SU473359A3 - Method for preparing benzenesulfonylurea - Google Patents

Description

where R, R, R, and X have the instructions of the pump, the product is washed and the role of Ki and in 1 are divided by the known methods 1, cprs 1. goes to sod when processing with alkaline ai-cinaM i.

11 p and me r 1. - 14 - p - {2 - Methoxy-5xdorbeisamido) -ethyl-6eii3o / C lymphoiml N- (2.5-endoltsteidetsik.togeksid) -soch1 and: I.

To the rattor of g K - (4 - p - (2 - (n () cci -5 hdorbenzamido) - ethid - benzenesulfoid; N - (2,5 - eidomethyl cycc. Cyx;) - TIIO.MOchevppa and 50 ml of methanol up to 0 d1 d | g ) 7 0.5 g of mercuric oxide and one-year potassium carbonate, heated by reconciliation of 4 chagons to 50- -60 ° (filter, thicken, cristad from dilute methano1a and H0, v-teaT and rostop N-4 methyl ester p- (2motoxy - 5 - hdorbenzamrgdo) - these, - beisolsulfonide -M- (2.5 - endometnins to / yuhexyl) - isometocins, t, pl. 18-120С.

0.1 g of non-pure ester, 2 zl of dnoxia and 10 ml of concentrated sol.pay / yuty heat 20 min in a naro; yu bath, remove it into water, draw off a precipitate. NSD: rista; 1L11zovyvayu it from pasbap.cheynogo metaiol n target sochu-mt ui 186--188 C.

Target and product specimen ts takh ;;. pe; nagrepanni obtained simple metch; 10 -; (efnra for 1 hour with 2 and. caustic soda in a steam bath.

P p and mor 2. N - 4 - p - (2 - Methoxy-5xd () rbe gzamido) - etid - benzoleul11 (|) it1 :; W - (2,5 - endoUdideyiikdogeksi.t) -urea.

To 0.8 g of endomethylaminyl xyxiscnapa.bio The subject of the invention Method and methods for benzodsulfonnolmoche: yu ACID:, t. N: g. ; 11-lj C (Coll. Meta:. (),) 1 30 ml of benzene and iriba 1 from 0.4 g of trimethylade: nna 1.6 g 4 - (-) - (2-methokei-5-hdorbenzamilo) - tnl - ba : tsol; ypoh: yurpd, a, kin t m 2.5 h) cold: 1H: 1H; ohm. thicken and zakuume, with a residue with zod., pound, and stand, department kgg

crystals, they are washed with water, perekristad, 1nzvavyv1Of from smesi methanol-dioxane and but; | participating () t - 4 f) - (2 - mstoksi - 5 - hdorbeiza.mido) - benzenesulfonide -3- (2, 5-endoms.; E cycdohexy.d) - narabanovy kidotu, t.nd. 227-229 ° C.

The resulting acid is also dissolved in nebol:, HIOM, the amount of donoxan and 2 n. caustic iiaipa, heating 45.g ;; on the steam bath, ohda; scattering; breakdown); 1: from oluya, ng; dk 1C-1; 188 C.

PRI me R Ya. L - I 4 - p - (2 - Methoxy5-х .10ртиобензам1 до) - ethyl - benzenshmyLoHH; I - N - (2,5 - enl.metnleichiklokloge)) urea; -g: ha

3 JX - 4-Ж - (2 - Methoxy - 5 - chlorothiobenzam .cho) - Itil 1 - Beiso, -: Sulfonne.1} - (2,5-Ь | Н.10methyrlenny; 101eksi; 1) - Urea s 100 Mi; Ietano; 1a, they are beaten up and:; b1 CHK () m metn, chyndnda, yunip t 2 hours with reverse chilli chick, rastorptel ;; METT1 LYOLI .g. from 1H) and vacuum in vacuum, disperse the residue into the sky of the dnoxia a, onIpisaic-T for 1 hour, 2 hours. feeders: yes and no; 5; bath; o.ch.chayut, diluted with water, with acetic acid, precipitated with 1% ammonia solution, cerium: pHA; 1L1-; Zoneh1; ayut from metha ol and added 1: barely 1) oi iukt. t. id 186--188 ° C.

guilt about used to her form cho

-SP - Nil-IM., LlPi

where R is lower alkyl, and is naturally methyl, id 1 and 13 is adceide;

X is hydrogen, fluorine, xdor, and .chio bromine, nreimugn, naturally xdor, alkali alkyd, and highly specific lower adkoxy.ch, nreimun1est; Jenzo Lstoksnd. in position 4 or 5 but not denoted for carbamide gruzza;

Penny sulphonylisourea complex, niprate benzyl sulfate phenyl benzene sulfonyl otiine, ocher sulfonylnarabioic acid, a - TIPY benzosulfonidalo; . of carbonic acid, a compound of the total

56

(,,. so, -NH-r, n-.m-Rj / I-v

03 Ri

where R, Ri and X as above, derivatives with parabanic acid or

R2 is an O- or S-isocomolecular alkyl compound of the general formula

or halogen, mainly chlorine, or their °

where R, RI, Ra, and X have the abovementioned values, benzenesulfonylisotiose, ether, o: soaps and reaction products of urea, benzenesulfonylparabanoic acid are used by known methods, or amides are converted to benzenesulfonyl halide by treatment with alkaline agents of formic acid.

Priority featured:

11/29/66 - subject to saponification idle time 13.07.67 - wash the saponified ester with benzene sulfonyl isomers - ° of the general formula

Vc N-CH2-CH, -H (S (i, -Mi-r, (i-NH-R, V. / ..-.,

where R, RI, R2, and X are as indicated above, or 35 compounds of the general formula that are hydroxy-parabolic or

H, -CH. - (- SO, -NH-C-ls -R,

 VTT;, I

OR R, RS where R, RI, R2 and X are as defined above.

SO ,, - NH-C N-R,