GB1140387A - 4,5,6,7-tetrahydro-thiazolo-[5,4-c]pyridines - Google Patents
4,5,6,7-tetrahydro-thiazolo-[5,4-c]pyridinesInfo
- Publication number
- GB1140387A GB1140387A GB31938/66A GB3193866A GB1140387A GB 1140387 A GB1140387 A GB 1140387A GB 31938/66 A GB31938/66 A GB 31938/66A GB 3193866 A GB3193866 A GB 3193866A GB 1140387 A GB1140387 A GB 1140387A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkenyl
- aryl
- alkyl
- cycloalkyl
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QSLDIPUHQBHQGY-UHFFFAOYSA-N 4,5,6,7-tetrahydro-[1,3]thiazolo[5,4-c]pyridine Chemical class C1NCCC2=C1SC=N2 QSLDIPUHQBHQGY-UHFFFAOYSA-N 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- -1 halo C 2-6 alkenyl Chemical group 0.000 abstract 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PZRSRAUPUQOYQX-UHFFFAOYSA-N 3-bromopiperidin-4-one Chemical class BrC1CNCCC1=O PZRSRAUPUQOYQX-UHFFFAOYSA-N 0.000 abstract 1
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003556 thioamides Chemical class 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- E—FIXED CONSTRUCTIONS
- E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
- E02F—DREDGING; SOIL-SHIFTING
- E02F9/00—Component parts of dredgers or soil-shifting machines, not restricted to one of the kinds covered by groups E02F3/00 - E02F7/00
- E02F9/20—Drives; Control devices
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Mining & Mineral Resources (AREA)
- Civil Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Structural Engineering (AREA)
- Molecular Biology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET0029055 | 1965-07-23 | ||
| DET0032992 | 1967-01-16 | ||
| DET0032994 | 1967-01-16 | ||
| DET0032993 | 1967-01-16 | ||
| DET0032990 | 1967-01-16 | ||
| DET0032991 | 1967-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1140387A true GB1140387A (en) | 1969-01-15 |
Family
ID=27512321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31938/66A Expired GB1140387A (en) | 1965-07-23 | 1966-07-15 | 4,5,6,7-tetrahydro-thiazolo-[5,4-c]pyridines |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE684415A (enrdf_load_stackoverflow) |
| BR (1) | BR6681517D0 (enrdf_load_stackoverflow) |
| DE (1) | DE1620508A1 (enrdf_load_stackoverflow) |
| ES (9) | ES329299A1 (enrdf_load_stackoverflow) |
| FR (3) | FR6013M (enrdf_load_stackoverflow) |
| GB (1) | GB1140387A (enrdf_load_stackoverflow) |
| NL (2) | NL6610324A (enrdf_load_stackoverflow) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2173187A (en) * | 1985-03-23 | 1986-10-08 | Erba Farmitalia | Condensed 2-substituted thiazole derivatives |
| US4624956A (en) * | 1983-12-16 | 1986-11-25 | Farmitalia Carlo Erba | Ulcer and gastric secretion inhibiting 4,5,6,7-tetrahydrothiazole[5,4-c]pyridine derivatives |
| US4847264A (en) * | 1982-07-21 | 1989-07-11 | Rorer Pharmaceutical Corporation | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| WO2004083218A1 (de) * | 2003-03-20 | 2004-09-30 | Actelion Pharmaceuticals Ltd | Guanidinderivate und ihre verwendung als neuropeptid ff rezeptor-antagonisten |
| US7291734B2 (en) | 2002-11-14 | 2007-11-06 | Novartis Ag | N-sulfonylaminothiazole |
| US7547786B2 (en) | 2003-11-12 | 2009-06-16 | Daiichi Sankyo Company, Limited | Process for producing thiazole derivative |
| WO2010071822A1 (en) * | 2008-12-19 | 2010-06-24 | Schering Corporation | Piperidine and piperazine derivatives and methods of use thereof |
| WO2010114971A1 (en) * | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| US8541592B2 (en) | 2005-11-22 | 2013-09-24 | Amgen Inc. | Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3680929D1 (de) | 1985-02-06 | 1991-09-26 | Boehringer Ingelheim Kg | Verwendung des 2-amino-6-allyl-5,6,7,8-tetrahydro-4h-thiazolo(4,5-d)azepins zur herstellung eines zur behandlung der parkinsonschen erkrankung bzw. des parkinsonismus geeigneten arzneimittels. |
| US5060904A (en) * | 1987-05-01 | 1991-10-29 | David Hegarty | Multi-positionable support stand with movable center of gravity and article holding means |
| CA2314408A1 (en) * | 1997-12-11 | 1999-06-17 | Biochem Pharma Inc. | Antiviral compounds |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| ES2346961T3 (es) | 2001-11-22 | 2010-10-22 | Biovitrum Ab | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa de tipo 1. |
| US11071721B2 (en) | 2016-12-02 | 2021-07-27 | Genentech, Inc. | Bicyclic amide compounds and methods of use thereof |
| CR20200002A (es) | 2017-07-14 | 2020-02-10 | Hoffmann La Roche | Compuestos de cetonas bicíclicas y métodos de uso de los mismos |
| MX2020003451A (es) * | 2017-10-31 | 2020-08-03 | Hoffmann La Roche | Sulfonas y sulfoxidos biciclicos y metodos de uso de los mismos. |
| CN109134510A (zh) * | 2018-11-13 | 2019-01-04 | 井冈山大学 | 制备2-氨基-5-cbz-4,5,6,7-四氢噻唑并[5，4-c]吡啶的新方法 |
| WO2020146615A1 (en) | 2019-01-11 | 2020-07-16 | Genentech, Inc. | Bicyclic pyrrolotriazolr ketone compounds and methods of use thereof |
-
1965
- 1965-07-23 DE DE19651620508 patent/DE1620508A1/de active Pending
-
1966
- 1966-07-15 GB GB31938/66A patent/GB1140387A/en not_active Expired
- 1966-07-20 BE BE684415D patent/BE684415A/xx unknown
- 1966-07-20 ES ES329299A patent/ES329299A1/es not_active Expired
- 1966-07-22 FR FR70538A patent/FR6013M/fr not_active Expired
- 1966-07-22 BR BR181517/66A patent/BR6681517D0/pt unknown
- 1966-07-22 FR FR70539A patent/FR1498465A/fr not_active Expired
- 1966-07-22 NL NL6610324A patent/NL6610324A/xx unknown
-
1968
- 1968-01-15 ES ES349319A patent/ES349319A1/es not_active Expired
- 1968-01-15 ES ES349321A patent/ES349321A1/es not_active Expired
- 1968-01-15 ES ES349316A patent/ES349316A1/es not_active Expired
- 1968-01-15 ES ES349318A patent/ES349318A1/es not_active Expired
- 1968-01-15 ES ES349317A patent/ES349317A1/es not_active Expired
- 1968-01-15 ES ES349320A patent/ES349320A1/es not_active Expired
- 1968-01-15 NL NL6800589A patent/NL6800589A/xx unknown
- 1968-01-15 ES ES349314A patent/ES349314A1/es not_active Expired
- 1968-01-15 ES ES349322A patent/ES349322A1/es not_active Expired
- 1968-01-16 FR FR136259A patent/FR94123E/fr not_active Expired
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4847264A (en) * | 1982-07-21 | 1989-07-11 | Rorer Pharmaceutical Corporation | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| US4624956A (en) * | 1983-12-16 | 1986-11-25 | Farmitalia Carlo Erba | Ulcer and gastric secretion inhibiting 4,5,6,7-tetrahydrothiazole[5,4-c]pyridine derivatives |
| GB2173187A (en) * | 1985-03-23 | 1986-10-08 | Erba Farmitalia | Condensed 2-substituted thiazole derivatives |
| US7291734B2 (en) | 2002-11-14 | 2007-11-06 | Novartis Ag | N-sulfonylaminothiazole |
| WO2004083218A1 (de) * | 2003-03-20 | 2004-09-30 | Actelion Pharmaceuticals Ltd | Guanidinderivate und ihre verwendung als neuropeptid ff rezeptor-antagonisten |
| JP2006520330A (ja) * | 2003-03-20 | 2006-09-07 | アクテリオン ファマシューティカルズ リミテッド | グアニジン誘導体および神経ペプチドｆｆ受容体拮抗物質としてのそれらの使用 |
| RU2337911C2 (ru) * | 2003-03-20 | 2008-11-10 | Актелион Фармасьютикалз Лтд. | Производные гуанидина и их применение в качестве антагонистов рецептора нейропептида ff |
| US7727979B2 (en) | 2003-03-20 | 2010-06-01 | Actelion Pharmaceuticals Ltd. | Guanidine derivatives and their use as neuropeptide FF receptor antagonists |
| US7678910B2 (en) | 2003-11-12 | 2010-03-16 | Daiichi Sankyo Company, Limited | Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]Pyridine-2-carboxylic acid |
| US7547786B2 (en) | 2003-11-12 | 2009-06-16 | Daiichi Sankyo Company, Limited | Process for producing thiazole derivative |
| US7880005B2 (en) | 2003-11-12 | 2011-02-01 | Daiichi Sankyo Company, Limited | Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid |
| US8058440B2 (en) | 2003-11-12 | 2011-11-15 | Daiichi Sankyo Company, Limited | Process for producing 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid |
| US8541592B2 (en) | 2005-11-22 | 2013-09-24 | Amgen Inc. | Inhibitors of 11-beta-hydroxysteroid dehydrogenase type 1 |
| WO2010071822A1 (en) * | 2008-12-19 | 2010-06-24 | Schering Corporation | Piperidine and piperazine derivatives and methods of use thereof |
| US20110245267A1 (en) * | 2008-12-19 | 2011-10-06 | Schering Plough Corporation | Piperidine and piperazine derivatives and methods of use thereof |
| WO2010114971A1 (en) * | 2009-04-03 | 2010-10-07 | Sepracor Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ES329299A1 (es) | 1968-02-16 |
| ES349318A1 (es) | 1969-04-01 |
| ES349320A1 (es) | 1969-04-01 |
| ES349319A1 (es) | 1969-04-01 |
| NL6610324A (enrdf_load_stackoverflow) | 1967-01-24 |
| ES349314A1 (es) | 1969-04-01 |
| FR94123E (fr) | 1969-07-04 |
| ES349317A1 (es) | 1969-04-01 |
| BE684415A (enrdf_load_stackoverflow) | 1967-01-20 |
| ES349316A1 (es) | 1969-04-01 |
| ES349321A1 (es) | 1969-04-01 |
| ES349322A1 (es) | 1969-04-01 |
| DE1620508A1 (de) | 1969-09-18 |
| NL6800589A (enrdf_load_stackoverflow) | 1968-07-17 |
| FR1498465A (fr) | 1967-10-20 |
| FR6013M (enrdf_load_stackoverflow) | 1968-05-06 |
| BR6681517D0 (pt) | 1973-12-27 |
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