ES338638A1 - Procedimiento para la preparacion de nuevos esteres de aci-do fenilacetico sus tituidos. - Google Patents
Procedimiento para la preparacion de nuevos esteres de aci-do fenilacetico sus tituidos.Info
- Publication number
- ES338638A1 ES338638A1 ES338638A ES338638A ES338638A1 ES 338638 A1 ES338638 A1 ES 338638A1 ES 338638 A ES338638 A ES 338638A ES 338638 A ES338638 A ES 338638A ES 338638 A1 ES338638 A1 ES 338638A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- phenyl
- substituted
- acid
- toluidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- OWPNVXATCSXTBK-UHFFFAOYSA-N 1-phenyl-3h-indol-2-one Chemical class O=C1CC2=CC=CC=C2N1C1=CC=CC=C1 OWPNVXATCSXTBK-UHFFFAOYSA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- -1 aralkyl halide Chemical class 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- VJRUAMORHFCIIM-UHFFFAOYSA-N 3-benzylidene-1-phenylindol-2-one Chemical compound O=C1N(C=2C=CC=CC=2)C2=CC=CC=C2C1=CC1=CC=CC=C1 VJRUAMORHFCIIM-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical class C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000007858 starting material Substances 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- SLPAPGNFCSVQKP-UHFFFAOYSA-N 2,6-dichloro-3-methyl-n-phenylaniline Chemical compound CC1=CC=C(Cl)C(NC=2C=CC=CC=2)=C1Cl SLPAPGNFCSVQKP-UHFFFAOYSA-N 0.000 abstract 1
- HDUUZPLYVVQTKN-UHFFFAOYSA-N 2,6-dichloro-n-phenylaniline Chemical compound ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 HDUUZPLYVVQTKN-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 229960001413 acetanilide Drugs 0.000 abstract 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 abstract 1
- 239000012346 acetyl chloride Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- ZWJINEZUASEZBH-UHFFFAOYSA-N fenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC=C1 ZWJINEZUASEZBH-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- FZERHIULMFGESH-UHFFFAOYSA-N methylenecarboxanilide Natural products CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- MNWBNISUBARLIT-UHFFFAOYSA-N sodium cyanide Chemical compound [Na+].N#[C-] MNWBNISUBARLIT-UHFFFAOYSA-N 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH462666A CH473769A (de) | 1966-03-30 | 1966-03-30 | Verfahren zur Herstellung von neuen substituierten Phenylessigsäureestern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES338638A1 true ES338638A1 (es) | 1968-07-01 |
Family
ID=4279632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES338638A Expired ES338638A1 (es) | 1966-03-30 | 1967-03-29 | Procedimiento para la preparacion de nuevos esteres de aci-do fenilacetico sus tituidos. |
Country Status (15)
| Country | Link |
|---|---|
| AT (1) | AT271455B (en, 2012) |
| BE (1) | BE696248A (en, 2012) |
| CH (1) | CH473769A (en, 2012) |
| DE (1) | DE1618465C3 (en, 2012) |
| DK (1) | DK137325B (en, 2012) |
| ES (1) | ES338638A1 (en, 2012) |
| FI (1) | FI46501C (en, 2012) |
| FR (2) | FR1517251A (en, 2012) |
| GB (1) | GB1132318A (en, 2012) |
| GR (1) | GR36365B (en, 2012) |
| IL (1) | IL27708A (en, 2012) |
| NL (2) | NL6704484A (en, 2012) |
| NO (1) | NO118798B (en, 2012) |
| SE (1) | SE346307B (en, 2012) |
| YU (1) | YU32041B (en, 2012) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2068397A2 (en) * | 1969-10-06 | 1971-08-27 | Geigy Ag J R | Methyl 2-(6-chloro-o-toluidino) phenylacetate antirheumatic |
| JPS549240A (en) * | 1977-06-23 | 1979-01-24 | Asahi Chem Ind Co Ltd | New derivative of phenylglycolic acid, its preparation and analgesic and antiinflammatory agent contining it as effective component |
| IT1097265B (it) * | 1978-06-23 | 1985-08-31 | Acraf | Nouva sintesi di un acido fenilacetico |
| ES8404783A1 (es) * | 1983-03-21 | 1984-05-16 | Prodes Sa | Procedimiento para la obtencion del ester del acido 2-(2,6-diclorofenil)amino bencenoacetico con acido glicolico. |
| JPS6028957A (ja) * | 1983-07-27 | 1985-02-14 | Kaken Pharmaceut Co Ltd | インドリル酢酸およびフエニル酢酸のエステル誘導体およびその製造法 |
| EP0380712B1 (de) * | 1989-01-27 | 1995-01-04 | HEUMANN PHARMA GMBH & CO | Verfahren zur Herstellung von 2,6-Dichlordiphenylaminessigsäurederivaten |
| ITMI20012434A1 (it) * | 2001-11-20 | 2003-05-20 | Dompe Spa | Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono |
| WO2009007827A2 (en) * | 2007-07-10 | 2009-01-15 | Chemisches Institut Schaefer Ag | Novel diclofenac esters and uses thereof |
| EP2870130A4 (en) * | 2012-07-03 | 2015-12-02 | Cellix Bio Private Ltd | COMPOSITIONS AND METHODS FOR TREATING MODERATE TO ACUTE PAIN |
-
0
- NL NL137301D patent/NL137301C/xx active
-
1966
- 1966-03-30 CH CH462666A patent/CH473769A/de not_active IP Right Cessation
-
1967
- 1967-03-28 FI FI670878A patent/FI46501C/fi active
- 1967-03-29 BE BE696248D patent/BE696248A/xx not_active IP Right Cessation
- 1967-03-29 AT AT299567A patent/AT271455B/de active
- 1967-03-29 NL NL6704484A patent/NL6704484A/xx unknown
- 1967-03-29 ES ES338638A patent/ES338638A1/es not_active Expired
- 1967-03-29 SE SE4283/67A patent/SE346307B/xx unknown
- 1967-03-29 YU YU0612/67A patent/YU32041B/xx unknown
- 1967-03-29 DK DK164667AA patent/DK137325B/da not_active IP Right Cessation
- 1967-03-29 FR FR100667A patent/FR1517251A/fr not_active Expired
- 1967-03-29 IL IL27708A patent/IL27708A/en unknown
- 1967-03-29 NO NO167485A patent/NO118798B/no unknown
- 1967-03-29 DE DE1618465A patent/DE1618465C3/de not_active Expired
- 1967-03-29 GR GR670136365A patent/GR36365B/el unknown
- 1967-03-29 GB GB14261/67A patent/GB1132318A/en not_active Expired
- 1967-06-27 FR FR112053A patent/FR6680M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI46501C (fi) | 1973-04-10 |
| DE1618465A1 (de) | 1971-05-27 |
| FR1517251A (fr) | 1968-03-15 |
| NL6704484A (en, 2012) | 1967-10-02 |
| GR36365B (el) | 1969-02-04 |
| DK137325B (da) | 1978-02-20 |
| AT271455B (de) | 1969-06-10 |
| CH473769A (de) | 1969-06-15 |
| YU61267A (en) | 1973-08-31 |
| BE696248A (en, 2012) | 1967-09-29 |
| YU32041B (en) | 1974-02-28 |
| DE1618465C3 (de) | 1979-05-31 |
| DE1618465B2 (de) | 1978-09-28 |
| GB1132318A (en) | 1968-10-30 |
| FI46501B (fi) | 1973-01-02 |
| IL27708A (en) | 1971-01-28 |
| FR6680M (en, 2012) | 1969-02-03 |
| SE346307B (en, 2012) | 1972-07-03 |
| NO118798B (en, 2012) | 1970-02-16 |
| NL137301C (en, 2012) | |
| DK137325C (en, 2012) | 1978-07-17 |
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