ES329299A1 - Procedimiento para la obtencion de nuevas 4,5,6,7-tetrahi- dro - tiazolo, 5,4-c piridinas. - Google Patents
Procedimiento para la obtencion de nuevas 4,5,6,7-tetrahi- dro - tiazolo, 5,4-c piridinas.Info
- Publication number
- ES329299A1 ES329299A1 ES329299A ES329299A ES329299A1 ES 329299 A1 ES329299 A1 ES 329299A1 ES 329299 A ES329299 A ES 329299A ES 329299 A ES329299 A ES 329299A ES 329299 A1 ES329299 A1 ES 329299A1
- Authority
- ES
- Spain
- Prior art keywords
- alkenyl
- aryl
- alkyl
- cycloalkyl
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QSLDIPUHQBHQGY-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,3]thiazolo[5,4-c]pyridine Chemical class C1NCCC2=C1SC=N2 QSLDIPUHQBHQGY-UHFFFAOYSA-N 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- -1 halo C 2-6 alkenyl Chemical group 0.000 abstract 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PZRSRAUPUQOYQX-UHFFFAOYSA-N 3-bromopiperidin-4-one Chemical class BrC1CNCCC1=O PZRSRAUPUQOYQX-UHFFFAOYSA-N 0.000 abstract 1
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003556 thioamides Chemical class 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- E—FIXED CONSTRUCTIONS
- E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
- E02F—DREDGING; SOIL-SHIFTING
- E02F9/00—Component parts of dredgers or soil-shifting machines, not restricted to one of the kinds covered by groups E02F3/00 - E02F7/00
- E02F9/20—Drives; Control devices
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Mining & Mineral Resources (AREA)
- Civil Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Structural Engineering (AREA)
- Molecular Biology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET0029055 | 1965-07-23 | ||
| DET0032992 | 1967-01-16 | ||
| DET0032994 | 1967-01-16 | ||
| DET0032993 | 1967-01-16 | ||
| DET0032990 | 1967-01-16 | ||
| DET0032991 | 1967-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES329299A1 true ES329299A1 (es) | 1968-02-16 |
Family
ID=27512321
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES329299A Expired ES329299A1 (es) | 1965-07-23 | 1966-07-20 | Procedimiento para la obtencion de nuevas 4,5,6,7-tetrahi- dro - tiazolo, 5,4-c piridinas. |
| ES349319A Expired ES349319A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349321A Expired ES349321A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349316A Expired ES349316A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349318A Expired ES349318A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349317A Expired ES349317A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349320A Expired ES349320A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349314A Expired ES349314A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349322A Expired ES349322A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES349319A Expired ES349319A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349321A Expired ES349321A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349316A Expired ES349316A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349318A Expired ES349318A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349317A Expired ES349317A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349320A Expired ES349320A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349314A Expired ES349314A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
| ES349322A Expired ES349322A1 (es) | 1965-07-23 | 1968-01-15 | Procedimiento para la preparacion de 4,5,6,7-tetrahidro - tiazolo (5,4-c) piridinas. |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE684415A (enrdf_load_stackoverflow) |
| BR (1) | BR6681517D0 (enrdf_load_stackoverflow) |
| DE (1) | DE1620508A1 (enrdf_load_stackoverflow) |
| ES (9) | ES329299A1 (enrdf_load_stackoverflow) |
| FR (3) | FR6013M (enrdf_load_stackoverflow) |
| GB (1) | GB1140387A (enrdf_load_stackoverflow) |
| NL (2) | NL6610324A (enrdf_load_stackoverflow) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4847264A (en) * | 1982-07-21 | 1989-07-11 | Rorer Pharmaceutical Corporation | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| GB8333514D0 (en) * | 1983-12-16 | 1984-01-25 | Erba Farmitalia | Tetrahydrothiazolo(5 4-c)pyridine derivatives |
| DE3680929D1 (de) | 1985-02-06 | 1991-09-26 | Boehringer Ingelheim Kg | Verwendung des 2-amino-6-allyl-5,6,7,8-tetrahydro-4h-thiazolo(4,5-d)azepins zur herstellung eines zur behandlung der parkinsonschen erkrankung bzw. des parkinsonismus geeigneten arzneimittels. |
| GB2173187B (en) * | 1985-03-23 | 1988-05-18 | Erba Farmitalia | Condensed 2-substituted thiazole derivatives |
| US5060904A (en) * | 1987-05-01 | 1991-10-29 | David Hegarty | Multi-positionable support stand with movable center of gravity and article holding means |
| CA2314408A1 (en) * | 1997-12-11 | 1999-06-17 | Biochem Pharma Inc. | Antiviral compounds |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| ES2346961T3 (es) | 2001-11-22 | 2010-10-22 | Biovitrum Ab | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| AR041952A1 (es) | 2002-11-14 | 2005-06-01 | Novartis Ag | N-sulfonilaminotiazol |
| CL2004000553A1 (es) * | 2003-03-20 | 2005-02-04 | Actelion Pharmaceuticals Ltd | Uso de compuestos derivados de guanidina como antagonistas del receptor de neuropeptido ff; compuestos derivados de guanidina; procedimientos de preparacion; y composicion farmaceutica que los comprende. |
| EP2266992A3 (en) | 2003-11-12 | 2011-05-18 | Daiichi Sankyo Company, Limited | Process for producing thiazole derivative |
| CA2630718A1 (en) | 2005-11-22 | 2007-05-31 | Amgen Inc. | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| EP2379565A1 (en) * | 2008-12-19 | 2011-10-26 | Schering Corporation | Piperidine and piperazine derivatives and methods of use thereof |
| EP2414340A1 (en) * | 2009-04-03 | 2012-02-08 | Dainippon Sumitomo Pharma Co., Ltd. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| US11071721B2 (en) | 2016-12-02 | 2021-07-27 | Genentech, Inc. | Bicyclic amide compounds and methods of use thereof |
| CR20200002A (es) | 2017-07-14 | 2020-02-10 | Hoffmann La Roche | Compuestos de cetonas bicíclicas y métodos de uso de los mismos |
| MX2020003451A (es) * | 2017-10-31 | 2020-08-03 | Hoffmann La Roche | Sulfonas y sulfoxidos biciclicos y metodos de uso de los mismos. |
| CN109134510A (zh) * | 2018-11-13 | 2019-01-04 | 井冈山大学 | 制备2-氨基-5-cbz-4,5,6,7-四氢噻唑并[5，4-c]吡啶的新方法 |
| WO2020146615A1 (en) | 2019-01-11 | 2020-07-16 | Genentech, Inc. | Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof |
-
1965
- 1965-07-23 DE DE19651620508 patent/DE1620508A1/de active Pending
-
1966
- 1966-07-15 GB GB31938/66A patent/GB1140387A/en not_active Expired
- 1966-07-20 BE BE684415D patent/BE684415A/xx unknown
- 1966-07-20 ES ES329299A patent/ES329299A1/es not_active Expired
- 1966-07-22 FR FR70538A patent/FR6013M/fr not_active Expired
- 1966-07-22 BR BR181517/66A patent/BR6681517D0/pt unknown
- 1966-07-22 FR FR70539A patent/FR1498465A/fr not_active Expired
- 1966-07-22 NL NL6610324A patent/NL6610324A/xx unknown
-
1968
- 1968-01-15 ES ES349319A patent/ES349319A1/es not_active Expired
- 1968-01-15 ES ES349321A patent/ES349321A1/es not_active Expired
- 1968-01-15 ES ES349316A patent/ES349316A1/es not_active Expired
- 1968-01-15 ES ES349318A patent/ES349318A1/es not_active Expired
- 1968-01-15 ES ES349317A patent/ES349317A1/es not_active Expired
- 1968-01-15 ES ES349320A patent/ES349320A1/es not_active Expired
- 1968-01-15 NL NL6800589A patent/NL6800589A/xx unknown
- 1968-01-15 ES ES349314A patent/ES349314A1/es not_active Expired
- 1968-01-15 ES ES349322A patent/ES349322A1/es not_active Expired
- 1968-01-16 FR FR136259A patent/FR94123E/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES349318A1 (es) | 1969-04-01 |
| ES349320A1 (es) | 1969-04-01 |
| ES349319A1 (es) | 1969-04-01 |
| NL6610324A (enrdf_load_stackoverflow) | 1967-01-24 |
| ES349314A1 (es) | 1969-04-01 |
| FR94123E (fr) | 1969-07-04 |
| GB1140387A (en) | 1969-01-15 |
| ES349317A1 (es) | 1969-04-01 |
| BE684415A (enrdf_load_stackoverflow) | 1967-01-20 |
| ES349316A1 (es) | 1969-04-01 |
| ES349321A1 (es) | 1969-04-01 |
| ES349322A1 (es) | 1969-04-01 |
| DE1620508A1 (de) | 1969-09-18 |
| NL6800589A (enrdf_load_stackoverflow) | 1968-07-17 |
| FR1498465A (fr) | 1967-10-20 |
| FR6013M (enrdf_load_stackoverflow) | 1968-05-06 |
| BR6681517D0 (pt) | 1973-12-27 |
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