1 is alkyl containing from 1 to 5 carbon atoms, comprising reacting a 1,1-diphenyl-2-methyl-3-aminopropanol of formula (formula) with a compound of formula (formula), in which X, X1, X2, Y, Y1, Y2, R and R1 are as above are given in the presence of an immiscible water-inert solvent at the boiling point temperature of the reaction mixture, the duration of the reaction of the water azeotropically and the isolation of the compound of formula 1 by removal of the solvent and recrystallization.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59641966A | 1966-11-23 | 1966-11-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR36397B true GR36397B (en) | 1969-02-05 |
Family
ID=24387208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR670136397A GR36397B (en) | 1966-11-23 | 1967-10-11 | METHOD FOR THE PREPARATION OF NEW COMPOUNDS. |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE706970A (en) |
| DK (1) | DK114550B (en) |
| ES (1) | ES346555A1 (en) |
| GB (1) | GB1192038A (en) |
| GR (1) | GR36397B (en) |
| NL (1) | NL6715761A (en) |
-
1967
- 1967-10-11 GR GR670136397A patent/GR36397B/en unknown
- 1967-10-24 GB GB4834267A patent/GB1192038A/en not_active Expired
- 1967-10-28 ES ES346555A patent/ES346555A1/en not_active Expired
- 1967-11-10 DK DK562867A patent/DK114550B/en unknown
- 1967-11-21 NL NL6715761A patent/NL6715761A/xx unknown
- 1967-11-23 BE BE706970D patent/BE706970A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES346555A1 (en) | 1968-12-16 |
| NL6715761A (en) | 1968-05-24 |
| DK114550B (en) | 1969-07-14 |
| BE706970A (en) | 1968-05-24 |
| GB1192038A (en) | 1970-05-13 |
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