GB1212695A - Benzenesulphonyl-ureas and process for preparing them - Google Patents
Benzenesulphonyl-ureas and process for preparing themInfo
- Publication number
- GB1212695A GB1212695A GB57617/67A GB5761767A GB1212695A GB 1212695 A GB1212695 A GB 1212695A GB 57617/67 A GB57617/67 A GB 57617/67A GB 5761767 A GB5761767 A GB 5761767A GB 1212695 A GB1212695 A GB 1212695A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- ethyl
- alkyl
- methyl
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,212,695. Sulphonyl - ureas. FARBWERKE HOECHST A.G. 19 Dec., 1967 [19 Dec., 1966], No. 57617/67. Heading C2C. Novel compounds I (including salts thereof) in which R signifies a C 1-4 alkyl or C 2-4 alkenyl group, X which is in the 4- or 5-position with respect to the carbonamide group signifies acyl (contains up to 4 carbons), -NO 2 , -CF 3 , -CN, -SMe, phenyl or benzyl, Y signifies -CH 2 ÀCH 2 -, -CH(CH 3 )ÀCH 2 - or -CH 2 ÀCH- (CH 3 )- and R<SP>1</SP> signifies (a) a C 3-6 alkyl or C 3-6 alkenyl group, (b) a phenyl-C 1-4 -alkyl group, (c) a cyclohexyl - C 1-4 - alkyl, cycloheptyl - methyl (or -ethyl) or cyclooctyl - methyl group, (d) an endoalkylene - cyclohexyl, - cyclohexenyl, - cyclohexylmethyl - cyclohexenylmethyl group containing 1 or 2 endoalkylene carbon atoms, (e) a C 1-4 - alkyl - cyclohexyl or C 1-4 - alkoxy - cyclohexyl group, (f) a C 5-8 cycloalkyl group, or (g) a cyclohexenyl or cyclohexenyl - methyl group, are prepared utilizing standard methods. 4 - (# - <2 - Ethoxy - 5 - acetylbenzamido> - ethyl) - benzenesulphonamide is obtained by the interaction of 2 - ethoxy - 5 - acetyl - benzoic acid and 4 - (# - aminoethyl) - benzenesulphonamide. N - [4(# - <2 - Methoxy - 5 - acetylbenzamide> - ethyl) - benzenesulphonyl] - methyl - urethane is obtained by the interaction of chloroformic acid methyl ester and the corresponding benzenesulphonamide. N - [4 - (# - <2 - Methoxy - 5 - acetyl - benzamido> - ethyl) - benzenesulphonyl] - N<SP>1</SP> - (#- phenyl - ethyl) - thiourea, obtained by reacting phenylethyl isocyanate with the corresponding sulphonamide, is converted to N - [4 - (# - <2- methoxy - 5 - acetylbenzamido> - ethyl) - benzenesulphonyl] - N<SP>1</SP> - (# - phenylethyl) - isourea - methyl ether by treatment with mercury oxide in the presence of methanol and dimethylformamide. Pharmaceutical preparations having a hypoglycemic action contain as active ingredient compounds I; administration is suitably in the form of a tablet or powder for oral use.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF0051007 | 1966-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1212695A true GB1212695A (en) | 1970-11-18 |
Family
ID=7104260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB57617/67A Expired GB1212695A (en) | 1966-12-19 | 1967-12-19 | Benzenesulphonyl-ureas and process for preparing them |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5132622B1 (en) |
| AT (7) | AT276433B (en) |
| BE (1) | BE708212A (en) |
| CH (1) | CH509279A (en) |
| CU (1) | CU33297A (en) |
| CY (1) | CY618A (en) |
| DE (1) | DE1568648C3 (en) |
| DK (1) | DK126110B (en) |
| ES (1) | ES348374A1 (en) |
| FI (1) | FI45964C (en) |
| FR (2) | FR1571321A (en) |
| GB (1) | GB1212695A (en) |
| IL (1) | IL29019A (en) |
| LU (1) | LU55101A1 (en) |
| MC (1) | MC697A1 (en) |
| MY (1) | MY7200014A (en) |
| NL (1) | NL6716110A (en) |
| NO (1) | NO122416B (en) |
| OA (1) | OA03382A (en) |
| PL (1) | PL69678B1 (en) |
| SE (1) | SE344061B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5574069A (en) * | 1993-02-23 | 1996-11-12 | Hoechst Aktiengesellschaft | Substituted benzenesulfonylureas and -thioureas- process for their preparation and their use as pharmaceuticals |
| US5607976A (en) * | 1995-02-10 | 1997-03-04 | Hoechst Aktiengesellschaft | Substituted benzenesulfonyl-thioureas and pharmaceutical preparations containing them |
| CN105579433A (en) * | 2013-05-21 | 2016-05-11 | 弗吉尼亚联邦大学 | Cryopyrin inhibitors for preventing and treating inflammation |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791638A (en) * | 1971-11-20 | 1973-05-21 | Hoechst Ag | SULFONYL-UREES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
-
1966
- 1966-12-19 DE DE1568648A patent/DE1568648C3/en not_active Expired
-
1967
- 1967-11-27 NL NL6716110A patent/NL6716110A/xx unknown
- 1967-11-27 IL IL29019A patent/IL29019A/en unknown
- 1967-12-01 FI FI673237A patent/FI45964C/en active
- 1967-12-11 MC MC735A patent/MC697A1/en unknown
- 1967-12-13 DK DK624367AA patent/DK126110B/en unknown
- 1967-12-14 LU LU55101D patent/LU55101A1/xx unknown
- 1967-12-14 OA OA53122A patent/OA03382A/en unknown
- 1967-12-15 CH CH1762067A patent/CH509279A/en not_active IP Right Cessation
- 1967-12-16 ES ES348374A patent/ES348374A1/en not_active Expired
- 1967-12-18 AT AT1153568A patent/AT276433B/en active
- 1967-12-18 AT AT1153768A patent/AT276435B/en active
- 1967-12-18 AT AT1153468A patent/AT289135B/en not_active IP Right Cessation
- 1967-12-18 AT AT1138667A patent/AT276425B/en active
- 1967-12-18 AT AT1153668A patent/AT276434B/en active
- 1967-12-18 AT AT1153268A patent/AT291275B/en not_active IP Right Cessation
- 1967-12-18 AT AT1153368A patent/AT276432B/en active
- 1967-12-18 FR FR1571321D patent/FR1571321A/fr not_active Expired
- 1967-12-18 PL PL1967124183A patent/PL69678B1/pl unknown
- 1967-12-18 NO NO171025A patent/NO122416B/no unknown
- 1967-12-19 GB GB57617/67A patent/GB1212695A/en not_active Expired
- 1967-12-19 BE BE708212D patent/BE708212A/xx unknown
- 1967-12-19 CU CU33297A patent/CU33297A/en unknown
- 1967-12-19 SE SE17388/67A patent/SE344061B/xx unknown
- 1967-12-19 JP JP42081493A patent/JPS5132622B1/ja active Pending
-
1968
- 1968-03-15 FR FR143954A patent/FR7803M/fr not_active Expired
-
1971
- 1971-10-25 CY CY61871A patent/CY618A/en unknown
-
1972
- 1972-12-30 MY MY14/72A patent/MY7200014A/en unknown
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5574069A (en) * | 1993-02-23 | 1996-11-12 | Hoechst Aktiengesellschaft | Substituted benzenesulfonylureas and -thioureas- process for their preparation and their use as pharmaceuticals |
| US5776980A (en) * | 1993-02-23 | 1998-07-07 | Hoechst Aktiengesellschaft | Substituted benzenesulfonylureas and -thioureas-process for their preparation and their use as pharmaceuticals |
| US6090981A (en) * | 1993-02-23 | 2000-07-18 | Hoechst Aktiengesellschaft | Substituted benzenesulfonylureas and -thioureas--process for their preparation and their use as pharmaceuticals |
| US6335467B1 (en) | 1993-02-23 | 2002-01-01 | Hoechst Aktiengesellschaft | Substituted benzenesulfonylureas and thioureas-process for their preparation and their use as pharmaceuticals |
| US6506937B2 (en) | 1993-02-23 | 2003-01-14 | Heinrich Englert | Substituted benzenesulfonylureas and -thioureas-processes for their preparation and their use as pharmaceuticals |
| US5607976A (en) * | 1995-02-10 | 1997-03-04 | Hoechst Aktiengesellschaft | Substituted benzenesulfonyl-thioureas and pharmaceutical preparations containing them |
| CN105579433A (en) * | 2013-05-21 | 2016-05-11 | 弗吉尼亚联邦大学 | Cryopyrin inhibitors for preventing and treating inflammation |
| US10343985B2 (en) | 2013-05-21 | 2019-07-09 | Virginia Commonwealth University | Cryopyrin inhibitors for preventing and treating inflammation |
Also Published As
| Publication number | Publication date |
|---|---|
| AT289135B (en) | 1971-04-13 |
| AT276434B (en) | 1969-11-25 |
| ES348374A1 (en) | 1969-06-16 |
| FR7803M (en) | 1970-05-11 |
| NO122416B (en) | 1971-06-28 |
| CY618A (en) | 1971-10-25 |
| BE708212A (en) | 1968-06-19 |
| PL69678B1 (en) | 1973-08-31 |
| AT276433B (en) | 1969-11-25 |
| MY7200014A (en) | 1972-12-31 |
| LU55101A1 (en) | 1969-08-08 |
| DE1568648C3 (en) | 1975-03-27 |
| DE1568648A1 (en) | 1970-03-26 |
| AT276425B (en) | 1969-11-25 |
| CH509279A (en) | 1971-06-30 |
| CU33297A (en) | 1968-11-11 |
| FR1571321A (en) | 1969-06-20 |
| AT276435B (en) | 1969-11-25 |
| MC697A1 (en) | 1968-10-21 |
| IL29019A (en) | 1973-05-31 |
| AT291275B (en) | 1971-07-12 |
| OA03382A (en) | 1970-12-15 |
| SU366606A3 (en) | 1973-01-16 |
| NL6716110A (en) | 1968-06-20 |
| FI45964C (en) | 1972-11-10 |
| FI45964B (en) | 1972-07-31 |
| DK126110B (en) | 1973-06-12 |
| AT276432B (en) | 1969-11-25 |
| DE1568648B2 (en) | 1974-08-15 |
| SE344061B (en) | 1972-03-27 |
| JPS5132622B1 (en) | 1976-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |